Basic Fibroblast Growth Factor Attenuates Bisphosphonate-Induced Oxidative Injury but Decreases Zinc and Copper Levels in Oral Epithelium of Rat

Abstract

Recent studies have reported oxidative damage due to bisphosphonate (BP) in various cancer tissues and neurons, although basic fibroblast growth factor (bFGF) induced antioxidant effects in the cells. The bFGF may modulate the BP-induced oxidative stress in oral epithelium of rats. This study was undertaken to explore possible beneficial antioxidant effects of bFGF on oxidative stress induced by BP in oral epithelium of rats. Twenty-eight rats were equally divided into four groups. The first group was used as control. The second, third and fourth groups intraperitoneally received BP (zoledronic acid), bFGF and BP + bFGF. At the end of 10 weeks, the rats were sacrificed, and oral epithelium samples were taken for analyses. In BP group, the lipid peroxidation levels were increased in the oral epithelium, while the activities of glutathione peroxidase (GSH-Px) and the concentrations of total antioxidant status (TAS) were decreased. In rats treated with bFGF, lipid peroxidation levels decreased, and the activities of GSH-Px and concentrations of TAS improved in the oral epithelium. However, zinc and copper levels were decreased in the oral epithelium by BP and bFGF treatments. Concentrations of vitamin E and reduced glutathione in the samples did not change in the groups. In conclusion, treatment with bFGF modulated the antioxidant redox system and reduced the oral epithelium oxidative stress induced by BP. However, zinc and copper levels were decreased by BP and bFGF treatments.

Effect of Zinc Supplementation on Antioxidant Defenses and Oxidative Stress Markers in Patients Undergoing Chemotherapy for Colorectal Cancer: a Placebo-Controlled, Prospective Randomized Trial

“…However, it has been postulated that endogenous antioxidants are not sufficient to prevent oxidative stress and that the addition of exogenous antioxidant nutrients may reduce the intensity of oxidative stress. The antioxidant activity of zinc has been demonstrated to act as an antioxidant agent in animal [9,10] and human [4,11] studies. In addition to acting as a cofactor of SOD enzyme [5], zinc also increases the expression [12] and synthesis [10] of metallothionein, a free radical scavenger that protects cells and tissues from oxidative stress [10].…”

Zinc Oxide Nanoparticles Reduce Apoptosis and Oxidative Stress Values in Isolated Rat Pancreatic Islets

“…To the best of our knowledge, there is no report about ZnO NP effects in pancreatic islets. However, we know that zinc (Zn) has a key role in a variety of essential processes such as RNA, DNA, and protein synthesis [19]. Meanwhile, modulating Zn deficiency in diabetic patients leads to a balanced oxidant/antioxidant level [20].…”

Effects of Fermented Mushroom of Cordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer

“…It has been proposed that antioxidant changes reflect an altered redox balance in several pathological states [28]. LDH was measured to evaluate the role of antioxidative stress in the protection of Se-CS.…”