Baseline High Blood Pressure is Associated with Clinico-Pathologic Findings and Later Renal Progression in Chronic Glomerulonephritis

Lee, Ji Yung; Ihm, Hyung-Seok; Kim, Jin Sug; Hwang, Hyeon Seok; Jeong, Kyung Hwan; Ihm, Chun-Gyoo

doi:10.5049/ebp.2019.17.2.54

Cited by 3 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, HBP can also damage the vascular structure in many ways, such as stress shock, vascular remodeling, inflammatory reaction and so on, which can accelerate the progression of IgAN and affect the prognosis of IgAN ( 20 ). For example, HBP may cause damage of normal renal vascular structure, leading to glomerular hypertrophy and renal tubulointerstitial fibrosis in IgAN patients ( 21 ). The enlargement of glomerulus increases the tensile stress on the podocyte foot process covering capillaries, which leads to podocyte damage, loss of glomerular barrier function, proteinuria, glomerulosclerosis and gradual loss of renal function.…”

Section: Discussionmentioning

confidence: 99%

The causal effect of triglyceride and high blood pressure on IgA nephropathy: a Mendelian randomization study

Yang,

Li,

Feng

et al. 2024

Front. Med.

View full text Add to dashboard Cite

BackgroundIt has been reported that high blood pressure (HBP) and triglyceride (TG) are considered risk factors in immunoglobulin A nephropathy (IgAN). This study aimed to explore the causalities between HBP and TG, and IgAN on the basis of Mendelian randomization (MR) analysis.MethodsFirstly, the genome-wide association study (GWAS) summary data of IgAN (GCST90018866) and two exposure factors, TG (ukb-d-30870_raw) and HBP (ukb-a-437), were sourced from the GWAS Catalog and Integrative Epidemiology Unit (IEU) OpenGWAS databases, respectively. In this study, five methods were utilized to perform MR analysis after picking out single nucleotide polymorphisms (SNPs) as instrumental variables, including MR-Egger, weighted median, simple mode, weighted mode, and inverse variance weighted (IVW), followed by the sensitivity analysis containing the heterogeneity, horizontal pleiotropy test and leave-one-out (LOO) analysis. Finally, the enrichment analysis and interaction network construction of genes corresponding to SNPs of HBP and TG were performed.ResultsThe univariate MR results revealed that HBP and TG regarded as risk factors were causally related to IgAN [TG: p = 0.046, odds ratio (OR) = 1.065, 95% confidence interval (CI) = 1.001–1.133; HBP: p = 7.09 × 10−7, OR = 1.970, 95% CI = 1.507–2.575] based on random-effect IVM method, of which TG had a weaker impact. The reliability of these univariate MR results was certified by the sensitivity analysis, in which there was no horizontal pleiotropy and exaggerated influence of each SNP. Furthermore, HBP was markedly causally related to IgAN (p = 0.000512) with the help of multivariate MR analysis, rather than TG (p = 0.332). Therefore, when HBP and TG occur simultaneously, HBP is a direct influencing factor on IgAN. Ultimately, a total of 208 and 153 genes separately corresponding to SNPs of TG and HBP were included in enrichment analysis, and thereinto, genes relevant to TG were mainly enriched in lipid homeostasis and cholesterol metabolism, while genes concerned with HBP played their roles in regulation of cell growth, aldosterone synthesis and secretion and so forth.ConclusionTG and HBP as risk factors were causally connected with IgAN, of which HBP was strongly related to the onset of IgAN, providing more reliable evidence for further exploring the relationship between TG and HBP and IgAN.

show abstract

Section: Discussionmentioning

confidence: 99%

The causal effect of triglyceride and high blood pressure on IgA nephropathy: a Mendelian randomization study

Yang,

Li,

Feng

et al. 2024

Front. Med.

View full text Add to dashboard Cite

show abstract

“…Additionally, vice versa, a progressive decrease in GFR during the course of different kidney diseases inevitably leads to an increase in systemic blood pressure. It is well known that glomerulonephritis, or diabetic kidney disease, can lead to an increase in systemic blood pressure [ 54 , 55 , 56 , 57 , 58 ]. Moreover, the reduced area of the renal cortex arteries estimated in DTPM can help to differentiate between hypertensive nephropathy and glomerulonephritis [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Renal Disturbances during and after Radioligand Therapy of Neuroendocrine Tumors—Extended Analysis of Potential Acute and Chronic Complications

Saracyn¹,

Durma²,

Bober³

et al. 2023

IJMS

View full text Add to dashboard Cite

Neuroendocrine tumors (NEN) are a group of neoplasms that arise from hormonal and neural cells. Despite a common origin, their clinical symptoms and outcomes are varied. They are most commonly localized in the gastrointestinal tract. Targeted radioligand therapy (RLT) is a treatment option which has proven to be successful in recent studies. However, the possible outcomes and true safety profile of the treatment need to be fully determined, especially by new, more sensitive methods. Our study aimed to present an extended analysis of acute and chronic renal complications during and after radioligand therapy using, for the first time in the literature, innovative and complex renal parameters. Forty patients with neuroendocrine tumors underwent four courses of radioligand therapy with [177Lu]Lu-DOTATATE or [177Lu]Lu/[90Y]Y-DOTATATE. Radioisotopes were administrated in intervals of 8–12 weeks, with concurrent intravenous nephroprotection. New detailed and sensitive renal parameters were used to determine the renal safety profile during and after radioisotope therapy for standard treatment of NEN. During the first and fourth courses of RLT, no change in the glomerular filtration rate (GFR) was observed. However, long-term observations one year after the treatment showed a 10% reduction in the GFR. During the first course of treatment, the fractional urea and calcium excretions increased, while the fractional potassium concentration decreased. The fractional calcium excretion remained highly increased in long-term observations. Decreases in urine IL-18, KIM-1 and albumin concentrations were observed during RLT. The concentrations of IL-18 and KIM-1 remained low even a year after therapy. The ultrasound parameters of renal perfusion changed during treatment, before partially returning to the baseline one year after therapy, and were correlated with the biochemical parameters of renal function. A permanent increase in diastolic blood pressure was correlated with the decrease in the GFR observed during the study. In this innovative and complex renal assessment during and after RLT, we found a permanent 10% per year decrease in the GFR and noticeable disturbances in renal tubule function. The diastolic blood pressure also increased.

show abstract

Fibroblasts, Fibrosis and Autophagy

Chattopadhyaya

Czubryt

2021

Biochemistry of Apoptosis and Autophagy

View full text Add to dashboard Cite

Baseline High Blood Pressure is Associated with Clinico-Pathologic Findings and Later Renal Progression in Chronic Glomerulonephritis

Cited by 3 publications

References 25 publications

The causal effect of triglyceride and high blood pressure on IgA nephropathy: a Mendelian randomization study

The causal effect of triglyceride and high blood pressure on IgA nephropathy: a Mendelian randomization study

Renal Disturbances during and after Radioligand Therapy of Neuroendocrine Tumors—Extended Analysis of Potential Acute and Chronic Complications

Fibroblasts, Fibrosis and Autophagy

Contact Info

Product

Resources

About