Basaloid squamous cell carcinoma of the lung: A rare tumour with a rare clinical presentation

Çakır, Ebru; Demırağ, Funda; Ucoluk, Gulnur Onde; Kaya, Sadi; Memış, Leyla

doi:10.1016/j.lungcan.2007.01.021

Cited by 8 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…BSQCC has histological and cytological similarities with SCC and large cell neuroendocrine cancer; however, BSQCC has a unique immunostaining pattern that is essential for its diagnosis [ 10 ]. BSQCC commonly presents at age above 60, in few cases it was reported at young age [ 11 , 12 ]. The tumor has a strong association with tobacco smoking [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Basaloid Squamous Cell Carcinoma of the Lung Associated With Syndrome of Inappropriate Antidiuretic Hormone Secretion

et al. 2017

View full text Add to dashboard Cite

Basaloid squamous cell carcinoma (BSQCC) of the lung is a very rare subtype of squamous cell carcinoma (SCC). There have been no reported cases of syndrome of inappropriate anti-diuretic hormone secretion (SIADH) developing concurrently with this tumor. We herein present a case of a 68-year-old female who was diagnosed with lung mass discovered incidentally on preoperative clearance for surgical fixation of right humeral neck fracture. The patient presented to the hospital with nausea, vomiting, diarrhea and fatigue. Sodium level on admission was 115 mmol/L. Further workup confirmed a diagnosis of BSQCC of the lung and SIADH.

show abstract

Section: Discussionmentioning

confidence: 99%

Basaloid Squamous Cell Carcinoma of the Lung Associated With Syndrome of Inappropriate Antidiuretic Hormone Secretion

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The cancer is known for its characteristic rapid growth rate and clinical progression as well as poor prognosis compared to non-basaloid squamous cell carcinoma ( 2 3 ). Several case studies have reported on the prognosis and clinicopathological findings of basaloid squamous cell carcinoma of the lung ( 4 5 6 ). However, because of its rarity, the radiologic appearance of this cancer remains to be investigated.…”

Section: Introductionmentioning

confidence: 99%

Basaloid Squamous Cell Carcinoma of the Lung: Two Case Reports with CT Imaging Findings

김

윤

이

et al. 2020

J Korean Soc Radiol

View full text Add to dashboard Cite

Basaloid squamous cell carcinoma of the lung is now considered a subtype of squamous cell carcinoma as per the 2015 WHO classification and remains a relatively unknown type of lung cancer due to its rarity. Here we report two cases of basaloid squamous cell carcinoma of the lung and their CT findings to clarify some of the radiologic features of this type of cancer. Two patients aged 85 and 68 years with lung basaloid squamous cell carcinoma visited our institution and underwent surgical resection. On CT, the lesions were 3.1 and 2.8 cm in size, respectively, well-defined, round in shape with lobulated margins and prominent intratumoral necrosis. The latter case was followed after operation for 20 months, and there was no recurrence of the disease on CT. Although very rare, basaloid squamous cell carcinoma should be considered a subtype of lung cancer in tumors sharing these CT findings.

show abstract

“…Basaloid squamous carcinoma (BSCC) is an uncommon variant of squamous cell carcinoma (SCC), that has predilection for the head and neck, though it has been described throughout the body [1][2][3][4][5][6]. The diagnosis of BSCC is currently based on histological criteria, including focal squamous differentiation, a basaloid pattern associated with frank SCC or carcinoma in situ [7].…”

Section: Introductionmentioning

confidence: 99%

Ber-EP4, CK1, CK7 and CK14 are Useful Markers for Basaloid Squamous Carcinoma: A Study of 45 Cases

Winters

Naud

Evans

et al. 2008

Head and Neck Pathol

View full text Add to dashboard Cite

Diagnosis of basaloid squamous carcinoma (BSCC) currently relies mainly on histological criteria, with variable immunohistochemical results reported in small series. We explored the use of a battery of immunohistochemical stains to elucidate this diagnosis on 45 cases of BSCC. To further elucidate the immunohistochemical profile of BSCC, to explore potential genetic pathways of malignant transformation using proliferation markers, and to investigate a possible link with Human Papillomavirus (HPV). Forty-five cases of BSCC and 34 site-matched cases of squamous cell carcinoma (SCC) were obtained from the archives of the pathology department at our institution. Extensive literature review was undertaken utilizing Medline. Ber-EP4 is a useful diagnostic marker for BSCC, positive in 82% (37/45) of the cases and in 68% (23/34) of SCC. An alternative is the combination of cytokeratins CK14 and CK7, known to be negative, and CK1, known to be positive, which achieves an accuracy of 73% (33/45) in BSCC and 88% (30/34) in SCC. The two diagnostic approaches were in agreement in 66% of the cases; both methods were equally accurate in the divergent cases. Increased expression of the proliferation markers supports the concept that BSCC is a rapidly growing tumor. Results of p16 stains support an etiological link between BSCC and HPV; interestingly, HPV was present significantly more in BSCC (71% (32/45)), than in SCC (59% (20/34)) in this study (P=0.02).

show abstract

Basaloid squamous cell carcinoma of the lung: A rare tumour with a rare clinical presentation

Cited by 8 publications

References 14 publications

Basaloid Squamous Cell Carcinoma of the Lung Associated With Syndrome of Inappropriate Antidiuretic Hormone Secretion

Basaloid Squamous Cell Carcinoma of the Lung Associated With Syndrome of Inappropriate Antidiuretic Hormone Secretion

Basaloid Squamous Cell Carcinoma of the Lung: Two Case Reports with CT Imaging Findings

Ber-EP4, CK1, CK7 and CK14 are Useful Markers for Basaloid Squamous Carcinoma: A Study of 45 Cases

Contact Info

Product

Resources

About