Basement Membranes in Neoplasia

Bosman, Fred T.; Havenith, M. G.; Visser, R.; Cleutjens, J. P. M.

doi:10.1016/s0079-6336(11)80212-3

Cited by 21 publications

(19 citation statements)

References 27 publications

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“…Our findings of the immunohistochemical distribution of BMs and intracytoplastic laminin immunoreactivity in transitional cell carcinomas are in accordance with the general observation in other types of tumours (Martinez-Hernandez & Amenta, 1983;Bosman et al, 1985); the more malignant and aggressive the tumour is, the more usual is also the disruption of BMs around the tumour islands and intracytoplasmic laminin immunoreactivity of tumour cells. It has also been shown that BM disruption in bladder carcinomas correlates with lower 5-year survival rate, higher tumour stage, higher histological grade and tumour ploidy (Schapers et al, 1990).…”

Section: Discussionsupporting

confidence: 92%

p53 immunohistochemistry in transitional cell carcinoma and dysplasia of the urinary bladder correlates with disease progression

Soini

Turpeenniemi‐Hujanen²,

Kamel³

et al. 1993

Br J Cancer

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Section: Discussionsupporting

confidence: 92%

p53 immunohistochemistry in transitional cell carcinoma and dysplasia of the urinary bladder correlates with disease progression

Soini

Turpeenniemi‐Hujanen²,

Kamel³

et al. 1993

Br J Cancer

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“…This may relate to the often atypical appearance of carcinoma cells and, furthermore, the innate difficulty in diagnosing carcinoma, which is conclusively defined histologically as breach of the basement membrane. 18 …”

Section: Influence Of Fna On Operative Managementmentioning

confidence: 99%

The diagnostic value of fine needle aspiration in parotid lumps

Mallon

Kostalas

MacPherson

et al. 2013

annals

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North Devon Healthcare NHS Trust, UK 3 Taunton and Somerset NHS Foundation Trust, UK aBSTRacT INTRODUCTION Fine needle aspiration (FNA) is a safe and quick method of diagnosing superficial lumps, which aids preoperative planning. However, FNA of the parotid gland has not gained the widespread acceptance noted in other head and neck lumps. The aim of this study was to determine the ability of FNA of the parotid gland to differentiate benign and malignant disease, and to determine the impact on surgical outcome. METHODS A retrospective analysis of 201 consecutive parotid operations with preoperative FNA in a large district hospital in the UK was performed. The diagnostic characteristics were calculated for benign and malignant disease, and the impact on surgical procedure was determined. RESULTS In identifying benign disease, FNA has a sensitivity of 85% and a specificity of 76%. In detecting malignant disease, FNA has a sensitivity and specificity of 52% and 92% respectively. A false positive on FNA was associated with a higher incidence of neck dissection. CONCLUSIONS FNA is a useful diagnostic test. However, owing to low sensitivity, it is necessary to interpret it in the context of all other clinical information.

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“…A role for u-PA or t-PA in invasion has been postulated because of their involvement in the breakdown of the extracellular matrix, which is essential for carcinoma cells to invade surrounding stroma (Dano et al, 1985;Havenith et al, 1988;Reich et al, 1988;Hendrix et al, 1990;Liotta et al, 1991;Bosman et al, 1992). Indeed, a high level of u-PA production by SW620 cells-in stock culture was found together with invasion into embryonic chick heart fragments.…”

Section: Discussionmentioning

confidence: 99%

In vivo and in vitro invasion in relation to phenotypic characteristics of human colorectal carcinoma cells

Vries

Dinjens²,

Bruyne³

et al. 1995

Br J Cancer

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In vivo and in vitro invasion in relation to (into embryonic chick heart fragments), E-cadherin expression in vivo and in vitro and in vitro production of u-PA and t-PA. These parameters were chosen in view of their purported role in extracellular matrix degradation and intercellular adhesion, which are all involved in the invasive and metastatic cascade. Invasion in vitro was not predictive for invasion or metastasis in vivo. In the cell line which showed invasion in embryonic chick heart tissue, heterogeneous E-cadherin expression was observed in vitro together with a relatively high production of u-PA. The non-invasive cell lines showed in vitro homogeneous expression of E-cadherin with a relatively low production of u-PA. In vivo expression of E-cadherin was either absent or heterogeneous. We conclude that: (1) colorectal carcinoma xenografts show site-specific modification of in vivo invasive and metastatic behaviour; (2) invasion in vitro does not correlate with invasion and metastasis in vivo; (3) in vitro non-invasion might be associated with homogeneous E-cadherin expression and low production of u-PA; (4) E-cadherin expression in vitro differs from E-cadherin expression in vivo. The results support the notion that the microenvironment in which cancer cells grow is one of the factors involved in the regulation of invasive and metastatic behaviour.

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Basement Membranes in Neoplasia

Cited by 21 publications

References 27 publications

p53 immunohistochemistry in transitional cell carcinoma and dysplasia of the urinary bladder correlates with disease progression

p53 immunohistochemistry in transitional cell carcinoma and dysplasia of the urinary bladder correlates with disease progression

The diagnostic value of fine needle aspiration in parotid lumps

In vivo and in vitro invasion in relation to phenotypic characteristics of human colorectal carcinoma cells

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