Baseline antibody titres against Salmonella typhi in apparently asymptomatic HIV positive individuals in a tertiary care hospital

Banu, Asima; Hassan, Mir Mohammed Noorul; Anand, Mridu; Srinivasa, Sathyabheemarao

doi:10.4066/amj.2013.1691

Cited by 1 publication

(1 citation statement)

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“…1 Culture of blood (and less definitively urine and stool) is the gold standard for the diagnosis of enteric fever. 2 In developing countries, sensitivity of blood culture is lower still as the patient visits in the hospital during late in the course of the disease and also take antibiotics as self-medication or upon unauthorized prescription prior to hospital visit. Culture methods are frequently sub-optimal.…”

Section: Introductionmentioning

confidence: 99%

Baseline titre of Widal amongst healthy blood donors at tertiary care hospital

Khorgade

Bhise

2017

Int J Res Med Sci

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Background: Indian subcontinent is a hotspot of Typhoid activity with high prevalence rates. The Widal test is one of the commonly used sero-diagnostic test for typhoid fever in developing countries. Lack of proper knowledge of baseline titre of Widal test can lead to over diagnosis of typhoid fever leading to mismanagement of patients. A single cut off value on average titre among healthy individuals needs to be determined. So, the purpose of the present study was to develop recommendations for the interpretation of Widal test results in the local region. The objectives were to determine the baseline Widal titre of study population and to propose titre-values of significance in the diagnosis of enteric fever.Methods: Sera of 242 apparently healthy blood donors from January 2016 to December 2016 in blood bank and Department of Microbiology, Dr. PDMMC, Amravati, Maharashtra, India were subjected to standard quantitative tube and semi-quantitative slide Widal test to know the titre.Results: Highest titre obtained by tube Widal test for TO was 1:320, for TH- 1:160, for AH- 1:80, and for BH- 1:80. Tube Widal titres of ≤1:160 for TO were seen in 238 (98.34%) and for TH titre of ≤1:80 were seen in 238 (98.34%), TO and TH titres of ≥1:160 were seen in 24 (9.91%) and 4 (1.65%) respectively. TO titre of 1:320 was seen in 4(1.65%) and TH titre of 1:160 was seen in 4 (1.64%). Highest titre obtained by semi-quantitative slide Widal for TO was 1:640, for TH, AH and BH was 1:160.Conclusions: We recommend that TO titre of ≥1:320 and TH titre ≥1:160 as diagnostic of typhoid fever and for AH and BH, titres of ≥1:80 should be considered diagnostic respectively in our region. Because of high expected false positivity rate of slide Widal test.

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Section: Introductionmentioning

confidence: 99%