2019
DOI: 10.1002/cbic.201900253
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Base‐Sequence‐Independent Efficient Redox Switching of Self‐Assembled DNA Nanocages

Abstract: Stimuli responsivity has been extensively pursued in dynamic DNA nanotechnology, due to its incredible application potentials. Among diverse dynamic systems, redox‐responsive DNA assembly holds great promise for broad applications, especially considering that redox processes widely exist in various physiological environments. However, only a few studies have been reported on redox‐sensitive dynamic DNA assembly. Albeit ingenious, most of these studies are either dependent on the DNA sequence or involve chemica… Show more

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Cited by 4 publications
(7 citation statements)
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“…To allow the DNA crystal to respond to the redox potential, we introduced cystamine (Cyst) into the buffer. [31][32][33] In Cyst, two amino groups are joined together by a redox-sensitive disulfide bond. At neutral pH, Cyst exists as Cyst 2+ with both amino groups protonated.…”
Section: Dna Crystals Respond To Redox Reagentsmentioning
confidence: 99%
“…To allow the DNA crystal to respond to the redox potential, we introduced cystamine (Cyst) into the buffer. [31][32][33] In Cyst, two amino groups are joined together by a redox-sensitive disulfide bond. At neutral pH, Cyst exists as Cyst 2+ with both amino groups protonated.…”
Section: Dna Crystals Respond To Redox Reagentsmentioning
confidence: 99%
“…On this basis, DNA nanostructures that could be formed and deformed with kinetic redox control via disulfide bonds were designed . Another switchable DNA self-assembly was created via cystamine and cysteamine interconversion . The assembly and disassembly processes were controlled by the addition of peroxide and GSH, respectively, which could be used as a stimulus-responsive cargo delivery system.…”
Section: Nucleic Acid Carriers With Disulfide-sensitive Functionalitiesmentioning
confidence: 99%
“…209 Another switchable DNA self-assembly was created via cystamine and cysteamine interconversion. 210 The assembly and disassembly processes were controlled by the addition of peroxide and GSH, respectively, which could be used as a stimulus-responsive cargo delivery system. Creation of a disulfide-containing molecular sticker (DSMS) on a DNA nanostructure was reported to aid in cellular uptake.…”
mentioning
confidence: 99%
“…Subsequent disassembly can be achieved via glutathione (GSH)‐mediated reduction of the resulting disulfide bond. Figure adapted from Wang et al (Wang et al, 2019). (d) Azobenzene UV‐triggered trans to trans cis isomerization (left) and a schematic of the light‐droven opening and closing of azobenzene‐incorporated DNA nano‐tweezers (right).…”
Section: Functional Applications Of Dna Nanostructuresmentioning
confidence: 99%
“…Considering the ubiquitous existence of reductive or oxidative environments in physiological contexts, the development of redox-sensitive DNs would provide many therapeutically relevant applications. A recent, generalizable example of such a system was demonstrated by Wang et al (Wang et al, 2019). DNA tetrahedra were electrostatically assembled with the aid of positively charged cystamine, which features a redox-active disulfide bond in the center of its chemical structure.…”
Section: Oxidation Statementioning
confidence: 99%