Basement Membranes in Development and Disease

Sekiguchi, Rei; Yamada, Kenneth M.

doi:10.1016/bs.ctdb.2018.02.005

Cited by 171 publications

(157 citation statements)

References 229 publications

(285 reference statements)

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“…6 In the BBB, the BM comprises a complex network of extracellular matrix (ECM) molecules such as type IV collagen, laminins, fibronectin, heparan sulphate and proteoglycans. 1,7,8 BM facilitates the intercellular interactions in a highly dynamic environment and undergoes transformations throughout animal life 9 and it is particularly important in transport across the BBB. An increasing body of evidence derived from both human and animal samples suggests that age-associated cognitive decline in the absence of comorbidities is a consequence of specific changes in both composition and structure of the BBB, which may disrupt the barrier function and compromise molecular trafficking.…”

Section: Introductionmentioning

confidence: 99%

Age‐related ultrastructural changes of the basement membrane in the mouse blood‐brain barrier

Ceafalan

Fertig

Gheorghe

et al. 2018

J Cellular Molecular Medi

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The blood‐brain barrier (BBB) is essential for a functional neurovascular unit. Most studies focused on the cells forming the BBB, but very few studied the basement membrane (BM) of brain capillaries in ageing. We used transmission electron microscopy and electron tomography to investigate the BM of the BBB in ageing C57BL/6J mice. The thickness of the BM of the BBB from 24‐month‐old mice was double as compared with that of 6‐month‐old mice (107 nm vs 56 nm). The aged BBB showed lipid droplets gathering within the BM which further increased its thickness (up to 572 nm) and altered its structure. The lipids appeared to accumulate toward the glial side of the BM. Electron tomography showed that the lipid‐rich BM regions are located in small pockets formed by the end‐feet of astrocytes. These findings suggest an imbalance of the lipid metabolism and that may precede the structural alteration of the BM. These alterations may favour the accretion of abnormal proteins that lead to neurodegeneration in ageing. These findings warrant further investigation of the BM of brain capillaries and of adjoining cells as potential targets for future therapies.

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Section: Introductionmentioning

confidence: 99%

Age‐related ultrastructural changes of the basement membrane in the mouse blood‐brain barrier

Ceafalan

Fertig

Gheorghe

et al. 2018

J Cellular Molecular Medi

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“…Laminin–integrin interactions can be observed on both nerve and muscle sides of the BM and play critical roles in the formation and function of neuromuscular junctions 52, 53 . Moreover, COL7 is absent from lung alveoli, blood vessels and kidneys, where different tissues are tightly integrated via the BM that places laminins at both its sides 1, 2, 54, 55, 56 . Thus, it is likely that the absence of the reticular lamina enables the placement of laminins on both sides of the BM.…”

Section: Discussionmentioning

confidence: 99%

“…The extracellular matrix (ECM) is a complex noncellular network of multicellular organisms that plays essential roles in animal development and homeostasis. The basement membrane (BM) is a thin sheet-like ECM that is located at the border of tissues, where it serves to compartmentalize and also tightly integrate tissues 1, 2 . The BM has several crucial roles: i) it provides structural support to cells that is essential for the development of organ structures; ii) it signals to cells through adhesion receptors such as integrins; iii) it controls the tissue distributions and activities of soluble growth factors; and iv) its mechanical characteristics influence cell behavior 3, 4, 5 .…”

