Basic Coagulation Profiles and Platelet Parameters Among Adult Type 1 and Type 2 Diabetes Patients at Dessie Referral Hospital, Northeast Ethiopia: Comparative Cross-Sectional Study

Ebrahim, Hussen; Asrie, Fikir; Getaneh, Zegeye

doi:10.2147/jbm.s287136

Cited by 6 publications

(9 citation statements)

References 37 publications

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“…The prevalence of prolonged PT is lower compared to Ebrahim et al study in Ethiopia that reported a 16.7% prevalence of prolonged PT among T2DM patients. 44 Nevertheless, the prevalence of prolonged aPTT is higher compared to Ebrahim’s study that reported a 1.7% prevalence. The possible reason might be due to differences in sample size, reference range used, and the study design.…”

Section: Discussionmentioning

confidence: 72%

“… 54 In this study, the prevalence of thrombocytopenia is in line with Ebrahim et al study in Ethiopia that reported a 5% prevalence. 44 In addition to this, studies that are conducted in different parts of the world supported the presence of thrombocytopenia among T2DM patients. A comparative cross-sectional study conducted by Pan et al in China, 48 Madan et al in India, 55 and Asrat et al in Ethiopia 40 showed that T2DM patients were presented with thrombocytopenia.…”

Section: Discussionmentioning

confidence: 86%

“… 7 , 8 , 41–43 The prevalence of shortened PT and aPTT in this study is lower compared to a study conducted by Ebrahim et al in Ethiopia that reported a 16.7% and 63.3% prevalence of shortened PT and aPTT, respectively. 44 The possible reason for this difference might be due to variation in study design, sample size, and the reference range used for the CBC and coagulation tests. A comparative cross-sectional study conducted in a different part of the world also revealed that there is a shortening of PT and aPTT values among T2DM patients.…”

Section: Discussionmentioning

confidence: 99%

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The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Getu¹,

Aynalem²,

Bizuneh³

et al. 2022

DMSO

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Introduction Diabetes mellitus is a heterogeneous disorder of metabolism which results hyperglycemic-related atherothrombotic complications. These complications are the leading cause of death in diabetes mellitus patients. Therefore, this study was aimed to determine the prevalence of coagulopathy and associated factors among adult type II diabetes mellitus patients attending at University of Gondar comprehensive specialized hospital. Methods A facility-based cross-sectional study was conducted among 357 study participants. A questionnaire and a data collection sheet were used to collect the sociodemographic and clinical data, respectively. About 6mL of venous blood samples were collected for coagulation tests and complete blood count. For prolonged coagulation tests, a mixing test was performed. Data were entered into EpiInfo and exported to SPSS for statistical analysis. Then, descriptive statistics were done. A binary and multivariable logistic regression model was used to identify the associated factors. P-value <0.05 was considered as statistically significant. Results In this study, 357 study participants were included. Of them, 52.1% (186) and 80.7% (288) were females and urban residences, respectively. The prevalence of coagulopathy was 26.6% (95% CI: 22.1, 31.5%). Out of this, 12.3% and 8.7% showed shortened PT and aPTT, respectively. In addition, the prevalence of prolonged PT and aPTT were 5.6% and 3.9%, respectively. From the prolonged PT and aPTT, the prevalence of factor deficiency was 95% and 92.8%, respectively. Being female (AOR = 2.06; 95% CI: 1.11–3.85%), abnormal BMI (AOR = 1.94; 95% CI: 1.08–3.50), and educational status of high school (AOR = 0.26; 95% CI: 0.10–0.83%) were significantly associated with hypercoagulation. Conclusion Coagulopathy is an important public health problem among type II diabetes mellitus patients. Being female and having abnormal BMI were associated with hypercoagulation. Therefore, regular monitoring of coagulation parameters is vital to reduce the consequence of coagulopathy.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Getu¹,

Aynalem²,

Bizuneh³

et al. 2022

DMSO

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“…IR can alter and upregulate gene expression pathways involving coagulation proteins, which can cause increased production of coagulation factors (including FIB, FVII, FVIII, FXII, FXIII) and fibrinogen activator inhibitor type 1 (PAI-1), resulting in a pro-thrombotic state. 23 In addition, the patients with insulin resistance have more visceral fat. 24 Visceral fat has been found to be associated with increased activity of FVII, FVIII, and FIX.…”

Section: Discussionmentioning

confidence: 99%

The Correlation Between Estimated Glucose Disposal Rate and Coagulation Indexes in Type 2 Diabetes Mellitus

