Basic Fibroblast Growth Factor Infusion Increases Tumour Vascularity, Blood Flow and Chemotherapy Uptake

Correlation between tumor blood flow assessed by perfusion CT and effect of neoadjuvant therapy in advanced esophageal cancers

“…On the other hand, redundant blood flow (BF) in cancer tissue is of great advantage for cancer therapies such as ChT and radiotherapy. From the drug delivery viewpoint, tumors with more angiogenesis showed higher concentration of anti-cancer drugs in the cancer tissue [11,12]. Tumor hypoxia and acidosis by anaerobic metabolism induce chemo-resistance and anti-apoptosis by various pathways, including hypoxia inducible factor-1, BNIP-3, proton pump inhibitor, and AKT [13][14][15].…”

Effect of manipulation of primary tumour vascularity on metastasis in an adenocarcinoma model

“…This was consistent with the significant in vivo increases in flank tumour proliferation and growth that occurred with bFGF infusion. Intratumoural and systemic bFGF infusion increase tumour vascularity and blood flow in both the HSN sarcoma and the K12/TR adenocarcinoma cell lines (Davies et al, 2001). Since the HSN cell line does not proliferate in response to in vitro bFGF or grow more rapidly in vivo on exposure to bFGF (Mathur et al, 1999), it is most likely that the bFGF-related tumour vascularity response was independent of tumour type -for example deriving from a bFGF effect on host endothelial cells.…”

“…bFGF was delivered at a dose rate of 5 mg per 24 h. This dose has previously been demonstrated to increase liver metastasis vascularity when infused systemically in a rat fibrosarcoma model (Davies et al, 2001). …”

Antitumor activity of Soamsan, a traditional Korean medicine, via suppressing angiogenesis and growth factor transcription

“…This study examined whether Soamsan could regulate the mRNA transcription of growth factors, VEGF, TGF-␤ and bFGF (Davies et al, 2002;Derynck et al, 2001;Goldman et al, 1998). HT1080 cells derived from a metastatic lesion of a human fibrosarcoma were inoculated at a density of 1 × 10 5 cells in six-well plates and cultured in MEM supplemented with 10% heat-inactivated fetal bovine serum, 100 units/ml penicillin and 100 g/ml streptomycin.…”

“…Tumor development and metastasis are associated with increased release of various angiogenic factors, most prominently of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and transforming growth factor-␤ (TGF-␤). VEGF expression is elevated in a wide variety of solid tumors and thought to support their growth by enhancing tumor neovascularization (Claffey et al, 1996;Goldman et al, 1998), and systemic infusion of bFGF enhances the tumor neovascularization (Davies et al, 2002). In the vascular system, TGF-␤ regulates the process of angiogenesis, which involves the activation, remodeling and expansion of pre-existing vascular networks.…”