Basic and clinical aspects of visceral sensation: transmission in the CNS

Bielefeldt, Klaus; Christianson, Julie A.; Davis, Brian M.

doi:10.1111/j.1365-2982.2005.00671.x

Cited by 66 publications

(47 citation statements)

References 119 publications

(155 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Visceral pain is described as pressure-like, intermittently squeezing or cramp, not well localized, vague in character, and difficult for patients to describe [19]. Visceral pain is frequently accompanied by nausea, sweating, defecation, vocalization, grinding, head movement, hyperventilation, hypertension, tachycardia, hypercortisolemia, and hypercatecholaminemia ( Table 1) Gastrointestinal sensory system consist intrinsic (enteric) sensory afferents and extrinsic (vagus, spinal cord, pelvic) afferents.…”

Section: Introductionmentioning

confidence: 99%

Voltage-Gated Calcium Channel Antagonists: Potential Analgesics for Jejunal Pains

Feliks¹,

Wrońska²

2017

Pain Relief - From Analgesics to Alternative Therapies

View full text Add to dashboard Cite

The significant role of voltage-gated calcium channel (VGCC) L-type antagonists used concomitantly with opioids in attenuation of clinical pain has been confirmed. The aim of this study is to evaluate the comparable effect of intracerebroventricularly (i.c.v.) administered diltiazem, nifedipine and/or verapamil -specific antagonists of VGCCsin the dose of 1.0 and 2.0 mg in toto on behavioral signs, clinical symptoms, rumen motor activity and biochemical (plasma cortisol and catecholamine-CA) parameters in sheep that have undergone experimental duodenal distension (DD) and to determine whether voltage-gated calcium channel inhibitors (VGCCIs) exert any anti-nociceptive effects under these conditions. The study was carried out using 24 mature, behind reproductive season crossbred ewes, each weighing 32-42 kg. DD was managed by inclusion and the distension of stretching balloon (having 40 mL of water 39°C temperature-DD40). After 5 min of DD40, the signs were observed: an important augmentation of behavioral nociceptive signs, particularly looking around, defecation, head movement, stretching, grinding, lying down, tachycardia, hyperventilation, inhibition of ruminal contractions (70% approximately, during 15 min) and an increase in plasma catecholamine concentration (over sevenfold increase of epinephrine (E): from 0.24 ± 0.12 in control to 2.98 ± 0.21 mM L −1 during 2 h following DD, 2-times norepinephrine (NE): from 1.29 ± 0.23 in control to 2.51 ± 0.30 mM L −1 and 124% increase of dopamine (DA): from 0.94 ± 0.02 in control to 2.10 ± 0.35 mM L −1 ). VGCCI infusion administered 10 min before duodenal distension diminished severity of jejunal nociceptive reactions, for instance, behavioral symptoms, cardiac acceleration, increase in the number of respiration, inhibition of the reticulum and rumen hypomotility, and effortlessly abolished the increasing presence of plasma cortisol and biogenic amines (CA) release. We suggest that the increase and insistence of visceral hyperalgesia stimulate the flow of Ca 2+ ion flow, provoking neurohormones/neuromediators liberatione and cytoplasmic membrane responsiveness modulation. This result confirmed analgesic effects of VGCCIs L-and/or R-type (nimodipine, lercanidipine, SNX-482) obtained by other authors and also suggests that these channels play a crucial role in the modulation of acute visceral hyperalgesia in sheep and may be a therapeutic target for new drugs.

show abstract

Section: Introductionmentioning

confidence: 99%

Voltage-Gated Calcium Channel Antagonists: Potential Analgesics for Jejunal Pains

Feliks¹,

Wrońska²

2017

Pain Relief - From Analgesics to Alternative Therapies

View full text Add to dashboard Cite

show abstract

“…Peripheral visceral receptors and biochemical mediators are different from somatic nociceptors (Bueno et al, 1997). The central components of the visceral pain pathway are also extremely complex, with both vagal and spinal afferents projecting to forebrain structures such as the insular and anterior cingulate cortex in a multiple synaptic pathway (Bielefeldt et al, 2005). Evidence that electrically generated CEPs also have a longer latency than SEPs confirms that these latency differences cannot be attributed solely to differences in method of stimulation (Hobson et al, 2000b).…”