Li¹,

Qi²,

Jia³

et al. 2022

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Purpose To study the correlation between estimated glucose disposition rate (eGDR) and coagulation parameters in type 2 diabetes patients (T2DM). Materials and Methods A total of 948 patients suffering from T2DM were enrolled for this research. Various blood coagulation parameters including prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen (FIB) were assessed. Body mass index (BMI), hypertension, and the levels of glycated hemoglobin (HbA1c) were used to calculate the patients’ eGDRs. All patients were sorted into two groups: those with high eGDRs (eGDR≥7.5) and those with low eGDRs (eGDR<7.5). The patients were then separated into groups of men and women. The connection between eGDR and coagulation indexes was examined using Spearman correlation, Pearson correlation, and multiple linear regression analysis. Results In comparison to the high-eGDR group, reduced PT and APTT levels with increased FIB levels were observed in the low-eGDR group ( P =0.006, P <0.001, and P = 0.035, respectively). The eGDR showed a positive relation with APTT (r = 0.142, P < 0.001), a negative relation with FIB (r = −0.082, P = 0.012), and no correlation with PT (r =0.064, P =0.050) in the all patients. As well as, the eGDR demonstrated a positive relation with APTT (r = 0.173, P < 0.001), a negative relation with FIB (r = −0.093, P = 0.03), and no relation with PT (r = 0.045, P = 0.300) in the male subgroups. Additionally, this correlation persisted following the adjustment of other factors in multilinear regression analysis. However, the female subgroup demonstrated no correlation among eGDR and PT, APTT or FIB (r = 0.086, P = 0.083, r = 0.097, P = 0.05;r = −0.058, P = 0.240, respectively). Conclusion Our study is the first to prove that eGDR demonstrates a correlation with coagulation indexes in T2DM patients. And, this correlation is gender-specific.

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“…The methods of Hussen Ebrahim et al were used to analyze the coagulation and platelet parameters [ 26 ]. Platelet parameters (platelet count, mean platelet volume (MPV), and platelet distribution width (PDW)) were analyzed using a Dirui BF 6500 automated hematology analyzer (Dirui, China) within 2 hours of sample collection.…”

Section: Methodsmentioning

confidence: 99%

A Comparative Cross-Sectional Study of Coagulation Profiles and Platelet Parameters of Schistosoma mansoni-Infected Adults at Haik Primary Hospital, Northeast Ethiopia

Bisetegn

Feleke

Ebrahim

et al. 2022

Interdisciplinary Perspectives on Infectious Diseases

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Introduction. Schistosoma mansoni is an intravascular parasite that interacts with all components of the host blood. Nearly, 10% of S. mansoni-infected patients progress to severe hepatosplenic Schistosomiasis is characterized by periportal fibrosis, obstruction of intrahepatic veins, presinusoidal portal hypertension, and splenomegaly. Thus, this study aimed to compare the basic coagulation profiles and platelet parameters of S. mansoni-infected adults and noninfected individuals as controls at Haik Primary Hospital, Northeast Ethiopia. Methods. A comparative cross-sectional study was conducted at Haik Primary Hospital from April to June 2021. The diagnosis and intensity of S. mansoni infection was determined using the Kato–Katz technique. The coagulation profiles and platelet parameters were analyzed using coagulation and hematology analyzers. Data were analyzed using SPSS version 26.0. The Kolmogorov–Smirnov and Shapiro–Wilk tests were done to check the distribution of continuous variables. The Mann–Whitney U test was used to compare the coagulation profiles and platelet parameters. Spearman’s rank-order correlation was done to assess the correlation between the intensity of infection and coagulation profiles and platelet parameters. In all comparison, a P value <0.05 was considered statistically significant. Result. In this study, a total of 180 study participants (90 S. mansoni-infected adults and 90 controls) were included. Of the total S. mansoni-infected adults, 55.6%, 28.9%, 33, and 15.6% had light, moderate, and heavy intensity of infections, respectively. All S. mansoni-infected study participants had prolonged prothrombin time (PT) and international normalized ratio (INR). Moreover, about 80% of S. mansoni-infected adults had prolonged activated partial thromboplastin time (APTT). Thrombocytopenia was found in 26.7% of the S. mansoni-infected adults. The Mann–Whitney U test showed a statistically significant difference in coagulation profiles between S. mansoni-infected adults and healthy controls ( P -value ≤0.001). The Kruskal–Wallis H-test showed a significant difference in PT, APTT, and INR between the intensity of infection and healthy controls ( P -value <0.05). Conclusion. This study showed a prolonged coagulation time in S. mansoni-infected individuals. Thus, screening of schistosomiasis patients for hemostatic abnormalities and treating the underlying disorder is crucial.

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Basic Coagulation Profiles and Platelet Parameters Among Adult Type 1 and Type 2 Diabetes Patients at Dessie Referral Hospital, Northeast Ethiopia: Comparative Cross-Sectional Study

Cited by 6 publications

References 37 publications

The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

The Correlation Between Estimated Glucose Disposal Rate and Coagulation Indexes in Type 2 Diabetes Mellitus

A Comparative Cross-Sectional Study of Coagulation Profiles and Platelet Parameters of Schistosoma mansoni-Infected Adults at Haik Primary Hospital, Northeast Ethiopia

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