Basic aqueous chemistry of [M(OH2)3(CO)3]+ (M=Re, Tc) directed towards radiopharmaceutical application

Ligand exchange and complex formation kinetics studied by NMR exemplified on fac-[(CO)3M(H2O)]+ (M=Mn, Tc, Re)

“…An important isotope for radioactive imaging agents is 99m Tc and there is a strong interest in the development of new labelling techniques using this short-lived isotope. The use of the water-soluble tricarbonyl trihydrate technetium(I) cation, fac-[(CO) 3 Tc(H 2 O) 3 ] + , as building block has allowed to synthesize a series of new, promising compounds [20][21][22][23][24]. Because the majority of compounds that have been labelled with 99m Tc can also be labelled with 186 Re or 188 Re these complexes form couples that can be used for diagnosis (Tc) and therapy (Re) [20].…”

“…The use of the water-soluble tricarbonyl trihydrate technetium(I) cation, fac-[(CO) 3 Tc(H 2 O) 3 ] + , as building block has allowed to synthesize a series of new, promising compounds [20][21][22][23][24]. Because the majority of compounds that have been labelled with 99m Tc can also be labelled with 186 Re or 188 Re these complexes form couples that can be used for diagnosis (Tc) and therapy (Re) [20]. The three isotopes mentioned can be obtained from generator systems and have a half-life ranging from 6 h ( 99m Tc) to 69 d ( 186 Re) (Table 1) [25,26].…”

“…From this precursor a complex has to be formed which has no structural or metalbased reactivity. Since its first synthesis fac-[(CO) 3 Tc(H 2 O)] + [28] became one of these precursors and a large number of substitution products have now been synthesized and structurally characterized [20,[29][30][31][32][33][34]. Understanding reactivity and mechanisms of substitution of the three labile water molecules became an important issue especially in the context of synthesis of similar technetium and rhenium complexes.…”

Crystal structure of hexacarbonyl bis(μ2-2-methoxybenzenethiolato-κ2 S)pyridine(triphenylphosphane)dirhenium(I), C43H34NO8PS2Re2

“…It also has the potential of exchanging speci cally the labile solvent ligands (i.e. water) to allow for the coordination of multidentate ligand systems [8,9]. This contribution forms part of a longterm study to investigate di erent aspects of middle and late transition metal centers when coordinated to O, N and S donor ligands [10][11][12][13][14][15][16][17][18][19].…”

Crystal structure of fac-tricarbonyl-2-((E)-(3-amino-2-hydroxypropylimino) methyl)phenol rhenium(I) toluene solvate, C33H34N4O10Re2

“…In continuation of our interest in rhenium-based coordination compounds that might serve as radiopharmaceuticals,arhenium(I) starting materialw as reacted with at wofold Schiff-base derived from salicylaldehyde and 1,3-diaminopropan-2-ol. The structural analysis of the compound showed the formation of amononu-clear rhenium(I) coordination compound withamodified ligand system.S imilar compounds featuring acomparable set of donor atomshave been reported in the literature already [3][4][5].The octahedral coordination sphere around the central atom is created by three carbonyl ligands in fac configuration as well as apartially hydrolyzed derivative of the initially two-fold Schiff-base ligand acting as an O,N,N' donor. In addition, half amolecule of toluene is present in the crystal structure of the title compound.…”