Baseline Prognostic Factors Predict Rapid Visual Field Deterioration in Glaucoma

Lee, Jun Mo; Caprioli, Joseph; Nouri‐Mahdavi, Kouros; Afifi, Abdelmonem A.; Morales, Esteban; Ramanathan, Meera; Yu, Fei; Coleman, Anne L.

doi:10.1167/iovs.13-12261

Cited by 50 publications

(37 citation statements)

References 21 publications

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“…Recent studies have reported that CH is a stronger risk factor for the progression of glaucoma than CCT26, and indeed, in the current study, CH was included in both model ORA and model ORA_CST . Baseline VF damage may43949 or may not405051 be related to faster VF progression; however, in the current study, mTD in the initial VF was not included in any of the optimal models.…”

Section: Discussionmentioning

confidence: 90%

The usefulness of CorvisST Tonometry and the Ocular Response Analyzer to assess the progression of glaucoma

Hirasawa

Murata

Nakakura³

et al. 2017

Sci Rep

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Glaucoma is the second leading cause of blindness worldwide, affecting approximately 60 million peoples 1 . The disease causes irreversible visual field (VF) damage so it is very important to predict its progression and make appropriate interventions as soon as possible. The principal target of glaucoma treatments is to reduce and control intraocular pressure (IOP), which has been shown to reduce VF progression by numerous clinical trials and research studies 2-10 . Tonometry measurements of IOP can be greatly influenced by structural properties of the eye; in particular, IOP measured with Goldmann applanation tonometry (GAT) has been shown to be affected by central corneal thickness (CCT) [11][12][13][14][15][16][17][18][19][20][21][22][23] . Thus, CCT should be considered when interpreting GAT-measured IOP and making clinical decisions. Furthermore, studies have suggested that CCT is associated with the progression of glaucoma 4,24 . Other biomechanical properties of the cornea have also been shown to affect the progression of glaucoma. In particular, corneal hysteresis (CH) and corneal resistance factor (CRF), measured with the Ocular Response Analyzer (ORA, Reichert Ophthalmic Instruments, Depew, NY, USA), have been reported to impinge on progression 25,26 .The Corneal Visualization Scheimpflug Technology instrument (Corvis ST tonometry: CST; Oculus, Wetzlar, Germany) is a new device, integrated with an ultra-high-speed Scheimpflug camera, to quantitatively measure biomechanical properties of the cornea during the application of a rapid air-puff 27 . As a result, very detailed corneal movement during the air puff application can be observed, such as velocity of corneal deformation at the first and second applanations and the maximum depth of corneal deformation (Fig. 1). Although CST and ORA both measure the biomechanical properties of the cornea, their mechanisms are completely different, and the relationship between CST-measured corneal parameters and the progression of glaucomatous VF damage

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Section: Discussionmentioning

confidence: 90%

The usefulness of CorvisST Tonometry and the Ocular Response Analyzer to assess the progression of glaucoma

Hirasawa

Murata

Nakakura³

et al. 2017

Sci Rep

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“…[7, 13] Similarly, in another study, self-described race was no longer a significant predictor of “fast VF progression,” defined as a component decay rate of ≥36%/y, when baseline cup disc ratio and VF parameters were included in the multivariable model. [23, 24] These studies did not specifically examine the interaction between race and IOP in predicting the development of VF damage.…”

Section: Discussionmentioning

confidence: 99%

The African Descent and Glaucoma Evaluation Study (ADAGES): Predictors of Visual Field Damage in Glaucoma Suspects

