Basic Biological Sciences

Abstract

It has been shown in laboratory and animal studies that tooth enamel becomes considerably more reactive toward low levels of fluoride after receiving pre-treatment which forms dicalcium phosphate dihydrate (DCPD) in the enamel as an intermediate. This in vitro study was undertaken to determine the effect on human enamel fluoride uptake of incorporating DCPD-forming rinses into a conventional fluoride rinsing program. In one group, enamel samples received a one-minute rinse with 0.2% NaF each day for 20 days. Samples in the second group were treated identically, except that they were also given a one-minute DCPD-forming rinse prior to the first, sixth, eleventh, and sixteenth fluoride rinses. At the end of the rinsing program, all samples were washed in 1 M KOH to remove labile fluorides. The enamel biopsy data showed that the fluoride uptake resulting from 0.2% NaF alone was not statistically significant, whereas uptake produced by the DCPD-forming plus NaF rinses was significant. The results suggest that the DCPD-forming rinse may improve the efficacy of fluoride rinse programs.

CPP–ACP and Fluoride: A Synergism to Combat Caries

“…24 Also, the addition of calcium and phosphate to fluoride formulations in the form of CPP–ACP can enhance fluoride uptake by enamel. 25,26…”

In VitroEffects of Two Topical Varnish Materials and Er:YAG Laser Irradiation on Enamel Demineralization around Orthodontic Brackets

“…There is an increasing level of research focusing on how calcium and phosphate supplementation of fluoride treatment can enhance fluoride uptake [21, 22]. Today, there are many compounds of calcium phosphate with different calcium and phosphate ion availabilities [7].…”