Basic Coagulation Parameters among Human Immunodeficiency Virus-Infected Adults in Gondar, Northwest Ethiopia: A Comparative Cross-Sectional Study

Seyoum, Masresha; Enawgaw, Bamlaku; Getaneh, Zegeye; Engidaye, Getabalew; Asrie, Fikir; Melku, Mulugeta

doi:10.1155/2018/5320827

Cited by 9 publications

(14 citation statements)

References 35 publications

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“…Due to haematological, hemorrhagic, and thrombotic clinical changes caused by HIV infection, coagulation tests such as PT / INR and aPTT are often considered as global hemostatic markers. A reduction in clotting time in these tests has been associated with hypercoagulability.PT, APTT, and INR were significantly higher, whereas platelet count was significantly lower in HIV-infected adults (both who were taking HAART and HAART-naïve) than HIVseronegative adults (P<0.001) [58]. We do not know in the medical literature references about the normal range in the elderly or if the values are different from the general population.The exception is when they have vascular diseases such as hypertension and diabetes, use of heart prostheses, hepato-intestinal diseases.…”

Section: Discussionmentioning

confidence: 73%

Hemostasis in elderly patients with human immunodeficiency virus (HIV) infection—Cross-sectional study

et al. 2020

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Introduction: Aging and chronic HIV infection are clinical conditions that share the states of inflammation and hypercoagulability. The life expectancy of the world population has increased in the last decades, bringing as complications the occurrence of diseases that undergoing metabolic, bone, cardiological, vascular and neurological alterations. HIVinfected patients experience these changes early and are living longer due to the success of antiretroviral therapy. The objectives of this study was to evaluate some changes in the plasma hemostatic profile of 115 HIV-reactive elderly individuals over 60 years old in the chronic phase of infection, and compare with 88 healthy uninfected elderly individuals. Plasma determinations of D-dimers, Fibrinogen, von Willebrand Factor, Antithrombin, Prothrombin Time, Activated Partial Thromboplastin Time, and platelet count were performed. In the HIV-reactive group, these variables were analyzed according to viral load, protease inhibitor use and CD4 + T lymphocyte values. After adjusted values for age and sex, the results showed higher levels of Antithrombin (103%; 88%, p = 0.0001) and Prothrombin Time activities (92.4%; 88.2%, p = 0.019) in the HIV group compared to the control group. We observed higher values of Fibrinogen in protease inhibitor users in both the male (p = 0.043) and female (p = 0.004) groups, and in the female HIV group with detected viral load (p = 0.015). The male HIV group with a CD4 + count> 400 cells / mm 3 presented higher von Willebrand Factor values (p = 0.036). D-Dimers had higher values in the older age groups (p = 0.003; p = 0.042, respectively). Conclusion: Our results suggest that the elderly with chronic HIV infection with few comorbidities had a better hemostatic profile than negative control group, reflecting the success of treatment. Protease inhibitor use and age punctually altered this profile.

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Section: Discussionmentioning

confidence: 73%

Hemostasis in elderly patients with human immunodeficiency virus (HIV) infection—Cross-sectional study

et al. 2020

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“…A previous study reported that the contact activation coagulation pathway in PLWH was overactive despite cART and immune reconstitution 22 . In contrast, two studies conducted in African settings found prolonged APTT in PLWH compared to uninfected controls 13 , 20 . These findings may be explained by inclusion of PLWH with late stage disease and consumption of coagulation factors due to endothelial dysfunction or impaired liver synthesis in the latter studies 13 , 26 , 27 .…”

Section: Discussionmentioning

confidence: 79%

“…In contrast, two studies conducted in African settings found prolonged APTT in PLWH compared to uninfected controls 13 , 20 . These findings may be explained by inclusion of PLWH with late stage disease and consumption of coagulation factors due to endothelial dysfunction or impaired liver synthesis in the latter studies 13 , 26 , 27 . In studies including both treated PLWH and uninfected controls, findings have been inconsistent with regard to possible associations between HIV and APTT 13 , 20 , 22 .…”

