Base of the skull metastases in metastatic castration-resistant prostate cancer

Mt, Bourlon; Lm, Glode; Crawford, E. David

doi:10.46883/onc.2014.2812.1115

Cited by 6 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chondrosarcomas are destructive masses with irregulary contours, showing heterogeneous contrast enhancement [1,9]. Metastases at the jugular foramen and at other regions of the skull base classically present as lytic lesions [9][10][11][12][13]. In the present case, imaging findings of the mass were not typical of a metastasis.…”

Section: Discussionmentioning

confidence: 66%

Metastasis of lung cancer in jugular foramen: a case report

2019

View full text Add to dashboard Cite

Jugular foramen tumors are uncommon cranial base lesions that cause difficulties not only in diagnosis but in treatment as well. Paraganglioma is the most common tumor involving this region. Other common tumors arising in the jugular foramen are meningiomas, schwannomas and chondrosarcomas. Metastatic involvement of this location is rare. We present a case of metastasis of lung adenocarcinoma in jugular foramen presented with cranial neuropathy. Although it is rare, metastasis of a systemic malignancy should always be considered in the differential diagnosis of a mass involving jugular foramen.

show abstract

Section: Discussionmentioning

confidence: 66%

Metastasis of lung cancer in jugular foramen: a case report

2019

View full text Add to dashboard Cite

show abstract

“…These metastases most often occur secondary to breast, lung, and prostate cancers. In rare cases, skull involvement is the first and only site of distant recurrence [ 4 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Cranial neurological deficits or nerve palsies caused by prostatic cancer metastasis are uncommon in advanced disease but constitute important clinical characteristics. Skull metastasis can cause symptoms of nervous system debilitation, such as cranial nerve palsy, preferentially causing urological symptoms, facial nerve palsy, multiple cranial nerve palsies, otological symptoms, and ophthalmoplegia [ [2] , [3] , [4] , 14 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Prostate cancer metastasis is frequently observed in the axial skeleton, and skull bone metastasis in prostatic adenocarcinoma (PCa) is extremely rare, accounting for less than 2% of all metastases. It often invades the base of the skull and has diverse clinical manifestations to preferentially cause urological symptoms or multiple cranial nerve palsies, otological symptoms, and ophthalmoplegia, especially bone pain or cranial deficits [ [1] , [2] , [3] , [4] , [5] ].…”

Section: Introductionmentioning

confidence: 99%

“…Most skull bone metastases are purely intraosseous lesions limited to the calvarium or base of the skull [ 6 ]. A review of previous reports and literature revealed that metastatic prostate cancer of the temporal bone is rare, especially in the frontotemporal bone [ [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Incidental finding of metastatic prostatic adenocarcinoma of frontotemporal bone presenting as subdual hematoma: A case report and review of literature

Liu¹,

Chang²,

Chang³

2022

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

Introduction and important: Prostatic cancer is often prone to metastasis and bone invasion. Skull metastasis in prostate cancer is uncommon, accounting for less than 2% of all metastases. However, frontotemporal bone metastasis without dural or brain metastasis is rare. Case presentation Herein, we report the case of a 91-year-old male patient who presented with a sudden-onset dizziness, a fall to the ground, and gradual loss of consciousness. Computed tomography (CT) of the brain revealed an aggressive bony lesion secondary to locally advanced metastatic malignancy and subdural hematoma. Subsequently, he underwent decompressive craniectomy. Histopathological and immunohistochemical (IHC) examinations demonstrated metastatic prostatic adenocarcinoma (PCa). Although after treatment by a multidisciplinary team, unfortunately, the patient expired two months after the surgery and could no longer be traced. Clinical discussion In the majority of reported cases, CT scans of the brain are often mistaken for subdural hematoma or meningioma. The present case suggests is a preliminary incidental case of a single frontotemporal bony lesion. This is the first case described in the literature of incidental finding of metastatic PCa presenting with asymptomatic characteristics. Conclusion Awareness of the possibility of metastatic PCa involving the skull bones, as well as histopathological and IHC examinations, are important to arrive at a correct initial diagnosis.

show abstract

Cranial nerve palsy caused by metastasis to the skull base in patients with castration‐resistant prostate cancer: Three case reports

et al. 2021

View full text Add to dashboard Cite

Introduction Skull base metastasis of prostate cancer associated with cranial nerve palsy is rare. We observed three patients with aggressive prostate cancer who experienced cranial nerve palsy. Case presentation Case 1 was a 53‐year‐old patient who was treated with carboplatin and etoposide. He noticed sensory abnormalities on his left mouth edge. Head magnetic resonance imaging revealed skull base metastasis. Case 2 was a 50‐year‐old patient who received docetaxel. This patient exhibited ptosis of the left eye. Skull base metastasis was detected by magnetic resonance imaging. External beam radiation therapy was performed. Case 3 was a 64‐year‐old patient who was treated with docetaxel. He experienced ptosis of the right eye and diplopia. He was also treated with external beam radiation therapy. Conclusion External beam radiation therapy exhibited some efficacy against the symptoms, but skull base metastasis of treatment‐resistant prostate cancer has poor prognosis. Three patients died within 3 months after symptoms occurred with or without external beam radiation therapy.

show abstract

Base of the skull metastases in metastatic castration-resistant prostate cancer

Cited by 6 publications

References 0 publications

Metastasis of lung cancer in jugular foramen: a case report

Metastasis of lung cancer in jugular foramen: a case report

Incidental finding of metastatic prostatic adenocarcinoma of frontotemporal bone presenting as subdual hematoma: A case report and review of literature

Cranial nerve palsy caused by metastasis to the skull base in patients with castration‐resistant prostate cancer: Three case reports

Contact Info

Product

Resources

About