Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development

Bopp, Nathen E.; Kaiser, Jaclyn A.; Strother, Ashley E.; Barrett, Alan D.T.; Benassi, Virginia; Milligan, Gregg N.; Preziosi, Marie Pierre; Reece, Lisa M.

doi:10.1038/s41541-020-00257-5

Cited by 35 publications

(30 citation statements)

References 136 publications

(319 reference statements)

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“…These aberrantly altered parameters are indicative of pathological lesions in the heart, kidney, liver, and coagulation systems of SFTS positive patients. In SFTS, hepatocytes were found to be not infected with SFTSV, while several SFTSV-NP antigen-positive cells were detected in the liver [ 19 , 20 ]. In this view, it is demonstrated that in SFTS positive patients, the liver damage might be due to a subordinate pathological event rather than due to direct destruction caused by SFTSV.…”

Section: Discussionmentioning

confidence: 99%

The associations between fasting blood glucose levels and mortality of SFTS in patients

Zhang

Huang

2021

BMC Infect Dis

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Objective To identify the correlation between the level of at-admission fasting blood glucose (FBG) with poor outcomes in hospitalized patients suffering from severe fever with thrombocytopenia syndrome (SFTS). Methods Between April 1 and December 1, 2020, the list of hospitalized patients affected with SFTS infection was provided by the Infectious Disease Department at First Affiliated Hospital of Anhui Medical University, followed by the collection of information I.e., gender, age, diabetic history and the level of FBG on admission. Results In this study, a total of 77 patients were included and were categorized into three groups (< 5.6, 5.6–6.9, and ≥ 7.0 mmol/l) on the basis of their glucose level in the blood. The obtained results revealed that among three groups considerable variations were observed in leukocytes, FBG, D-Dimer, aspartate aminotransferase (AST), tumor necrosis factor-α (TNF-α), fibrin degradation products (FDP), and interleukin (IL)-10 level. Correlation analysis indicated a linear negative correlation between PLT and FBG (r = − 0.28, P = 0.01), however, a linear positive correlation was observed between AST, IL10, D-Dimer, and FDP levels and FBG (P-value < 0.05). Multivariate statistical analysis results shown that there was significant difference between group comparison (F = 17.01, P < 0.001) and interaction between group and time (F = 8.48, P < 0.05); but there was no significant difference between time point comparison (F = 0.04, P = 0.96). With the prolongation of time, the changes of FBG were different between survivor group and non-survivor group. The FBG in survival group shown a downward trend; The non-survivor group shown an upward trend. Conclusions Elevated level of FBG has been correlated with hypercoagulability, inflammation, and lower PLT in SFTS patients. The measurement of FBG level can help in evaluating the inflammatory process, hypercoagulability, and prognosis of patients suffering from SFTS. FBG can predict the prognosis of SFTS. It is necessary to pay attention to the role of FBG in the process of treatment in patients with SFTS.

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Section: Discussionmentioning

confidence: 99%

The associations between fasting blood glucose levels and mortality of SFTS in patients

Zhang

Huang

2021

BMC Infect Dis

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“…Although tick-vectors of SFTS are found in a wide geographic area, SFTS has only been reported from limited Southeast Asia such as China, South Korea, Vietnam, and Japan. However, it may become more prominent in the future due to the increased international communication and the expansion of the areas where the vectors can live [8]. Crimean-Congo hemorrhagic fever is another tick-borne viral hemorrhagic fever currently found in Europe, Asia, Africa, the Middle East, and the Indian subcontinent.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Viral-Induced Inflammatory Coagulation Disorders: Preparing for Another Epidemic

2021

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A number of viral infectious diseases have emerged or reemerged from wildlife vectors that have generated serious threats to global health. Increased international traveling and commerce increase the risk of transmission of viral or other infectious diseases. In addition, recent climate changes accelerate the potential spread of domestic disease. The Coronavirus disease 2019 (COVID-19) pandemic is an important example of the worldwide spread, and the current epidemic will unlikely be the last. Viral hemorrhagic fevers, such as Dengue and Lassa fevers, may also have the potential to spread worldwide with a significant impact on public health with unpredictable timing. Based on the important lessons learned from COVID-19, it would be prudent to prepare for future pandemics of life-threatening viral diseases. Among the various threats, this review focuses on the coagulopathy of acute viral infections since hypercoagulability has been a major challenge in COVID-19, but represents a different presentation compared to viral hemorrhagic fever. However, both thrombosis and hemorrhage are understood as the result of thromboinflammation due to viral infections, and the role of anticoagulation is important to consider.