Section: Discussionmentioning

confidence: 96%

“…The latencies of the component peaks of the CEP recorded from the left and right cortices were not significantly different from each other. The anterior duodenum is innervated by two distinct sets of primary afferent fibers (Al-Chaer and Traub, 2002), both of which are considered to be important in the processing of noxious stimuli (Bielefeldt et al, 2005). Vagal afferents originating in the nodose ganglia project centrally to the nucleus of the solitary tract and spinal afferent fibers in splanchnic nerves project to the thoracic segments (T5-T11) of the spinal cord (Ness and Gebhart, 1990).…”

Section: Discussionmentioning

confidence: 99%

Is it possible to generate cerebral evoked potentials with a mechanical stimulus from the duodenum in rats?

Murrell

Mitchinson

Johnstone

et al. 2007

Journal of Neuroscience Methods

View full text Add to dashboard Cite

“…[18][19] This sensitization most likely reflects convergence of afferent information from the gut and somatic system within the spinal cord (heterosynaptic facilitation). [20] Thus, the peritoneum and the deep muscular layer play a crucial role in the pain induced by abdominal incisions. This assumption is further supported by the failure of epidural analgesia when metameric level is not high enough to block peritoneal nociceptive influx, even after lower abdominal surgery.…”

Section: Discussionmentioning

confidence: 99%

Preperitoneal Blockade in the Treatment of Patients with Perforated Gastroduodenal Ulcers and Peritonitis

Чарышкин¹,

Yakovlev²,

Демин³

2016

Int J Biomed

View full text Add to dashboard Cite

The objective of this study was to improve the results of surgical treatment for patients with perforated gastroduodenal ulcers and peritonitis (PGDU-P) by applying the preperitoneal blockade. Materials and Methods:The study included 102 patients with perforated gastroduodenal ulcers (PGDU) complicated by peritonitis. Patients between 18 and 30 years were predominant. Pain was measured using the Visual Analog Scale (VAS) for Pain. The measurements of intra-abdominal pressure (IAP) by indirect infravesical tensometry were performed daily from the first day after the operation. Surgical interventions (laparotomy, laparoscopic suturing of PGDU, sanitation and drainage of the abdominal cavity) was performed under endotracheal anesthesia in all patients.Patients were divided into two groups depending on the method of postoperative analgesia. Patients of Group 1 (n=62) were subjected only to systemic opioid analgesia (an intramuscular injection of 1% solution of Promedol 1ml 4 times a day). Patients of Group 2 were subjected to systemic opioid analgesia and catheterization of the preperitoneal space for infusion of 0.5% solution of Novocaine in the postoperative period.Results: Postoperative analgesia using preperitoneal blockade after laparotomy and suturing of perforated gastroduodenal ulcers reduced the pain intensity by 2 times in comparison with conventional analgesia. The preperitoneal blockade after laparotomy in PGDU-P patients promotes the effective reduction of intra-abdominal hypertension (IAH) for 2 days. The comparative evaluation of the incidence of the early postoperative complications showed that using preperitoneal blockade contributed to significantly reducing the complications in Group 2. Postoperative mortality was 1.6% in Group 1 and 0 in Group 2. The average length of stay was reduced by approximately 3 days in Group 2 compared to traditional anesthesia. (Int J Biomed. 2016;6(2):114-118.).

show abstract

Basic and clinical aspects of visceral sensation: transmission in the CNS

Cited by 66 publications

References 119 publications

Voltage-Gated Calcium Channel Antagonists: Potential Analgesics for Jejunal Pains

Voltage-Gated Calcium Channel Antagonists: Potential Analgesics for Jejunal Pains

Is it possible to generate cerebral evoked potentials with a mechanical stimulus from the duodenum in rats?

Preperitoneal Blockade in the Treatment of Patients with Perforated Gastroduodenal Ulcers and Peritonitis

Contact Info

Product

Resources

About