Basic Science as a Prescription for Breakthrough Inventions in the Pharmaceutical Industry

Malva, Antonio Della; Leten, Bart; Kelchtermans, Stijn; Veugelers, Reinhilde

doi:10.2139/ssrn.2382522

Cited by 6 publications

(12 citation statements)

References 61 publications

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“…4 We used a fixed 4-year window to calculate the forward citations. It is important to note that we depart from the existing literature, 5 which frequently uses patents to measure the performance of R&D activities (e.g., Almeida & Phene, 2004; Della Malva, Kelchtermans, Leten, & Veugelers, 2015). The main reason is that it is difficult to identify the origin of patents in MNCs.…”

Section: Methodsmentioning

confidence: 98%

“…We classified publications as reporting on applied or basic research on the basis of the journal in which they are published, using the CHI journal classification. This classification assigns Web of Science journals to one of four research levels in a spectrum ranging from very applied research (Level 1) to very basic research (Level 4; Della Malva et al, 2015; Hicks et al, 1996). The variable basic research orientation measures the share of publications of an R&D subsidiary classified in CHI Level 4, using a 5-year lagged window.…”

Section: Methodsmentioning

confidence: 99%

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Multistep Knowledge Transfer in Multinational Corporation Networks: When Do Subsidiaries Benefit From Unconnected Sister Alliances?

Faems

Bos²,

Noseleit

et al. 2018

Journal of Management

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In this paper, we explore under which conditions subsidiaries of multinational corporations can benefit from the external networks of sister subsidiaries in terms of new knowledge generation. We focus on the phenomenon of unconnected sister alliances—that is, alliances of sister subsidiaries with whom the focal subsidiary lacks a recent history of internal R&D collaboration. Whereas unconnected sister alliances provide knowledge recombination opportunities for the focal subsidiary, realizing them is challenging because of particular knowledge transfer frictions. In this paper, we theorize on how particular conditions (i.e., headquarters proximity, knowledge overlap, size of focal subsidiary’s own alliance network) influence the strength of these frictions, resulting in hypotheses on how these conditions moderate the relationship between the number of unconnected sister alliances and the generation of new knowledge by focal subsidiaries. We rely on a panel data set of 2,258 R&D subsidiaries belonging to 118 firms in the pharmaceutical industry to empirically test our hypotheses. Jointly, our findings enrich our current theoretical understanding of how different types of external linkages and their interactions shape subsidiaries’ generation of new knowledge. We also illuminate the opportunities and challenges that multistep knowledge transfer processes entail.

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Section: Methodsmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Multistep Knowledge Transfer in Multinational Corporation Networks: When Do Subsidiaries Benefit From Unconnected Sister Alliances?

Faems

Bos²,

Noseleit

et al. 2018

Journal of Management

Self Cite

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show abstract

“…In this view, radicalness is identified by its capacity to generate shifts in the technological trajectory and is conceptualized as a process stemming from the recombination of components and the exploitation of new knowledge domains (Schumpeter, 1934). In this approach, radical inventions often are investigated at firm level and identified as technologies that emerge from the exploitation of knowledge residing outside the firm's boundaries (Rosenkopf and Nerkar, 2001;Ahuja and Lampert, 2001;Della Malva et al, 2015). Whether conceptualized at level of the firm (Henderson and Cockburn, 1994;Rosenkopf and Nerkar, 2001) or the technology (Fleming, 2001;Shane, 2001;Verhoeven et al, 2016), radical inventions are regarded theoretically as the output of some recombination processes (Fleming, 2001;Carnabuci and Operti, 2013).…”

Section: Defining and Identifying Radical Inventionsmentioning

confidence: 99%

The division of labour between academia and industry for the generation of radical inventions

2018

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SEEDS is an interuniversity research centre. It develops research and higher education projects in the fields of ecological and environmental economics, with a special focus on the role of policy and innovation. Main fields of action are environmental policy, economics of innovation, energy economics and policy, economic evaluation by stated preference techniques, waste management and policy, climate change and development.The SEEDS Working Paper Series are indexed in RePEc and Google Scholar. Papers can be downloaded free of charge from the following websites: http://www.sustainability-seeds.org/.

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“…Inventors who rely primarily on theoretical scientific knowledge, when interacting with academics are more likely to produce more radical inventions, than inventors who rely primarily on applied knowledge (Carpenter et al, 1980;Della Malva et al, 2014). This is because scientific knowledge helps to guide the inventor through the technological landscape and to identify more useful combinations of previously unrelated knowledge domains (Gruber et al, 2013), and reduces the effort expended on fruitless search (Fleming and Sorenson, 2004).…”

Section: Appropriation Of Project Outcomesmentioning

confidence: 99%

Which governance of university–industry interactions increases the value of industrial inventions?

Fassio

Geuna

Rossi

2018

Industrial and Corporate Change

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While evidence suggests that industry inventors' interactions with universities enhance invention value, the role of interaction governance has so far been overlooked. Relying on an original survey of industry inventors of European patents based in Italy, we show that governance matters. Personal contractual collaborations between firms and individual academics lead to higher-value inventions than collaborations mediated by university institutions. The former enable more effective exploitation of academic knowledge, by facilitating its full transmission and integration into the firm's knowledge base.

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Basic Science as a Prescription for Breakthrough Inventions in the Pharmaceutical Industry

Cited by 6 publications

References 61 publications

Multistep Knowledge Transfer in Multinational Corporation Networks: When Do Subsidiaries Benefit From Unconnected Sister Alliances?

Multistep Knowledge Transfer in Multinational Corporation Networks: When Do Subsidiaries Benefit From Unconnected Sister Alliances?

The division of labour between academia and industry for the generation of radical inventions

Which governance of university–industry interactions increases the value of industrial inventions?

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