Khachatryan

Medeiros

Sharpsten

et al. 2015

American Journal of Ophthalmology

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Purpose To evaluate racial differences in the development of visual field (VF) damage in glaucoma suspects. Design Prospective, observational cohort study. Methods Six hundred thirty six eyes from 357 glaucoma suspects with normal VF at baseline were included from the multicenter African Descent and Glaucoma Evaluation Study (ADAGES). Racial differences in the development of VF damage were examined using multivariable Cox Proportional Hazard models. Results Thirty one (25.4%) of 122 African descent participants and 47 (20.0%) of 235 European descent participants developed VF damage (p=0.078). In multivariable analysis, worse baseline VF mean deviation, higher mean arterial pressure during follow up, and a race *mean intraocular pressure (IOP) interaction term were significantly associated with the development of VF damage suggesting that racial differences in the risk of VF damage varied by IOP. At higher mean IOP levels, race was predictive of the development of VF damage even after adjusting for potentially confounding factors. At mean IOPs during follow-up of 22, 24 and 26 mmHg, multivariable hazard ratios (95%CI) for the development of VF damage in African descent compared to European descent subjects were 2.03 (1.15–3.57), 2.71 (1.39–5.29), and 3.61 (1.61–8.08), respectively. However, at lower mean IOP levels (below 22 mmHg) during follow-up, African descent was not predictive of the development of VF damage. Conclusion In this cohort of glaucoma suspects with similar access to treatment, multivariate analysis revealed that at higher mean IOP during follow-up, individuals of African descent were more likely to develop VF damage than individuals of European descent.

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“…[27,28] Explanations for this relationship require further investigation but may have to do with ethnic differences in central corneal thickness, [29] IOP, stage at diagnosis, or medication adherence, [30,31] which themselves are risk factors for glaucoma or glaucoma progression. [5,6,32] Haitian participants did have a somewhat higher treated maximum IOP (mean = 19.5) than white participants (mean = 18.7) but not statistically significantly so.…”

Section: Discussionmentioning

confidence: 99%

Maladaptive coping strategies and glaucoma progression

Freeman

Lesk²,

Harasymowycz³

et al. 2016

Medicine

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The identification of modifiable risk factors for glaucoma progression is needed. Our objective was to determine whether maladaptive coping styles are associated with recent glaucoma progression or worse visual field mean deviation.A hospital-based case–control study was conducted in the Glaucoma Service of Maisonneuve-Rosemont Hospital in Montreal, Canada. Patients with primary open angle glaucoma or normal tension glaucoma with ≥4 years of follow-up and ≥5 Humphrey visual fields were included. Cases had recent visual field progression as defined according to the Early Manifest Glaucoma Trial pattern change probability maps. Controls had stable visual fields. The Brief Cope questionnaire, a 28-item questionnaire about 14 different ways of coping with the stress of a chronic disease, was asked. Questions were also asked about demographic and medical factors, and the medical chart was examined. Outcomes included glaucoma progression (yes, no) and visual field mean deviation. Logistic and linear regressions were used.A total of 180 patients were included (82 progressors and 98 nonprogressors). Although none of the 14 coping scales were associated with glaucoma progression (P > 0.05), higher denial was correlated with worse visual field mean deviation (r = −0.173, P = 0.024). In a linear regression model including age, sex, education, depression, intraocular pressure, and family history of glaucoma, greater levels of denial (β = −1.37, 95% confidence interval [CI] −2.32, −0.41), Haitian ethnicity (β = −7.78, 95% CI −12.52, −3.04), and the number of glaucoma medications (β = −1.20, 95% CI −2.00, −0.38) were statistically significantly associated with visual field mean deviation.The maladaptive coping mechanism of denial was a risk factor for worse visual field mean deviation. Further prospective research will be required to verify the pathways by which denial may exert an effect on glaucomatous visual field loss.

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Baseline Prognostic Factors Predict Rapid Visual Field Deterioration in Glaucoma

Cited by 50 publications

References 21 publications

The usefulness of CorvisST Tonometry and the Ocular Response Analyzer to assess the progression of glaucoma

The usefulness of CorvisST Tonometry and the Ocular Response Analyzer to assess the progression of glaucoma

The African Descent and Glaucoma Evaluation Study (ADAGES): Predictors of Visual Field Damage in Glaucoma Suspects

Maladaptive coping strategies and glaucoma progression

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