Basic Concepts and Applications of Porphyrins, Chlorins and Phthalocyanines as Photosensitizers in Photonic Therapies

Oliveira, Kléber T. de; Souza, Juliana Maria de; Gobo, Nicholas Roberto da Silva; Assis, Francisco F. de; Brocksom, Timothy J.

doi:10.5935/1984-6835.20150016

Cited by 15 publications

(16 citation statements)

References 20 publications

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“…Moreover, after secondary treatment, part of the organic matter remains in the WW, leading to eutrophication of receiving waters and allowing bacterial growth. Nevertheless, once the photodynamic action occurs through the generation of ROS, the damages in the bacterial cells could occur (1) via the interaction between the excited PS and O 2 , resulting in 1 O 2 formation, which will interact with the cellular components through oxidative reactions originating their oxidative damage; or (2) via the energy transference from the excited PS to the surrounding substrates [8, 24,40]. Although the occurrence of each type of interaction between PS and the surroundings highly depends on the chemical structure of the PS and according to the literature, porphyrin derivatives PS tend to generate ROS via the energy transference to O 2 , the higher PDI efficiency in the tests using WW as medium suspension shown in our study could be explained by the high presence of organic matter in the medium.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Action against Wastewater Microorganisms and Chemical Pollutants: An Effective Approach with Low Environmental Impact

Bartolomeu

Reis

Fontes

et al. 2017

Water

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Wastewater (WW) from urban and industrial activities is often contaminated with microorganisms and chemical pollutants. To reduce the concentration of microorganisms in WW to levels comparable to those found in natural waters, the sewage effluent is usually subjected to disinfection with chlorine, ozone, or ultraviolet light, which may lead to the formation of toxic products and contribute to the selection of resistant genes. Moreover, the changing patterns of infectious diseases and the emerging of multidrug resistant microbial strains entail the development of new technologies for WW decontamination. Microbial photodynamic inactivation (PDI) with photosensitizers, oxygen, and visible light has demonstrated to be effective in the inactivation of microorganisms via photogeneration of reactive oxygen species able to induce microbial damage at the external structures level. The promising results of PDI suggest that this principle can be applied to WW treatment to inactivate microorganisms but also to photodegrade chemical pollutants. The aim of this study was to assess the applicability of PDI for the microbial and chemical decontamination of secondarily treated WW. To evaluate the efficiency of bacterial inactivation in WW, experiments were done in both phosphate buffer saline (PBS) and filtered WW with the bioluminescent Escherichia coli, using small and large volumes of WW. The potential of PDI to inactivate the native bacteria (E. coli and Enterococcus) present in WW was tested and assays without the adding of bacteria to the WW were performed. It was also tested if the same PDI protocol was able to induce phototransformation of phenol. The cationic porphyrin 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin tetra-iodide (Tetra-Py + -Me) was shown to be effective against both bacterial groups representing both Gram-negative and Gram-positive bacteria used as microbiological parameters to instigate water quality and even showing the power to photooxidate organic compounds. As the photosensitizer when immobilized on solid matrixes can be easily removed, recovered, and reused, an effective, less-expensive, easy-applicable, and environmentally friendly technology can be applied to treat WW, inactivating microorganisms and degrading chemical contaminants at the same time.

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Section: Discussionmentioning

confidence: 99%

Photodynamic Action against Wastewater Microorganisms and Chemical Pollutants: An Effective Approach with Low Environmental Impact

Bartolomeu

Reis

Fontes

et al. 2017

Water

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“…Recently, NPWs have been exploited in porphyrin synthesis (Scheme 8). These dyes are natural or synthetic compounds which present relevant physical and chemical properties and numerous applications as photocatalysts, dyesensitized solar cells, sensors, molecular electronics, non-linear optics and in medicine, especially with regard to photodynamic therapy (PDT) for some cancers treatments (de Oliveira et al 2015, Barona-Castaño et al 2016.…”

Section: Drugs Obtained Under Superheated Processing (High T) and Solmentioning

confidence: 99%

Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients

Souza

Galaverna

Souza

et al. 2018

An. Acad. Bras. Ciênc.

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We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs.

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“…These classes of compounds are not naturally occurring, unlike their analogues porphyrins, chlorins and bacteriochlorins [24,25]. Phthalocyanines were accidentally discovered at the beginning of the last century and only systematically studied in the 1930s by Linstead and Robertson, who finally established their structure and a general synthetic methodology [26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of a Naphthalocyanine-Like Dye: The First Report on Zn(II)-1,6-methano[10]annulenecyanine

2020

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The synthesis of the new dye 1,6-methano[10]annulenecyanine is described. For this purpose, the 3,4-dicyano-1,6-methano[10]annulene and 3,4-carboxyimide-1,6-methano[10]annulene buildings blocks were synthesized in six to eight steps. In both cases, these building blocks were then cyclotetramerized to furnish a new Zn(II)-1,6-methano[10]annulenecyanine which presents a strong red-shifted absorption band at 800 nm and high solubility in common organic solvents.

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Basic Concepts and Applications of Porphyrins, Chlorins and Phthalocyanines as Photosensitizers in Photonic Therapies

Cited by 15 publications

References 20 publications

Photodynamic Action against Wastewater Microorganisms and Chemical Pollutants: An Effective Approach with Low Environmental Impact

Photodynamic Action against Wastewater Microorganisms and Chemical Pollutants: An Effective Approach with Low Environmental Impact

Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients

Synthesis of a Naphthalocyanine-Like Dye: The First Report on Zn(II)-1,6-methano[10]annulenecyanine

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