Baseline brain function in the preadolescents of the ABCD Study

Chaarani, Bader; Hahn, Sage; Allgaier, Nicholas; Adise, Shana; Owens, Max M.; Juliano, Anthony; Yuan, Dekang; Loso, Hannah; Ivanciu, Alexandra; Albaugh, Matthew D.; Dumas, Julie A.; Mackey, Scott; Laurent, Jennifer; Ivanova, Masha Y.; Hagler, Donald J.; Cornejo, M. Daniela; Hatton, Sean N.; Agrawal, Arpana; Aguinaldo, Laika D.; Ahonen, Lia; Aklin, Will M.; Anokhin, Andrey P.; Arroyo, Judith A.; Avenevoli, Shelli; Babcock, Debra; Bagot, Kara; Baker, Fiona C.; Banich, Marie T.; Barch, Deanna M.; Bartsch, Hauke; Baskin‐Sommers, Arielle; Bjork, James M.; Blachman-Demner, D.; Bloch, Michele; Bogdan, Ryan; Bookheimer, Susan Y.; Breslin, Florence J.; Brown, Sandra A.; Calabro, Finnegan J.; Calhoun, Vince D.; Casey, B. J.; Chang, Linda; Clark, Duncan B.; Cloak, Christine; Constable, R. Todd; Constable, K.; Corley, Robin P.; Cottler, Linda B.; Coxe, Stefany; Dagher, Rada K.; Dale, Anders M.; Dapretto, Mirella; DelCarmen-Wiggins, Rebecca; Dick, Anthony Steven; Do, E. K.; Dosenbach, Nico U.F.; Dowling, Gayathri J.; Edwards, Sarah; Ernst, Thomas; Fair, Damien A.; Fan, Chun Chieh; Feczko, Eric; Feldstein-Ewing, Sarah W.; Florsheim, Paul; Foxe, John J.; Freedman, Edward G.; Friedman, Naomi P.; Friedman‐Hill, Stacia R.; Fuemmeler, Bernard F.; Galván, Adriana; Gee, Dylan G.; Giedd, Jay; Glantz, Meyer D.; Glaser, Paul E.A.; Godino, Job G.; Gonzalez, Marybel Robledo; González, Raúl; Grant, Steven; Gray, Kevin M.; Haist, Frank; Harms, Michael P.; Hawes, Samuel W.; Heath, Andrew C.; Heeringa, Steven G.; Heitzeg, Mary M.; Hermosillo, Robert; Herting, Megan M.; Hettema, John M.; Hewitt, John K.; Heyser, Charles J.; Hoffman, Elizabeth A.; Howlett, Katia Delrahim; Huber, Rebekah S.; Huestis, Marilyn A.; Hyde, Luke W.; Iacono, William G.; Infante, M. Alejandra; Irfanoglu, Okan; Isaiah, Amal; Iyengar, Satish; Jacobus, Joanna; James, Regina S.; Jean‐Francois, Beda; Jernigan, Terry L.; Karcher, Nicole R.; Kaufman, Annette; Kelley, Brian M.; Kit, Brian K.; Ksinan, Albert J.; Kuperman, Joshua; Laird, Angela R.; Larson, Christine L.; LeBlanc, Kimberly H.; Lessov-Schlagger, C.; Lever, Nancy; Lewis, David A.; Lisdahl, Krista M.; Little, A. Roger; Lopez, Marsha F.; Luciana, Mónica; Luna, Beatríz; Madden, Pamela A. F.; Maes, Hermine H.; Makowski, Carolina; Marshall, Andrew T.; Mason, Michael; Matochik, John A.; McCandliss, Bruce D.; McGlade, Erin; Montoya, Ivn D.; Morgan, Glen D.; Morris, Amanda Sheffield; Mulford, Carrie F.; Murray, Peggy M.; Nagel, Bonnie J.; Neale, Michael C.; Neigh, Gretchen N.; Nencka, Andrew S.; Noronha, Antonio; Nixon, Sara Jo; Palmer, Clare E.; Pariyadath, Vani; Paulus, Martin P.; Pelham, William E.; Pfefferbaum, Dolf; Pierpaoli, Carlo; Prescot, Andrew P.; Prouty, Devin; Puttler, Leon I.; Rajapaske, N.; Rapuano, Kristina M.; Reeves, Gloria; Renshaw, Perry F.; Riedel, Michael C.; Rojas, Patria; Rosa, Mario De La; Rosenberg, Monica D.; Ross, Michael J.; Sánchez, Mariana; Schirda, Claudiu; Schloesser, Dana; Schulenberg, John E.; Sher, Kenneth J.; Sheth, Chandni; Shilling, Paul D.; Simmons, W. Kyle; Sowell, Elizabeth R.; Speer, Nicole K.; Spittel, Michael; Squeglia, Lindsay M.; Sripada, Chandra; Steinberg, Joel L.; Striley, Catherine; Sutherland, Matthew T.; Tanabe, Jody; Tapert, Susan F.; Thompson, Wesley K.; Tomko, Rachel L.; Uban, Kristina A.; Vrieze, Scott; Wade, Natasha E.; Watts, Richard; Weiss, Susan R.B.; Wiens, Brenda A.; Williams, O. Dale; Wilbur, A.; Wing, David; Wolff-Hughes, Dana L.; Yang, Rongguang; Yurgelun‐Todd, Deborah; Zucker, Robert A.; Potter, Alexandra; Garavan, Hugh

