Baseline acetylcholinesterase activity and serotonin plasma levels are not associated with delirium in critically ill patients

Tomasi, Cristiane Damiani; Salluh, Jorge I.; Soares, Márcio; Vuolo, Francieli; Zanatta, Francieli; Constantino, Larissa; Zugno, Alexandra I.; Ritter, Cristiane

doi:10.5935/0103-507x.20150029

Cited by 12 publications

(11 citation statements)

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“…A comprehensive evaluation of the titles and abstracts resulted in the exclusion of 202 studies, leaving 39 articles as potentially relevant. 12 -50 Sixty-nine articles were identified using Google Scholar, none of which were included. No additional article was identified or selected from the reference lists of the retained studies (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Biomarker Predictors of Delirium in Acutely Ill Patients: A Systematic Review

Michels¹,

Michelon²,

Damasio³

et al. 2019

J Geriatr Psychiatry Neurol

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Delirium is a serious and common disorder that affects up to 80% of acutely ill patients, mainly the aged. In recent years, several studies pointed out possible biomarkers that could be used alone or in combination with other resources in the diagnosis and follow-up of critically ill patients who develop delirium. In this context, a systematic review was conducted to determine the predictive value of several biomarkers in acutely (critically and noncritically) ill adult patients with delirium. Studies that used the confusion assessment method (CAM) and CAM-intensive care unit as the diagnostic method were considered. The most recent search was performed in November 2017. There was no language restriction. Initially, 626 articles were screened and 39 were included in the study. A comprehensive evaluation of the abstracts resulted in the exclusion of 202 studies, leaving 39 articles as potentially relevant. Inflammatory markers, S100b and cortisol, could predict delirium occurrence in a specific subgroup population of critically ill patients.

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Section: Resultsmentioning

confidence: 99%

Biomarker Predictors of Delirium in Acutely Ill Patients: A Systematic Review

Michels¹,

Michelon²,

Damasio³

et al. 2019

J Geriatr Psychiatry Neurol

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“…При шизофрении наблюдается нарушение метаболизма триптофана по кинурениновому пути: в плазме крови отмечают уменьшение концентрации кинуренинововй кислоты, а после терапии нормализацию ее уровня [55]. Для оценки вероятности возникновения острой дисфункции головного мозга показан прогностический потенциал концентрации серотонина в плазме или активности ацетилхолинэстеразы при поступлении в отделение интенсивной терапии [56].…”

Section: нарушение функции почек уремияunclassified

The role of human and microbial metabolites of triptophane in severe diseases and critical ill (review)

Getsina

Львовна²,

Chernevskaya

et al. 2020

Journal of Clinical Practice

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The growing interest in metabolite circulating in the blood is associated with the accumulation of factual material on the involvement of low-molecular compounds in the development of a number of serious diseases. This review reveals the effect of a whole class of chemical compounds― tryptophan metabolites― on various pathological processes. The following keywords were used to find papers published in the PubMed database for the last 10 years: names of natural indole compounds, methods for their detection, nosology of diseases and critical ill patients. The data is presented in sections, which provide data on the study of tryptophan metabolites in a variety of groups of diseases, such as cancer, cardiovascular disease, kidney disease, bowel, mental disorders, atherosclerosis, etc. Particular attention is paid to the role of indole compounds that enter the systemic circulation as a result of microbial biotransformation of tryptophan, serotonin and other indole metabolites, which can be attributed to the "common metabolites" of humans and microbiota. The most interesting clinical studies are summarized in summary tables and figures. A number of indole metabolites are considered as potential biomarkers. The authors of the review substantiate the metabolomic approach to the study of a number of oncological, septic, mental and other intractable diseases, which opens up new possibilities of influence on the pathological process by targeted regulation in the metabolome/microbiome system.

