Basic and Meal Stimulated Plasma GIP Levels are Higher in Lean PCOS Women with FAI over 5

Milewicz, Tomasz; Migacz, Kamila; Кялка, Марта; Rogatko, Iwona; Kowalczuk, Aleksandra; Spałkowska, Magdalena; Mrozińska, Sandra; Z, Czajkowska; Sztefko, Krystyna

doi:10.1055/s-0042-101165

Cited by 4 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Milewicz et al . [ 40 ] studied the relationship between the free androgen index and basal as well as the meal-stimulated level of glucose-dependent insulinotropic peptide (GIP) in lean women affected by PCOS. They found that excess androgen activity might be a factor contributing to alteration in the secretion of incretins in lean women affected by PCOS.…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

Debates regarding lean patients with polycystic ovary syndrome: A narrative review

Goyal

Dawood

2017

J Hum Reprod Sci

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is a complex syndrome showing the clinical features of an endocrine/metabolic disorder, including hyperinsulinemia and hyperandrogenism. Two phenotypes are present, either lean or obese, with different biochemical, hormonal, and metabolic profiles. Evidence suggests many treatment modalities that can be applied. However, many of these modalities were found to be not suitable for the lean phenotype of PCOS. Much contradictory research was found regarding lean patients with PCOS. The aim of this narrative review is to shed light on the debate prevailing regarding characteristics, as well as metabolic, hematological, and potential management modalities. Literature review was performed from January 1, 2000 to March 31, 2017 with specific word search such as lean PCOS, hormonal abnormalities in lean PCOS, and the management of lean PCOS. All retrieved articles were carefully assessed, and data were obtained. We could conclude that the debate is still prevailing regarding this specific lean population with PCOS, especially with regard to their characteristics and management modalities. Further studies are still required to resolve this debate on the presence of PCOS in lean women.

show abstract

Section: Aterials and M Ethodsmentioning

confidence: 99%

Debates regarding lean patients with polycystic ovary syndrome: A narrative review

Goyal

Dawood

2017

J Hum Reprod Sci

View full text Add to dashboard Cite

show abstract

Incretins modulate progesterone biosynthesis by regulating bone morphogenetic protein activity in rat granulosa cells

Nishiyama

Hasegawa

Fujita

et al. 2018

The Journal of Steroid Biochemistry and Molecular Biology

View full text Add to dashboard Cite

The effects of incretins on ovarian steroidogenesis have not been clarified. In this study, we investigated the effects of incretins, including GIP and GLP-1, on ovarian steroidogenesis using rat primary granulosa cells. Treatment with incretins significantly suppressed progesterone synthesis in the presence of FSH, and the effect of GIP was more potent than that of GLP-1. In contrast, incretins had no significant effect on estrogen synthesis by rat granulosa cells. In accordance with the effects of incretins on steroidogenesis, GIP and GLP-1 suppressed the expression of progesterogenic factors and enzymes, including StAR, P450scc, 3βHSD, but not P450arom, and cellular cAMP synthesis induced by FSH. In addition, incretins moderately increased FSHR mRNA expression in granulosa cells. Of note, treatment with GIP, but not treatment with GLP-1, augmented Smad1/5/8 phosphorylation and transcription of the BMP target gene Id-1 induced by BMP-6 stimulation, suggesting that GIP upregulates BMP receptor signaling that can inhibit FSH-induced progesterone synthesis in rat granulosa cells. On the other hand, BMP-6 treatment suppressed the expression of GIP receptor but not that of GLP-1 receptor. Expression of the BMP type-I receptor ALK-3 was upregulated by treatment with GIP and GLP-1 and that of ALK-6 was also increased by GIP, while inhibitory Smad6 expression was impaired by GIP and GLP-1 in rat granulosa cells. Collectively, the results indicate that incretins, particularly GIP, impair FSH-induced progesterone production, at least in part, by upregulating BMP signaling in rat granulosa cells. The modulatory effects of incretins on endogenous BMP activity may be applicable to treatment of dysregulated steroidogenesis such as polycystic ovary syndrome.

show abstract

RETRACTED: Whey protein preload enhances the active GLP-1 response and reduces circulating glucose in women with polycystic ovarian syndrome

et al. 2021

View full text Add to dashboard Cite

Basic and Meal Stimulated Plasma GIP Levels are Higher in Lean PCOS Women with FAI over 5

Cited by 4 publications

References 23 publications

Debates regarding lean patients with polycystic ovary syndrome: A narrative review

Debates regarding lean patients with polycystic ovary syndrome: A narrative review

Incretins modulate progesterone biosynthesis by regulating bone morphogenetic protein activity in rat granulosa cells

RETRACTED: Whey protein preload enhances the active GLP-1 response and reduces circulating glucose in women with polycystic ovarian syndrome

Contact Info

Product

Resources

About