Section: Discussionmentioning

confidence: 79%

“…Prothrombin time (PT), the unstandardized equivalent to INR, that reflects concentrations of coagulation factor II–VII–X has been reported to be both prolonged and short in cART treated PLWH compared to controls 10 , 20 , 21 . Furthermore, APTT has been reported to be shorter, prolonged and normal in treated PLWH compared to controls 9 , 11 , 13 , 22 .…”

Section: Introductionmentioning

confidence: 98%

“…In recent guidelines, early initiation of combination antiretroviral therapy (cART) in all PLWH is recommended 8 . Most prior studies of coagulation in treated PLWH have been small or conducted in populations with both untreated and treated participants 9 – 13 , and no clear consensus regarding whether or not initiation of cART results in normalization of the coagulation system has been reached 14 – 19 .…”

Section: Introductionmentioning

confidence: 99%

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Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication

Fink

Knudsen

Thudium

et al. 2021

Sci Rep

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Altered coagulation has been reported in people living with HIV (PLWH) with ongoing viral replication and may predispose to cardiovascular diseases. However, less is known about coagulation in PLWH with undetectable viral replication. In a cross-sectional observational study, we investigated whether HIV infection with undetectable viral replication is independently associated with activated partial thromboplastin time (APTT) and coagulation factor II–VII–X concentrations out of reference. Logistic regression analyses were used to assess the association of HIV infection with APTT and coagulation factor II–VII–X, after adjusting for age, sex, smoking status, alcohol consumption, BMI, diabetes and hsCRP. 936 PLWH with undetectable viral replication from the Copenhagen Co-morbidity in HIV infection study (COCOMO-study) and 2955 uninfected controls were included. Higher prevalence of short APTT was found in PLWH compared to controls (13.5% vs. 7.6%, P < 0.001). Furthermore, higher prevalence of low coagulation factor II–VII–X was found in PLWH than in controls (9.6% vs. 7.4%, P = 0.022). HIV was independently associated with short APTT (adjusted odds ratio (aOR) 2.3 (95% CI 1.7–2.9), P < 0.001) and low coagulation factor II–VII–X (aOR 1.4 (95% CI 1.0–1.9), P = 0.046). Few participants among PLWH and controls had both short APTT and low coagulation factor II–VII–X, 2.1% vs. 0.8%, respectively. We found evidence of both procoagulant (short APTT) and anticoagulant (low coagulation factor II–VII–X) alterations in PLWH with undetectable viral replication, and our findings suggest that two different coagulation phenotypes exist in participants with treated HIV infection.

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Plasma levels of fibrinolytic and coagulation biomarkers in HIV‐infected individuals on highly active antiretroviral therapy: A case‐control study in a Northern Ghanaian population

Derigubah

Nkansah

Mensah

et al. 2023

Health Science Reports

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Background and Aim: Impaired coagulation and fibrinolysis have been implicated in thromboembolism in human immunodeficiency virus (HIV)-infected individuals. This study evaluated the plasma levels of plasminogen activator inhibitor-1 (PAI-1) and coagulation biomarkers in HIV-infected individuals on highly active antiretroviral therapy (HAART).Methods: This matched case-control study from March to December, 2020 comprised 76 participants: 38 HIV-positive individuals on HAART and 38 apparently healthy HIV-negative individuals as controls. Blood samples were collected for prothrombin time (PT), activated partial thromboplastin time (aPTT), D-dimers, PAI-1, and soluble fibrin monomer complex (SFMC) estimations. The data were analysed using SPSS version 22.0 and statistical significance was set at p < 0.05.

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Basic Coagulation Parameters among Human Immunodeficiency Virus-Infected Adults in Gondar, Northwest Ethiopia: A Comparative Cross-Sectional Study

Cited by 9 publications

References 35 publications

Hemostasis in elderly patients with human immunodeficiency virus (HIV) infection—Cross-sectional study

Hemostasis in elderly patients with human immunodeficiency virus (HIV) infection—Cross-sectional study

Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication

Plasma levels of fibrinolytic and coagulation biomarkers in HIV‐infected individuals on highly active antiretroviral therapy: A case‐control study in a Northern Ghanaian population

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