This paper presents a novel study of evaluating non-ionizing effect of 2.45 GHz Wireless Body Area Networks (WBAN) radiofrequency (RF) electromagnetic fields (EMF) exposure on human physiological parameters and cognitive performance. The study aims to test the hypothesis whether exposure of 2.45 GHz WBAN radio electromagnetic fields may affect physiological parameters and cognitive performance of human. Twenty healthy volunteers are involved in the test and exposed to 2.45 GHz WBAN RF radiation, emitted by a planar textile monopole antenna. Physiological measures of body temperature, systolic blood pressure, diastolic blood pressure and heart rate are obtained, along with cognitive performance outcomes. Results indicated that no significant difference is observed in any of the three sessions (pre, exposure and post) for all physiological parameters, p > 0.05. Insufficient evident is found to indicate a difference in mean of all cognitive tests between WBAN RF and Sham exposure sessions, p's > 0.05.