1975
DOI: 10.1016/0014-5793(75)80856-8
|View full text |Cite
|
Sign up to set email alerts
|

Base catalyzed aminolysis of carbodithioic esters and its interest in solid phase sequential analysis of peptides

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

0
4
0

Year Published

1977
1977
2010
2010

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 17 publications
(4 citation statements)
references
References 9 publications
0
4
0
Order By: Relevance
“…Their employed procedure requires the polymer to be reacted with a functional azo-initiator after isolation of the polymer. 11 In addition, dithioesters and trithiocarbonates may undergo aminolysis 12,13 and hydrolysis 14 to yield thiol functional polymer. When methacrylates are employed, they can undergo intramolecular cyclization to form thiolactone end-groups.…”
Section: Introductionmentioning
confidence: 99%
“…Their employed procedure requires the polymer to be reacted with a functional azo-initiator after isolation of the polymer. 11 In addition, dithioesters and trithiocarbonates may undergo aminolysis 12,13 and hydrolysis 14 to yield thiol functional polymer. When methacrylates are employed, they can undergo intramolecular cyclization to form thiolactone end-groups.…”
Section: Introductionmentioning
confidence: 99%
“…Our preliminary reports in enzyme modification using dithioesters ( thioacylation ) concerned grafting reactions of either amphililic poly(ethylene oxide) oligomers or hydrophobic alkyl chains or phenyl rings. , This new method for protein chemical modification is based on the known thioacylation of primary and secondary amines by dithioesters and dithio acids which proceeds rapidly at room temperature and was originally applied to esters of amino acids or dipeptides in order to promote a new protecting group . As the back-pathway from thioacylated products to free amino groups could not be easily performed at that time, the use of thioacylating reagents as protecting groups during peptide syntheses or reactions was rapidly eliminated . However, these older works have suggested the use of dithioesters as protein thioacylating agents.…”
Section: Introductionmentioning
confidence: 99%
“…3 As the back-pathway from thioacylated products to free amino groups could not be easily performed at that time, 4 the use of thioacylating reagents as protecting groups during peptide syntheses or reactions was rapidly eliminated. 5 However, these older works have suggested the use of dithioesters as protein thioacylating agents.…”
Section: Introductionmentioning
confidence: 99%
“…The use of phenylisothiocyanate (Edman reagent) as a stepwise-degradation reagent for amino acids from peptides or proteins has been one of the most useful methods of amino acid-sequence determination (Edman, 1950;Edman & Begg, 1967;Laursen, 1971). Although several new reagents (Barrett & Leigh, 1975;Previero et al, 1975) and new techniques (Morris et al, 1971;Bradbury et al, 1974;Priddle et al, 1976) have been developed, none is in widespread use to date.…”
mentioning
confidence: 99%