Basic Studies in Mongolism Ii. Hemoglobin1

Mj, Carver

doi:10.1097/00005053-195810000-00008

Cited by 6 publications

(3 citation statements)

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“…normal total y-globulin serum levels in this syndrome [3,4,5,18,23,40,63,72,82,86,88,89,92]. It has been suggested that the increased frequency of infections in patients with Down's syndrome is because most of them are institutionalized and are thus subjected to environ mental conditions involving more frequent exposures to infective agents, or that it is due to the concomitant vitamin A deficiency [32,34], Nevertheless, the environmental conditions at the institutions may not be sufficient to explain the higher frequency of infections in Down's syndrome patients, as other types of institutionalized retar dates do not show as high a frequency of infections [23,83].…”

mentioning

confidence: 81%

Impaired in vitro Response of Circulating Lymphocytes to Phytohemagglutinin in Down’s Syndrome: Dose- and Time-Response Curves and Relation to Cellular Immunity

Rigas

Elsasser

Hecht³

1970

Int Arch Allergy Immunol

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mentioning

confidence: 81%

Impaired in vitro Response of Circulating Lymphocytes to Phytohemagglutinin in Down’s Syndrome: Dose- and Time-Response Curves and Relation to Cellular Immunity

Rigas

Elsasser

Hecht³

1970

Int Arch Allergy Immunol

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“…Duplicate analyses were performed simultaneously upon sera from the mother, the child and from an apparently normal non-institutionalized adult male. The data expressed as percent of the total protein provided by the separable components are presented in Table I, along with mean values and their standard deviations published by Carver, Wiltse, * Data of Carver, et al (1959) and Wittson (1959). The latter values were obtained under the same conditions as in the present study except that the constant current was 9 rather than 8 microamperes.…”

Section: Serum Proteinsmentioning

confidence: 63%

Reproduction in a Mongoloid

Stiles

Goodman

1961

Acta genet. med. gemellol.

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Reproduction in mongoloids is a rarity. Allen and Baroff (1955) cite only four reports prior to 1949 which described such instances and Øster (1953) considered the diagnoses uncertain in two of those reports. At least seven more recent instances have been recorded (Le Long, Borniche, Kreisler, and Baudy, 1949; Sawyer, 1949; Forsmann and Thysell, 1957; Rehn and Thomas, 1957; Schlaug, 1957; Mullins, Estrada, and Gready, 1960; and Hanhart, 1960). In four of those cases the offspring were non-mongoloid and in three, mongoloid. The case described by Rehn and Thomas (op. cit.) is the subject of this report. Because those authors were aware of the present comprehensive study, their diagnoses of mongolism were based on only routine clinical examinations. The purpose in making this investigation was to determine whether or not both the mother and her female offspring were mongoloid. Toward that end the mother and child were examined carefully for the presence of the various stigmata of mongolism. The results of those examinations are presented below. The mother in the present case was living at home when 19 years of age and would probably not have been committed to an institution had she not become pregnant. She was committed with the diagnosis of mongolism and pregnancy three months prior to delivery and remained a patient at the institution until released on home parole a few months following delivery. Her child was committed with a diagnosis of mongolism shortly after birth and has never been away from the institution. Paternity is unknown, though the mother's father has been suspected.

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“…cate that alterations occur in the activity of many enzymes [2, 3, 9, 10, 18, 25-27, 34, 39, 41, 48, 501, in Although no study has been conducted to determine the level of some plasma electrolytes [23,461, in the the basic pharmacology of an agent in Down's syn-ratio of plasma proteins and hard tissue proteins [l,5, drome, the available evidence suggests the presence 13,19,36,40,42,45,47], and in the excretion of some of subnormal or abnormal physiological and biochem-intermediary metabolites [19-22, 33, 35, 51, 531 in ical functions in this condition. Biochemical data indi-children with Down's syndrome.…”

Section: Introductionmentioning

confidence: 99%

Alteration in Metabolism of Ace tylsalicylic Acid in Children with Down's Syndrome: Decreased Plasma Binding and Formation of Salicyluric Acid

Ebadi¹,

Kugel²

1970

Pediatr Res

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ExtractThis paper reports the differences in absorption and distribution in plasma of free and bound salicylate, and the differences in excretion of salicylic and salicyluric acid in the urine of children with Down's syndrome and in control subjects. After oral administration of a single dose of acetylsalicylic acid (35 mg/kg) to normal children, the peak level of salicylic acid in plasma occurred in 2 h and the drug level returned to the base line at approximately 8 h; in children with Down's syndrome, the peak level of salicylic acid occurred in 4 h and the drug level returned to a base line at approximately 16 h. In children with Down's syndrome, the 24-h excretion of salicylate metabolites in the urine indicated a higher level of free salicylic acid (table I) and a lower level of salicyluric acid (tables I1 and 111) when compared with the control group. Although the concentration of salicylate is small in erythrocytes, children with Down's syndrome showed a higher level when compared with their normal counterpart (table IV). The in vitro plasma-binding studies indicated that in comparison with normal subjects, children with Down's syndrome were less capable of binding salicylate (table V). SpeculationPatients with Down's syndrome are a highly abnormal group of individuals because of their morphological, physiological and biochemical aberrations. They are directed and influenced by their abnormalities, one manifestation of which is altered pharmacogenetics. It should be expected that any therapeutic regime must take these differences into consideration and dosage must be calculated not on the basis of body weight but according to the plasma level of the drug or of its active metabolites. Introductioncate that alterations occur in the activity of many enzymes [2,

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Basic Studies in Mongolism Ii. Hemoglobin1

Cited by 6 publications

References 0 publications

Impaired <i>in vitr</i><i>o</i> Response of Circulating Lymphocytes to Phytohemagglutinin in Down’s Syndrome: Dose- and Time-Response Curves and Relation to Cellular Immunity

Impaired <i>in vitr</i><i>o</i> Response of Circulating Lymphocytes to Phytohemagglutinin in Down’s Syndrome: Dose- and Time-Response Curves and Relation to Cellular Immunity

Reproduction in a Mongoloid

Alteration in Metabolism of Ace tylsalicylic Acid in Children with Down's Syndrome: Decreased Plasma Binding and Formation of Salicyluric Acid

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