Based on network pharmacology to explore the effect and mechanism of Yipibushen decoction in improving obese type 2 diabetes mellitus with oligoasthenotspermia

Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer

“…The Traditional Chinese Medicine Systems Pharmacology (TCMSP) is an online platform for web-based herbal pharmacology that encompasses the relationships between drugs, diseases, and targets . Utilizing the TCMSP database, we searched for herbal ingredients and screened for active components of Digitalis, defined by the criteria of an active molecule (DL) ≥ 0.18, indicating better pharmacological activity and oral bioavailability (OB) ≥ 30%. , We also consulted TCMSP for the protein targets of these screened active ingredients and supplemented their chemical composition and targets from the literature in CNKI and PubMed. In the UniProt database (), the protein targets were normalized using the species “Homo sapiens”.…”

“… 19 Utilizing the TCMSP database, we searched for herbal ingredients and screened for active components of Digitalis, defined by the criteria of an active molecule (DL) ≥ 0.18, indicating better pharmacological activity and oral bioavailability (OB) ≥ 30%. 20 , 21 We also consulted TCMSP for the protein targets of these screened active ingredients and supplemented their chemical composition and targets from the literature in CNKI and PubMed. In the UniProt database 22 ( ), the protein targets were normalized using the species “ Homo sapiens ”.…”

Modeling of lipolysis in the human body and the methodology for developing technology of supplements for obesity prevention considering the utilization of food industry by-products

“…Obesity is a risk factor for the development of various diseases such as diabetes, atherosclerosis, hypertension, etc. (1)(2)(3)(4)(5). It is known that as body weight decreases, there are processes in the body that counteract weight loss and promote relapse of the disease.…”