Basic In Vitro Experiment on the Adhesive Effects of Sheet-Type Hemostatic Agents Used in Combination with a Liquid Fibrin Sealant

Abstract

It is important to obtain further comparative data among agents and select the appropriate agents, taking into consideration the type of surgery.

The Physiological Incubation Biosimulator (PIBS): An Improved Ex Vivo Experimental Setup for the Mechanical Stability of Biological Sealants in Surgical Procedures

“…On the other hand, they are often performed in nonphysiological conditions like room temperature and the measured endpoint is often shortterm maximal burst pressure, which might not be the most clinically relevant quality. [9][10][11][12][13][14][15]21 Only 2 studies evaluated the mechanical resistance over a longer period than a few minutes. 22,23 Two other studies evaluated the biochemical 24 and the structural effects of a long-term incubation with biological fluids.…”

“…The majority of these experiments focused on the maximal mechanical stress necessary to compromise the sealant's stability. [9][10][11][12][13][14][15] Other studies evaluated the effects of long-term biochemical degradation of fibrin sealants under physiological conditions without mechanical stress. 16,17 A combined ex vivo analysis of multiple aspects (mechanical stress + biochemical degradation + physiological surrounding) has not been performed so far.…”