Basic and Clinical Pharmacology of Autonomic Drugs

Becker, Daniel E.

doi:10.2344/0003-3006-59.4.159

Cited by 48 publications

(24 citation statements)

References 19 publications

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“…Adrenergic receptors (ARs) including β 1 , β 2 , α 1B , α 2A , α 2B , and α 2C , have been detected in osteoblast lineage cells, and β 2 , α 2A , α 2B , and α 2C are expressed in osteoclast lineage cells . There is an abundance of pharmacological agents targeting ARs owing to their therapeutic value against life‐threatening conditions such as hypertension, asthma, and cardiac arrest . Thus, these drugs have been exploited to great lengths for mechanistic studies into noradrenergic influence on bone and the potential for their use to improve bone mass, and are thoroughly reviewed elsewhere .…”

Section: Molecular Signals From Neurons To Bone—neurotransmittersmentioning

confidence: 99%

“…(111) There is an abundance of pharmacological agents targeting ARs owing to their therapeutic value against life-threatening conditions such as hypertension, asthma, and cardiac arrest. (115) Thus, these drugs have been exploited to great lengths for mechanistic studies into noradrenergic influence on bone and the potential for their use to improve bone mass, and are thoroughly reviewed elsewhere. (116) The effects of sympathetic signaling through NE have been extensively studied following the discovery of the central leptin-sympathetic outflowbone axis (reviewed in Elefteriou and colleagues (117) ).…”

Section: Molecular Signals From Neurons To Bone-neurotransmittersmentioning

confidence: 99%

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Nerves in Bone: Evolving Concepts in Pain and Anabolism

Brazill

Beeve

Craft

et al. 2019

J of Bone & Mineral Res

140

150

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The innervation of bone has been described for centuries, and our understanding of its function has rapidly evolved over the past several decades to encompass roles of subtype‐specific neurons in skeletal homeostasis. Current research has been largely focused on the distribution and function of specific neuronal populations within bone, as well as their cellular and molecular relationships with target cells in the bone microenvironment. This review provides a historical perspective of the field of skeletal neurobiology that highlights the diverse yet interconnected nature of nerves and skeletal health, particularly in the context of bone anabolism and pain. We explore what is known regarding the neuronal subtypes found in the skeleton, their distribution within bone compartments, and their central projection pathways. This neuroskeletal map then serves as a foundation for a comprehensive discussion of the neural control of skeletal development, homeostasis, repair, and bone pain. Active synthesis of this research recently led to the first biotherapeutic success story in the field. Specifically, the ongoing clinical trials of anti‐nerve growth factor therapeutics have been optimized to titrated doses that effectively alleviate pain while maintaining bone and joint health. Continued collaborations between neuroscientists and bone biologists are needed to build on this progress, leading to a more complete understanding of neural regulation of the skeleton and development of novel therapeutics. © 2019 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals, Inc.

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Section: Molecular Signals From Neurons To Bone—neurotransmittersmentioning

confidence: 99%

Section: Molecular Signals From Neurons To Bone-neurotransmittersmentioning

confidence: 99%

Nerves in Bone: Evolving Concepts in Pain and Anabolism

Brazill

Beeve

Craft

et al. 2019

J of Bone & Mineral Res

140

150

View full text Add to dashboard Cite

show abstract

“…Диагностированный нами положительный клинический эффект после употребления м-холинолитика при ИАГ указывает на стимуляцию когнитивных функций, которая обусловлена, как мы предполагаем, увеличением мозгового кровотока, который отмечается под влиянием уменьшением парасимпатической активности, уменьшением нитритивного стресса и активацией симпатоадреналовой системы [10]. Увеличение сократительной функции сердца и ускорение скорости церебрального кровотока является характерной фармакологической реакцией сердечно-сосудистой системы на использование м-холинолитиков [11].…”

Section: Discussionunclassified

Positive Clinical Effects of an M-Cholinolytic in Idiopathic Arterial Hypotension

Baev¹,

Агафонова²

2018

Russ J Cardiol

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Цель. Изучить влияние м-холинолитика на кровообращение, умственные работоспособность и утомляемость, самочувствие у молодых женщин с идиопатической артериальной гипотензией. Материал и методы. Объект исследования-20 женщин с ИАГ (CАД 98 мм рт.ст. и менее) в возрасте от 19 до 32 лет. Предмет исследования-параметры кровообращения (САД, ДАД, ЧСС), умственная трудоспособность и утомляемость по методу E. Kraepelin, оценка самочувствия. В качестве экспериментального препарата применяли однократный контролируемый прием 1 таблетки. Результаты. Через 1 ч после однократного приема препарата выявлено повышение САД с 94 (92-96) мм рт.ст. до 108 (106-112) мм рт.ст., а также ДАД и ЧСС (при р<0,05); увеличение выполненных сложений на 26% (р<0,01); улучшение субъективного самочувствия-у 45% женщин. Через 24 ч на улучшение субъективного самочувствия указали 85%. Заключение. При идиопатической артериальной гипотонии у молодых женщин однократный прием м-холинолитика имеет следующие положительные эффекты: повышение САД, ДАД и умственной работоспособности (через 1 ч) и улучшение самочувствия (через 1 ч и через 24 ч).

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“…The doses and cardiovascular influences of both epinephrine and levonordefrin have been thoroughly reviewed in previous continuing education articles in this journal. 16,17 Epinephrine is the vasoconstrictor used most commonly, and produces the systemic cardiovascular effects illustrated in Figure 2. Even small doses of epinephrine produce these cardiovascular effects; this is unequivocal.…”

Section: Vasoconstrictors: Epinephrine and Levonordefrinmentioning

confidence: 99%

Adverse Drug Reactions in Dental Practice

Becker

2014

Anesthesia Progress

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Adverse reactions may occur with any of the medications prescribed or administered in dental practice. Most of these reactions are somewhat predictable based on the pharmacodynamic properties of the drug. Others, such as allergic and pseudoallergic reactions, are less common and unrelated to normal drug action. This article will review the most common adverse reactions that are unrelated to drug allergy.

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Basic and Clinical Pharmacology of Autonomic Drugs

Cited by 48 publications

References 19 publications

Nerves in Bone: Evolving Concepts in Pain and Anabolism

Nerves in Bone: Evolving Concepts in Pain and Anabolism

Positive Clinical Effects of an M-Cholinolytic in Idiopathic Arterial Hypotension

Adverse Drug Reactions in Dental Practice

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