Basic Parameters of Blood Count as Prognostic Factors for Renal Cell Carcinoma

Abstract

Background. Renal cell carcinoma is the most common type of kidney cancer. Taking account of morbidity and mortality increase, it is evident that searching for independent prognostic factors is needed. Aim of the Study. The aim of the study was to analyze routinely performed blood parameters as potential prognostic factors for kidney cancer. Material and Methods. We have retrospectively reviewed the records of 230 patients treated for renal cell carcinoma in the years 2000–2006. Preoperative blood parameters, postoperative histopathological results, and staging and grading were performed. To estimate the risk of tumor recurrence and cancer specific mortality (CSM) within five years of follow-up, uni- and multivariate Cox and regression analyses were used. To assess the quality of classifiers and to search for the optimal cut-off point, the ROC curve was used. Results. T stage of the tumor metastasis is the most important risk factor for early recurrence and cancer specific mortality (p < 0.001). The preoperative platelet count (PLT) above 351 × 103/uL (95.3%; 55.1%) and AUC of 77% are negative prognostic factors and correlate with increased cancer specific mortality (CSM) during the five-year follow-up (p < 0.001). Increased risk of local recurrence was observed for PLT above 243.5 × 103/ul (59%; 88%) and AUC of 80% (p = 0.001). The opposite was observed in the mean platelets volume (MPV) for cancer specific mortality (CSM). The cut-off point for the MPV was 10.1 fl (75.4%; 55.1%) and for the AUC is of 68.1% (p = 0.047). Conclusions. Many analyzed parameters in univariate regressions reached statistical significance and could be considered as potential prognostic factors for ccRCC. In multivariate analysis, only T stage, platelet count (PLT), and mean platelet volume (MPV) correlated with CSM or recurrent ccRCC.

Neutrophil-to-mean platelet volume ratio as a new predictor for overall and cancer-specific survival in patients with localized clear cell renal cell carcinoma

“…Seles et al defined MPV lower than 9.5 fl as a negative prognostic factor for CSS [22]. Prokopowicz et al proposed the MPV cut-off value as 10.1 fl, given that patients with lower values suffered from significantly higher cancer-specific mortality [21]. Yun et al discovered that patients with MPV lower than 7.5 fl had shorter OS [23].…”

“…Decreased MPV was associated with decreased survival in non-small cell lung cancer and esophageal cancer patients [19,20]. In RCC patients, two studies confirmed MPV as an independent prognostic factor for cancer-specific survival (CSS) [21,22] and one study proved it to be an independent prognostic factor of OS [23].…”

<p>Prognostic Role of Prothrombin Time Activity, Prothrombin Time, Albumin/Globulin Ratio, Platelets, Sex, and Fibrinogen in Predicting Recurrence-Free Survival Time of Renal Cancer</p>

“…Studies have indicated that the renal cancer patients who have thrombocytosis mostly have unfavourable prognoses after surgery. 21 , 30 , 36 Our study has indicated that a high level of PLT could be a risk factor for the recurrence of renal cancer.…”

Mean platelet volume-to-lymphocyte ratio: a novel biomarker associated with overall survival in patients with nonmetastatic clear cell renal cell carcinoma treated with nephrectomy

“…The solution might be found in cheap and easy obtainable blood-based indicators. Different complete blood count (CBC) parameters were reported to have an association with overall survival in RCC, such as neutrophil count, platelet count, neutrophil-to-lymphocyte ratio and mean platelet volume [16][17][18][19][20][21]. These markers are routinely used in everyday practice.…”