Section: Introductionmentioning

confidence: 99%

Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions

Tsutsui

Machida

Morita

et al. 2020

Preprint

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21Inter-tissue interaction is fundamental to multicellularity. Although the basement 22 membrane (BM) is located at tissue interfaces, its mode of action in inter-tissue 23 interactions remains poorly understood, mainly because the molecular and structural 24 details of the BM at distinct inter-tissue interfaces remain unclear. By combining 25 quantitative transcriptomics and immunohistochemistry, we systematically identify the 26 cellular origin, molecular identity and tissue distribution of extracellular matrix molecules 27 in mouse hair follicles, and reveal that BM composition and architecture are exquisitely 28 specialized for distinct inter-tissue interactions, including epidermal-fibroblast, 29 epidermal-muscle and epidermal-nerve interactions. The epidermal-fibroblast interface, 30 namely, hair germ-dermal papilla interface, makes asymmetrically organized side-31 specific heterogeneity in BM, defined by the newly characterized interface, hook and 32 mesh BMs. One component of these BMs, laminin a5, is required for the topological and 33 functional integrity of hair germ-dermal papilla interactions. Our study highlights the 34 significance of BM heterogeneity in distinct inter-tissue interactions. tissues, where it serves to compartmentalize and also tightly integrate tissues 1, 2 . The 40 BM has several crucial roles: i) it provides structural support to cells that is essential for 41 the development of organ structures; ii) it signals to cells through adhesion receptors 42 such as integrins; iii) it controls the tissue distributions and activities of soluble growth 43 factors; and iv) its mechanical characteristics influence cell behavior 3, 4, 5 . Thus, the 44 composition and structure of the BM play critical roles in cell proliferation, 45 differentiation, migration, survival, polarity and positioning, underpinning many 46 fundamental biological phenomena, including the developmental patterning, inter-tissue 47 interactions and stem cell niche formation. 48The BM is composed of a large variety of molecules that exhibit 49 spatiotemporal expression patterns during development and homeostasis, indicating that 50 individual cell types are exposed to tailor-made BM niches 6, 7, 8 . In mammals, the entire 51 set of ECM molecules, called the matrixome or matrisome, is encoded by 52 approximately 300 ECM genes and there are also approximately 800 ECM-associated 53 genes, such as those encoding ECM-modifying enzymes and growth factors 7, 9 54 (http://matrisomeproject.mit.edu/). Although information about the unique distribution, 55 biochemical activities and in vivo functions of individual BM molecules has been 56 accumulated, the entire molecular landscape of the BM composition, including its 57 cellular origins, tissue localizations and pattern-forming processes, in all organs remains 58 largely unknown. One major reason for the difficulty in obtaining a comprehensive 59 Tsutsui et al. 4 understanding of the ECM's composition lies in the biochemical properties of ECM 60 proteins, including their la...

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“…Basement membranes are well‐known structural features of many tissues, providing a substrate for epithelial cell attachment and organization, as well as separating epithelial and mesenchymal tissues . The basement membrane provides a well‐known barrier to epithelial (carcinoma) cell invasion, and a classical feature of malignancy is tumour cell invasion across the basement membrane.…”

Section: Basement Membrane Dynamicsmentioning

confidence: 99%

Extracellular matrix dynamics in cell migration, invasion and tissue morphogenesis

Yamada

Collins

Walma

et al. 2019

Int J Experimental Path

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This review describes how direct visualization of the dynamic interactions of cells with different extracellular matrix microenvironments can provide novel insights into complex biological processes. Recent studies have moved characterization of cell migration and invasion from classical 2D culture systems into 1D and 3D model systems, revealing multiple differences in mechanisms of cell adhesion, migration and signalling-even though cells in 3D can still display prominent focal adhesions.Myosin II restrains cell migration speed in 2D culture but is often essential for effective 3D migration. 3D cell migration modes can switch between lamellipodial, lobopodial and/or amoeboid depending on the local matrix environment. For example, "nuclear piston" migration can be switched off by local proteolysis, and proteolytic invadopodia can be induced by a high density of fibrillar matrix. Particularly, complex remodelling of both extracellular matrix and tissues occurs during morphogenesis. Extracellular matrix supports self-assembly of embryonic tissues, but it must also be locally actively remodelled. For example, surprisingly focal remodelling of the basement membrane occurs during branching morphogenesis-numerous tiny perforations generated by proteolysis and actomyosin contractility produce a microscopically porous, flexible basement membrane meshwork for tissue expansion. Cells extend highly active blebs or protrusions towards the surrounding mesenchyme through these perforations. Concurrently, the entire basement membrane undergoes translocation in a direction opposite to bud expansion. Underlying this slowly moving 2D basement membrane translocation are highly dynamic individual cell movements. We conclude this review by describing a variety of exciting research opportunities for discovering novel insights into cell-matrix interactions. K E Y W O R D S3D culture, basement membrane remodelling, branching morphogenesis, cell migration, extracellular matrix, invasion

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Basement Membranes in Development and Disease

Cited by 171 publications

References 229 publications

Age‐related ultrastructural changes of the basement membrane in the mouse blood‐brain barrier

Age‐related ultrastructural changes of the basement membrane in the mouse blood‐brain barrier

Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions

Extracellular matrix dynamics in cell migration, invasion and tissue morphogenesis

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