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“…The causative agent of SFTS is a novel phlebovirus in the Bunyaviridae family, which was named SFTS virus (SFTSV) ( Yu et al, 2011 ). Since its initial discovery, SFTS has been epidemic in more than 20 provinces in China, which has threatened the health of Chinese people seriously ( Guo et al, 2016 ; Zhan et al, 2017 ; Bopp et al, 2020 ; Li et al, 2021 ). Anhui province has shown a higher disease burden of SFTS ( Zhan et al, 2017 ; Bopp et al, 2020 ; Li et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Since its initial discovery, SFTS has been epidemic in more than 20 provinces in China, which has threatened the health of Chinese people seriously ( Guo et al, 2016 ; Zhan et al, 2017 ; Bopp et al, 2020 ; Li et al, 2021 ). Anhui province has shown a higher disease burden of SFTS ( Zhan et al, 2017 ; Bopp et al, 2020 ; Li et al, 2021 ). Besides China, SFTSV infections have also been confirmed in Japan, South Korea, Vietnam, and Pakistan ( Li, 2015 ; Tran et al, 2019 ; Bopp et al, 2020 ; Miao et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Anhui province has shown a higher disease burden of SFTS ( Zhan et al, 2017 ; Bopp et al, 2020 ; Li et al, 2021 ). Besides China, SFTSV infections have also been confirmed in Japan, South Korea, Vietnam, and Pakistan ( Li, 2015 ; Tran et al, 2019 ; Bopp et al, 2020 ; Miao et al, 2020 ). The virus was not only transmitted by tick bites but although by person-to-person transmission ( Gong et al, 2018 ; Jung et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Time Course of Severe Fever With Thrombocytopenia Syndrome Virus and Antibodies in Patients by Long-Term Follow-Up Study, China

Kong

Liu

et al. 2021

Front. Microbiol.

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Objectives: The objective was to describe the changes of severe fever with thrombocytopenia syndrome virus (SFTSV) and antibody in the disease course and explore the relationship between antibody titers and patients’ prognosis.Methods: The levels of SFTSV, virus-specific immunoglobulin M (IgM), immunoglobulin G (IgG) titers, and cytokines in 37 patients with severe fever with thrombocytopenia syndrome (SFTS) were measured dynamically by real-time PCR and ELISA during the disease course; IgG titers were followed up in 53 cases. The correlation analysis of antibody titers with individual serum cytokines was calculated using the Spearman test.Results: The average time of SFTSV duration in individual serum was 22.45 ± 7.6 days from onset. We found SFTSV turned negative within the 10th day from the onset in two patients. SFTSV-specific IgM seroconversion occurred as early as within 3 days from the onset, increased gradually within the first 2 months, decreased gradually 3 months later, and disappeared after 6 months in all the patients. The average time of SFTSV-specific IgG antibody seroconversion was at 17 days from onset in the patients; the time was later in severe cases than in mild cases (23 ± 1.4 vs. 14.3 ± 1.0 days, p < 0.0001). IgG titers were maintained at the peak levels during the periods from 6 months to 1 year and decreased from the second year gradually. Severe cases had higher IgG levels than mild cases and also had a slower decreasing trend. During follow-up, only one lost IgG antibody 7 years later; no chronic infection and sequela were found among the 53 patients. None of the patients had SFTSV reinfection even if they were bitten by ticks again. The correlation analysis showed a positive relationship between inflammatory factors and IgG antibody levels.Conclusion: IgM antibody has important value in early diagnosis of SFTS. A moderate inflammatory response is beneficial for production and duration of IgG antibodies.

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Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development

Cited by 35 publications

References 136 publications

The associations between fasting blood glucose levels and mortality of SFTS in patients

The associations between fasting blood glucose levels and mortality of SFTS in patients

Viral-Induced Inflammatory Coagulation Disorders: Preparing for Another Epidemic

Time Course of Severe Fever With Thrombocytopenia Syndrome Virus and Antibodies in Patients by Long-Term Follow-Up Study, China

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