doi:10.1038/s41593-021-00867-9

Cited by 76 publications

(69 citation statements)

References 69 publications

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“…Finally, the high exclusion rate in our replication study resulted in a small sample size, which may lead to lower power and inconsistent estimates. However, the exclusion rate is comparable to other neuroimaging studies [ 55 ]. Even with a small sample, we were able to demonstrate that the task activated reward circuitry.…”

Section: Discussionsupporting

confidence: 81%

A brief child-friendly reward task reliably activates the ventral striatum in two samples of socioeconomically diverse youth

et al. 2022

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Adolescence is a period of increased risk-taking behavior, thought to be driven, in part, by heightened reward sensitivity. One challenge of studying reward processing in the field of developmental neuroscience is finding a task that activates reward circuitry, and is short, not too complex, and engaging for youth of a wide variety of ages and socioeconomic backgrounds. In the present study, we tested a brief child-friendly reward task for activating reward circuitry in two independent samples of youth ages 7–19 years old enriched for poverty (study 1: n = 464; study 2: n = 27). The reward task robustly activated the ventral striatum, with activation decreasing from early to mid-adolescence and increasing from mid- to late adolescence in response to reward. This response did not vary by gender, pubertal development, or income-to-needs ratio, making the task applicable for a wide variety of populations. Additionally, ventral striatum activation to the task did not differ between youth who did and did not expect to receive a prize at the end of the task, indicating that an outcome of points alone may be enough to engage reward circuitry. Thus, this reward task is effective for studying reward processing in youth from different socioeconomic backgrounds.

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Section: Discussionsupporting

confidence: 81%

A brief child-friendly reward task reliably activates the ventral striatum in two samples of socioeconomically diverse youth

et al. 2022

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“…Baseline tests of ABCD have yielded some important discoveries. For instance, resting state functional connectivity patterns predict individual-differences in neurocognition (Sripada et al ., 2020 ), brain activations found in the task functional MRI (fMRI) (Chaarani et al ., 2021 ) are consistent with the published literature, and brain structure have incremental validity for associations with psychopathology in youth (Mattoni et al ., 2021 ). With the progress of ABCD study, it is possible to demystify the longitudinal changes during adolescent brain development and corresponding regulatory factors, and chart typical brain development trajectories across the second decade in life.…”

Section: Cohortssupporting

confidence: 90%

“…With the progress of ABCD study, it is possible to demystify the longitudinal changes during adolescent brain development and corresponding regulatory factors, and chart typical brain development trajectories across the second decade in life. Despite the valuable nature of these data, interpretive issues have arisen regarding aspects of the ABCD baseline brain function study (Chaarani et al ., 2021 ). In brief, the reported effect sizes in the ABCD functional tasks show subtle correlations with preformance on those tasks, which may damage the validity (see also Kennedy et al ., 2021 ).…”

