Base-promoted cyclization ofortho-hydroxyacetophenones within situgenerated cyclopropenes: diastereoselective access to spirobenzo[b]oxepines and related precursors

Abstract

An unprecedented [5+2] spirocyclization route to a vital class of functionalized spirobenzo[b]oxepine-cyclopropanes in good to high yields with excellent diastereoselectivities is reported. This domino reaction progresses through a regioselective oxa-Michael...