This paper proposes a loss minimization control method based on improved gradient descent algorithm (GDA) for interior permanent magnet synchronous machine (IPMSM). Since the power of PMSM is derived from the measured phase voltage and current, this method is independent from the iron loss model containing motor parameters. Meanwhile, it can guarantee the stability of PMSM system when entering the searching period. Both maximum torque per ampere (MTPA) and id = 0 control are carried out to validate the effectiveness of the proposed method. The experimental results are demonstrated to verify the proposed approach.