Baseline Association of Motoric Cognitive Risk Syndrome With Sustained Attention, Memory, and Global Cognition

Maguire, Fiachra; Killane, Isabelle; Creagh, Andrew P.; Donoghue, Orna A.; Kenny, Rose Anne; Reilly, Richard B.

doi:10.1016/j.jamda.2017.07.016

Cited by 42 publications

(49 citation statements)

References 31 publications

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“…The reverse, the prevalence of polypharmacy in MCR, has been reported. Maguire and colleagues reported that 34.6% of MCR participants had polypharmacy; 21.3% of participants without MCR had polypharmacy. The relationship between polypharmacy and other dementia syndromes such as MCI has been reported.…”

Section: Discussionsupporting

confidence: 82%

Motoric Cognitive Risk Syndrome in Polypharmacy

George

2020

J American Geriatrics Society

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OBJECTIVES: Risk factors for motoric cognitive risk syndrome (MCR), a predementia syndrome characterized by slow gait and cognitive complaints, have been identified, but few are reversible. Polypharmacy is a potentially reversible risk factor for cognitive decline, but the relationship between MCR and polypharmacy has not been examined. Our aim was to compare the epidemiology of MCR and polypharmacy. DESIGN: Cross-sectional. SETTING: Community-based Health and Retirement Study cohort. PARTICIPANTS: A total of 1119 adults 65 years and older (mean age = 74.7 AE 7.0 y; 59% female). MEASUREMENTS: Polypharmacy is defined as the use of five or more regularly scheduled medications. MCR is defined as cognitive complaints and slow gait in an individual without dementia. RESULTS: The prevalence of MCR among 417 participants with polypharmacy was 10%; it was 6% among 702 participants without polypharmacy. The odds of meeting MCR criteria in those with polypharmacy was 1.8 (confidence interval = 1.0-3.0; P = .035) compared with those without polypharmacy, even after adjusting for high-risk medication use. CONCLUSION: Our results show the coexistence of MCR and polypharmacy in older adults, suggesting a potentially modifiable risk factor for dementia.

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Section: Discussionsupporting

confidence: 82%

Motoric Cognitive Risk Syndrome in Polypharmacy

George

2020

J American Geriatrics Society

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“…On the other hand, it is interesting that slowing on the control task, which can be characterized as a task of sustained attention, was sensitive to gait and gait-related FA. This suggests that more basic cognitive functions, like attention, may also contribute to loss of mobility and be impacted by frontal white matter loss, as attention relies on overlapping neural resources as executive function, and may underlie and modulate performance on executive tasks (Maguire et al, 2018; O'Halloran et al, 2014; Fortenbaugh et al, 2015; Fortenbaugh et al, 2017). This was further supported by observed relationships between MMSE scores and walking speed, suggesting broader cognitive dysfunction in slow walking.…”

Section: Discussionmentioning

confidence: 99%

Compromised prefrontal structure and function are associated with slower walking in older adults

Poole

Wooten

Iloputaife

et al. 2018

NeuroImage: Clinical

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Our previous work demonstrates that reduced activation of the executive network is associated with slow walking speed in a cohort of older adults from the MOBILIZE Boston Study. However, the influence of underlying white matter integrity on the activation of this network and walking speed is unknown. Thus, we used diffusion-weighted imaging and fMRI during an n-back task to assess associations between executive network structure, function, and walking speed. Whole-brain tract-based spatial statistics (TBSS) were used to identify regions of white matter microstructural integrity that were associated with walking speed. The integrity of these regions was then entered into multiple regression models to predict task performance and executive network activation during the n-back task. Among the significant associations of FA with walking speed, we observed the anterior thalamic radiation and superior longitudinal fasciculus were further associated with both n-back response speed and executive network activation. These findings suggest that subtle damage to frontal white matter may contribute to altered executive network activation and slower walking in older adults.

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“…Few studies have examined the association of ADD and depression with MCR, those that have reported diverging results, as studies have found both significant and not significant associations (Verghese et al 2012(Verghese et al , 2014aCallisaya et al 2016;Doi et al 2015;Allali et al 2015;Beauchet et al 2016a;Maguire et al 2018;Wang et al 2016;Winter et al 2011). These mixed results may be explained by the definition used for ADD and depression which may be based on standardized questionnaires or antidepressant use (Verghese et al 2014b;Callisaya et al 2016;Doi et al 2015;Beauchet et al 2016a).…”

Section: Introductionmentioning

confidence: 99%

The association of anxio-depressive disorders and depression with motoric cognitive risk syndrome: results from the baseline assessment of the Canadian longitudinal study on aging

2019

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Motoric cognitive risk syndrome (MCR), anxio-depressive disorders (ADD), and depression are associated with cognitive complaint and slow gait speed. The study aims to examine (1) the association of ADD and depression with MCR, and (2) the influence of the type and the severity of ADD and age on this association in older adults. A total of 2 9 , 5 6 9 p a r t i c i p a n t s f r e e f r o m c o g n i t i v e impairment with walking speed measure recruited at baseline in the Canadian Longitudinal Study on Aging (CLSA) Comprehensive were selected in this cross-sectional study. They were separated into different subgroups based on their age groups (i.e., 45-54, 55-64, 65-74, and ≥ 75) and the presence of MCR. Anxiety, mood, and depressive disorders (ADD) were assessed. Depression was defined by the Center for Epidemiological Studies Depression Scale (CES-D) score ≥ 10. The overall prevalence of MCR was 7.0 % and was greater in the youngest age group (8.9 %) as compared to the other age groups (P < 0.05). There was a higher prevalence of ADD and depression in individuals with MCR compared to those without MCR for all age groups (P ≤ 0.001). Depression was significantly associated with MCR regardless of age group (odds ratio ≥ 3.65 with P ≤ 0.001). The association of ADD with MCR depended on the accumulation of disorders and not their type, and was weaker and more inconstant in the oldest age group as compared to younger age groups. MCR is associated with ADD and depression in both younger and older individuals. This association is stronger for depression in younger individuals.

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Baseline Association of Motoric Cognitive Risk Syndrome With Sustained Attention, Memory, and Global Cognition

Cited by 42 publications

References 31 publications

Motoric Cognitive Risk Syndrome in Polypharmacy

Motoric Cognitive Risk Syndrome in Polypharmacy

Compromised prefrontal structure and function are associated with slower walking in older adults

The association of anxio-depressive disorders and depression with motoric cognitive risk syndrome: results from the baseline assessment of the Canadian longitudinal study on aging

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