Basic Properties of Boron Carbide

Gosset, Dominique

doi:10.1016/b978-0-12-803581-8.11638-8

Cited by 10 publications

(11 citation statements)

References 85 publications

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“…In addition, NPs present a much lower clearance than the easily degradable molecule [ 10 ], suggesting the possibility of realizing subsequent BNCT treatments with a single administration. Finally, B 4 C offers high chemical inertness, ensuring that no harmful components are released during its permanence in the organism [ 12 , 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Gd-Functionalized B4C Nanoparticles for BNCT Applications

Vitali

Demichelis

Martino

et al. 2023

Life

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Inorganic nanoparticles of boron-rich compounds represent an attractive alternative to boron-containing molecules, such as boronophenylalanine or boranes, for BNCT applications. This work describes the synthesis and biological activity of multifunctional boron carbide nanoparticles stabilized with polyacrylic acid (PAA) and a gadolinium (Gd)-rich solid phase. A fluorophore (DiI) was included in the PAA functionalization, allowing the confocal microscopy imaging of the nanoparticles. Analysis of the interaction and activity of these fluorescent Gd-containing B4C nanoparticles (FGdBNPs) with cultured cells was appraised using an innovative correlative microscopy approach combining intracellular neutron autoradiography, confocal, and SEM imaging. This new approach allows visualizing the cells, the FGdBNP, and the events deriving from the nuclear process in the same image. Quantification of 10B by neutron autoradiography in cells treated with FGdBNPs confirmed a significant accumulation of NPs with low levels of cellular toxicity. These results suggest that these NPs might represent a valuable tool for achieving a high boron concentration in tumoral cells.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Gd-Functionalized B4C Nanoparticles for BNCT Applications

Vitali

Demichelis

Martino

et al. 2023

Life

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“…Boron carbide (B 4 C) emerges as particularly noteworthy due to its high volumetric concentration of boron atoms, comparable to that of elemental boron. Furthermore, boron carbide exhibits exceptional chemical inertness and high biocompatibility [23,24]. B 4 C NPs have already been investigated as possible 10 B carriers for BNCT [25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of B4C-Based Multifunctional Nanoparticles for Boron Neutron Capture Therapy Applications

Demichelis,

Portu,

Gadan

et al. 2024

Applied Nano

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Nanoparticles composed of inorganic boron-containing compounds represent a promising candidate as 10B carriers for BNCT. This study focuses on the synthesis, characterization, and assessment of the biological activity of composite nanomaterials based on boron carbide (B4C). Boron carbide is a compelling alternative to borated molecules due to its high volumetric B content, prolonged retention in biological systems, and low toxicity. These attributes lead to a substantial accumulation of B in tissues, eliminating the need for isotopically enriched compounds. In our approach, B4C nanoparticles were included in composite nanostructures with ultrasmall superparamagnetic nanoparticles (SPIONs), coated with poly (acrylic acid), and further functionalized with the fluorophore DiI. The successful internalization of these nanoparticles in HeLa cells was confirmed, and a significant uptake of 10B was observed. Micro-distribution studies were conducted using intracellular neutron autoradiography, providing valuable insights into the spatial distribution of the nanoparticles within cells. These findings strongly indicate that the developed nanomaterials hold significant promise as effective carriers for 10B in BNCT, showcasing their potential for advancing cancer treatment methodologies.

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“…It slow density (2.52 g/cm 3 ) [1] combined with its high hardness (over 30 GPa) [1][2][3][4] allows boron carbide to be used as armor plates in ballistic applications. The material is also characterized by a wide active cross-section for thermal neutron capture (755 b) [5], making it the best material for the construction of neutron diodes. This property also allows B 4 C to be considered a candidate for the role of a boron carrier in boron neutron capture therapy (BNCT) [6,7].…”

Section: Introductionmentioning

confidence: 99%

The Hydrothermal Method of Preparing Boron–Saccharide Precursors for the Synthesis of Boron Carbide and Its Influence on the Morphology and Phase Composition of the Obtained Products

Kozień,

Pasiut,

Banaś

et al. 2024

Crystals

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Owing to its properties, boron carbide has been applied in scientific and industrial fields. For this reason, B4C powders should be characterized by high purity and homogeneity in grain size and shape. In this study, boron carbide was prepared using precursors obtained using a hydrothermal method, and the grain morphology of the product was investigated. Boric acid and the saccharides glucose, fructose, inulin, and sorbitol were used as the precursors. Two precursor dehydration methods, freeze-drying and recrystallization, were compared. The precursors were subjected to DLS grain size and FT-IR spectrophotometric studies, and SEM observations of the precursors and products were performed, confirming that boron carbide powders could be successfully synthesized.

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Basic Properties of Boron Carbide

Cited by 10 publications

References 85 publications

Synthesis and Characterization of Gd-Functionalized B4C Nanoparticles for BNCT Applications

Synthesis and Characterization of Gd-Functionalized B4C Nanoparticles for BNCT Applications

Synthesis and Characterization of B4C-Based Multifunctional Nanoparticles for Boron Neutron Capture Therapy Applications

The Hydrothermal Method of Preparing Boron–Saccharide Precursors for the Synthesis of Boron Carbide and Its Influence on the Morphology and Phase Composition of the Obtained Products

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