Basement membrane heterogeneity

Bosman, Fred T.; Cleutjens, Jack P.M.; Beek, C.; Havenith, M. G.

doi:10.1007/bf01002481

Cited by 44 publications

(18 citation statements)

References 34 publications

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“…It is perhaps significant that laminin was affected as it is perhaps the most important macromolecule responsible for basal cell to basement membrane attachment in skin. 22,23,24 No reports currently exist concerning the possible effects of SM-induced protease release on basement membrane components. Laminin is known to be susceptible to proteases such as pepsin and trypsin.25…”

Section: Discussionmentioning

confidence: 98%

Changes in connective tissue macromolecular components of Yucatan mini-pig skin following application of sulphur mustard vapour

Lindsay

Rice

1995

Hum Exp Toxicol

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1 The aim of this study was to determine the nature of the macromolecular alterations in Yucatan mini-pig skin which occur following application of sulphur mustard vapour, with particular reference to laminin and type IV collagen. 2 The immunostaining of transfer blots from skin extracts run on SDS-PAGE gels revealed no evidence of cross-link ing of type IV collagen or laminin. Laminin was, however, found to be partially degraded as determined by the reso lution of 132 and 143 kDa fragments, possibly by the acti vation of proteases, following the application of sulphur mustard to pig skin. Type IV collagen was not subject to this form of degradation in the skin samples exposed to sulphur mustard. 3 Yucatan mini-pig skin was found to develop microblis ters after exposure to sulphur mustard vapour. The immunohistochemical studies of sulphur mustard exposed skin revealed that separation of the epidermis from the dermis was found to occur within the lamina lucida of the subepidermal basement membrane, supporting the con tention that cleavage of laminin networks occurs following mustard challenge. Immunohistochemical staining with anti-type IV collagen antibodies was restricted to the floor of the micro-blister lesions. 4 The results suggest that laminin may be a target for pro tease activation at the dermo-epidermal junction. This may account for the tendency of certain skin models to develop sulphur mustard-induced blistering. The Yucatan mini-pig may be valuable as a model to determine the effi cacy of prophylactic and therapeutic regimes.

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Section: Discussionmentioning

confidence: 98%

Changes in connective tissue macromolecular components of Yucatan mini-pig skin following application of sulphur mustard vapour

Lindsay

Rice

1995

Hum Exp Toxicol

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“…Because collagen IV is an integral part of the extracellular matrix and provides stability to the microvasculature, however, its loss might be expected to increase microvascular permeability and to compromise vascular wall integrity in SAH as observed in other cerebral ischemia. 9,61 In this regard it is notable that increased capillary permeability and BBB opening are observed as early as 2 to 3 hours after SAH in other experimental SAH models. 17,18,34 A clearer understanding of the physiological implications of our observations will require analysis of BBB function in our endovascular model of SAH.…”

Section: Increase In Collagenase Activity and Mmp-9 Immunoreactivity mentioning

confidence: 92%

Acute alterations in microvascular basal lamina after subarachnoid hemorrhage

Sehba

Mostafa²,

Knopman³

et al. 2004

Journal of Neurosurgery

117

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“…The authors noted colocalization of MMP-9 upregulation and collagen IV degradation [31]. Collagen IV is a major structural component of the basal lamina, comprising approximately 90% of the total protein [32, 33]. They concluded that MMP-9 may play a role in BBB permeability [31].…”

Section: Mmp Reviewmentioning

confidence: 99%

Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage

Mehta

Russin

Spirtos

et al. 2013

Neurology Research International

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Delayed cerebral vasospasm is a significant cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). While the cellular mechanisms underlying vasospasm remain unclear, it is believed that inflammation may play a critical role in vasospasm. Matrix metalloproteinasees (MMPs) are a family of extracellular and membrane-bound proteases capable of degrading the blood-rain barrier (BBB). As such, MMP upregulation following SAH may result in a proinflammatory extravascular environment capable of inciting delayed cerebral vasospasm. This paper presents an overview of MMPs and describes existing data pertinent to delayed cerebral vasospasm.

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Basement membrane heterogeneity

Cited by 44 publications

References 34 publications

Changes in connective tissue macromolecular components of Yucatan mini-pig skin following application of sulphur mustard vapour

Changes in connective tissue macromolecular components of Yucatan mini-pig skin following application of sulphur mustard vapour

Acute alterations in microvascular basal lamina after subarachnoid hemorrhage

Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage

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