Section: Cohortsmentioning

confidence: 99%

Neuroimaging brain growth charts: A road to mental health

et al. 2021

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Mental disorders are common health concerns and contribute to a heavy global burden on our modern society. It is challenging to identify and treat them timely. Neuroimaging evidence suggests the incidence of various psychiatric and behavioral disorders is closely related to the atypical development of brain structure and function. The identification and understanding of atypical brain development provide chances for clinicians to detect mental disorders earlier, perhaps even prior to onset, and treat them more precisely. An invaluable and necessary method in identifying and monitoring atypical brain development are growth charts of typically developing individuals in the population. The brain growth charts can offer a series of standard references on typical neurodevelopment, representing an important resource for the scientific and medical communities. In the present paper, we review the relationship between mental disorders and atypical brain development from a perspective of normative brain development by surveying the recent progress in the development of brain growth charts, including four aspects on growth chart utility: 1) cohorts, 2) measures, 3) mechanisms, and 4) clinical translations. In doing so, we seek to clarify the challenges and opportunities in charting brain growth, and to promote the application of brain growth charts in clinical practice.

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“…Participants who did not reach acceptable performance in the task were excluded from analysis (indexed by whether all trial types resulted in more than three events for both positive and negative feedback), as well as those whose NAcc activity was above or below three standard deviations. The MID task has been previously validated in typically developing children during fMRI 36 and validation studies for the paradigm and data used in this study have been previous by Casey et al 35 and Chaarani et al 37 Casey et al 35 reported that the experimental manipulation was successful in maintaining hit rates at close to 60%, and that reaction times and payoff amounts were consistent across experimental runs. Chaarani et al 37 reported that the task is associated with robust brain activations which are consistent with the extant literature.…”

Section: Methodsmentioning

confidence: 94%

“…The MID task has been previously validated in typically developing children during fMRI 36 and validation studies for the paradigm and data used in this study have been previous by Casey et al 35 and Chaarani et al 37 Casey et al 35 reported that the experimental manipulation was successful in maintaining hit rates at close to 60%, and that reaction times and payoff amounts were consistent across experimental runs. Chaarani et al 37 reported that the task is associated with robust brain activations which are consistent with the extant literature.…”

Section: Methodsmentioning

confidence: 94%

Reward Processing in Children With Psychotic-Like Experiences

Harju-Seppänen

Irizar

Bramon

et al. 2021

Schizophrenia Bulletin Open

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Alterations to striatal reward pathways have been identified in individuals with psychosis. They are hypothesised to be a key mechanism that generate psychotic symptoms through the production of aberrant attribution of motivational salience and are proposed to result from accumulated childhood adversity and genetic risk, making the striatal system hyper-responsive to stress. However, few studies have examined whether children with psychotic-like experiences (PLEs) also exhibit these alterations, limiting our understanding of how differences in reward processing relate to hallucinations and delusional ideation in childhood. Consequently, we examined whether PLEs and PLE-related distress were associated with reward-related activation in the nucleus accumbens (NAcc). The sample consisted of children (N = 6,718) from the Adolescent Brain Cognitive Development (ABCD) study aged 9-10 years who had participated in the Monetary Incentive Delay (MID) task in functional MRI. We used robust mixed-effects linear regression models to investigate the relationship between PLEs and NAcc activation during the reward anticipation and reward outcome stages of the MID task. Analyses were adjusted for gender, household income, ethnicity, depressive symptoms, movement in the scanner, pubertal development, scanner ID, subject and family ID. There was no reliable association between PLEs and alterations to anticipation-related or outcome-related striatal reward processing. We discuss the implications for developmental models of psychosis and suggest a developmental delay model of how PLEs may arise at this stage of development.

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Baseline brain function in the preadolescents of the ABCD Study

Cited by 76 publications

References 69 publications

A brief child-friendly reward task reliably activates the ventral striatum in two samples of socioeconomically diverse youth

A brief child-friendly reward task reliably activates the ventral striatum in two samples of socioeconomically diverse youth

Neuroimaging brain growth charts: A road to mental health

Reward Processing in Children With Psychotic-Like Experiences

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