Baseline characteristics of participants in the Longitudinal Assessment of Bariatric Surgery-2 (LABS-2) study

Belle, Steven H.; Berk, Paul D.; Chapman, William H.; Christian, Nicholas J.; Courcoulas, Anita P.; Dakin, Greg; Flum, David R.; Horlick, Mary; King, Wendy C.; McCloskey, Carol; Mitchell, James E.; Patterson, Emma; Pender, John R.; Steffen, Kristine J.; Thirlby, Richard C.; Wolfe, Bruce M.; Yanovski, Susan Z.

doi:10.1016/j.soard.2013.01.023

Cited by 111 publications

(135 citation statements)

References 34 publications

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“…The LABS study design is detailed elsewhere [26][27][28]. LABS-2 is investigating the long-term effects of bariatric surgery on patients' weight, as well as physical and mental health status.…”

Section: Methodsmentioning

confidence: 99%

Sexual functioning and sex hormones in men who underwent bariatric surgery

Sarwer

Spitzer

Wadden

et al. 2015

Surgery for Obesity and Related Diseases

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Men who lost approximately one third of their weight after Roux-en-Y gastric bypass experienced significant increases in total testosterone and SHBG. They did not, however, report significant improvements in sexual functioning, relationship satisfaction, or mental health domains of HRQoL. This pattern of results differs from that of women who have undergone bariatric surgery, who reported almost uniform improvements in sexual functioning and psychosocial status.

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Section: Methodsmentioning

confidence: 99%

Sexual functioning and sex hormones in men who underwent bariatric surgery

Sarwer

Spitzer

Wadden

et al. 2015

Surgery for Obesity and Related Diseases

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“…The initial LABS study, (LABS-1) involved 5,050 patients and examined the short-term safety of bariatric surgery (18). LABS-2 examined long-term efficacy of bariatric surgery in 2,458 patients (19). The current study, (LABS-3 Psychosocial), was conducted in a smaller set of participants (n=202), many of whom also participated in LABS-2, at three of the six LABS-2 clinical centers: The Neuropsychiatric Research Institute, Fargo, ND; Columbia-Weill Cornell Medical Centers in New York, NY; and the University of Pittsburgh in PA.…”

Section: Design Setting and Participantsmentioning

confidence: 99%

Psychiatric Disorders and weight Change in a Prospective Study of Bariatric Surgery Patients: A 3-Year Follow-Up

Kalarchian

King

Devlin

et al. 2015

Surgery for Obesity and Related Diseases

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“…Detailed comoribity definitions are available in the online Supplemental Information, and the technical details pertaining to assays have also been previously described. 9 Excluding PCOS, which only applies to female patients, and hyperlipidemia, which is a subset of dyslipidemia, the number of major comoribidities was summed (possible range: 0-11) to provide a rough estimate of disease burden. Disease severity was not taken into account and all diseases were weighted equally.…”

Section: Demographics Bmi and Health Status At Time Of Labs-2 Enrolmentioning

confidence: 99%

The Effect of Obesity in Adolescence on Adult Health Status

King²,

et al. 2013

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WHAT'S KNOWN ON THIS SUBJECT: Adverse effects of excess weight are likely related to both obesity severity and duration. Little is known about the contribution of adolescent weight status to development of specific comorbid conditions in adults.WHAT THIS STUDY ADDS: Severe obesity at age 18 was independently associated with increased risk of lower extremity venous edema, walking limitation, kidney dysfunction, polycystic ovary syndrome, respiratory conditions, diabetes, and hypertension in adulthood.abstract OBJECTIVE: To test the hypothesis that adolescent obesity would be associated with greater risks of adverse health in severely obese adults. METHODS:Before weight loss surgery, adult participants in the Longitudinal Assessment of Bariatric Surgery-2 underwent detailed anthropometric and comorbidity assessment. Weight status at age 18 was retrospectively determined. Participants who were $80% certain of recalled height and weight at age 18 (1502 of 2308) were included. Log binomial regression was used to evaluate whether weight status at age 18 was independently associated with risk of comorbid conditions at time of surgery controlling for potential confounders.RESULTS: Median age and adult body mass index (BMI) were 47 years and 46, respectively. At age 18, 42% of subjects were healthy weight, 29% overweight, 16% class 1 obese, and 13% class $2 obese. Compared with healthy weight at age 18, class $2 obesity at age 18 independently increased the risk of lower-extremity venous edema with skin manifestations by 435% (P , .0001), severe walking limitation by 321% (P , .0001), abnormal kidney function by 302% (P , .0001), polycystic ovary syndrome by 74% (P = .03), asthma by 48% (P = .01), diabetes by 42% (P , .01), obstructive sleep apnea by 25% (P , .01), and hypertension (by varying degrees based on age and gender). Conversely, the associated risk of hyperlipidemia was reduced by 61% (P , .01). CONCLUSIONS:Severe obesity at age 18 was independently associated with increased risk of several comorbid conditions in adults undergoing bariatric surgery. Dr Inge conceptualized and designed the study, drafted the initial manuscript, and revised the manuscript; Dr King drafted the initial manuscript, carried out the initial analyses and revised the manuscript; Ms Chen carried out the initial analyses and reviewed and revised the manuscript, and approved the final manuscript as submitted; Dr Mitsnefes assisted with analysis and interpretation of metabolic data and critically reviewed and revised the manuscript; Dr Daniels substantially contributed to analysis and interpretation of cardiovascular risk factor data and critically reviewed and revised the manuscript; Drs Zeller and Horlick substantially contributed to the conception and design of the study and critically reviewed and revised the manuscript; Dr Khandelwal substantially contributed acquisition of data and critically reviewed and revised the manuscript; Dr Jenkins substantially contributed to the study design and analysis of data and critically reviewed and r...

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Baseline characteristics of participants in the Longitudinal Assessment of Bariatric Surgery-2 (LABS-2) study

Cited by 111 publications

References 34 publications

Sexual functioning and sex hormones in men who underwent bariatric surgery

Sexual functioning and sex hormones in men who underwent bariatric surgery

Psychiatric Disorders and weight Change in a Prospective Study of Bariatric Surgery Patients: A 3-Year Follow-Up

The Effect of Obesity in Adolescence on Adult Health Status

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