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“…7,8 As a result, a number of research studies examining the harmful effects of delirium in ICU patients have been investigated. 7,9,10 During hospitalization, patients with delirium have an increased risk of detrimental outcomes. 10 Such as, falls, accidental extubation, pneumonia, pressure injury and adverse drug responses associated with the treatment of restlessness or insomnia.…”

Section: Introductionmentioning

confidence: 99%

“…7,9,10 During hospitalization, patients with delirium have an increased risk of detrimental outcomes. 10 Such as, falls, accidental extubation, pneumonia, pressure injury and adverse drug responses associated with the treatment of restlessness or insomnia. In general, delirium increases the chance of death, as well as the duration of stay in the hospital, medical expenditures and the risk of cognitive impairment in ICU patients.…”

Section: Introductionmentioning

confidence: 99%

“…In general, delirium increases the chance of death, as well as the duration of stay in the hospital, medical expenditures and the risk of cognitive impairment in ICU patients. 10,11 In addition to the monetary burden, delirium has a long-term impact on patients' health. 6 Delirium not only causes significant psychological harm in patients, but it also increases the prevalence of PTSD, anxiety and depression after they discharged from the hospital.…”

Section: Introductionmentioning

confidence: 99%

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Incidence, prevalence and risk factors of delirium in ICU patients: A systematic review and meta‐analysis

Zhang

Wang

et al. 2022

Nursing in Critical Care

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BackgroundDelirium is one of the most common problems in intensive care units (ICU), and it has a detrimental influence on the patients' health. Estimating the prevalence of delirium in ICU patients and understanding the risk factors for delirium are crucial tasks.ObjectiveTo offer empirical support for early detection of the risk of delirium in ICU patients, we conducted a systematic review and meta‐analysis to analyse the incidence， prevalence and risk factors of delirium in ICU patients.MethodsFrom inception to 19th December 2021, PubMed, Embase, Cochrane Library, Web of Science, China Knowledge Resource Integrated Database (CNKI), Wanfang Database, Chinese Biomedical Database (CBM) and Weipu Database (VIP) were searched for inclusion to the study. The quality of the included studies was assessed by two investigators independently. The outcomes of the meta‐analysis, which was conducted using the Stata 12.0 software, were reported using odds ratios (OR) and 95 percent confidence intervals (CI). Heterogeneity was determined using the I2 statistic.ResultsIn this meta‐analysis, 51 studies with a total of 39 076 patients were evaluated. The incidence and prevalence of delirium in ICU patients were 31 per 1000 and 33%, respectively. A total of 28 risk factors were identified. Of these 28 risk factors, the top five modifiable risk factors were pain (OR = 19.74, 95% CI [8.86–30.61]), use of physical restraints (OR = 15.46, 95% CI [3.68–27.25]), respiratory diseases (OR = 14.3, 95% CaI [8.42–20.19]), sleep deprivation (OR = 9.4, 95% CI [6.8–12.1]) and surgery (OR = 8.98, 95% CI [7–15.27]). Non‐modifiable risk factors included age (OR = 1.06, 95% CI[1.04, 1.07]) and gender (OR = 1.45, 95% CI[1.13, 1.77]). Of these 51 studies included in this analysis, 30 studies were shown with a low risk of bias while 21 studies were shown with a moderate risk of bias. Our results also demonstrated that 21 studies and 30 studies with intermediate methodological quality and low methodological quality respectively.ConclusionDelirium was shown to be prevalent among ICU patients. There are 28 risk factors for delirium that we discovered. These risk factors can assist physicians, nurses and other health care professionals prevent delirium in ICU patients.Relevance to practiceDelirium in ICU patients can potentially be prevented through appropriate prevention strategies by intensive care staff.

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Baseline acetylcholinesterase activity and serotonin plasma levels are not associated with delirium in critically ill patients

Cited by 12 publications

References 40 publications

Biomarker Predictors of Delirium in Acutely Ill Patients: A Systematic Review

Biomarker Predictors of Delirium in Acutely Ill Patients: A Systematic Review

The role of human and microbial metabolites of triptophane in severe diseases and critical ill (review)

Incidence, prevalence and risk factors of delirium in ICU patients: A systematic review and meta‐analysis

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