Basic TLC Techniques, Materials, and Apparatus

Quantitative determination of 3,4-methylenedioxymethamphetamine by thin-layer chromatography in ecstasy illicit pills in Tehran

“…However previous studies have shown the efficiency of the 'scraping off' method in TLC (Gänshirt 1969 Shetab Boushehri et al 2007). Comparative studies have shown that quantitative TLC procedures using elution of the separated substances have no greater range of error than other comparable analytical methods (Gänshirt 1969;Sherma 2003;Wall 2005).…”

“…As recreational use of ecstasy has dramatically increased in recent years, deaths related to its use have been reported (Ling et al 2001;Aronson 2005;Bigelow 2006). Thin-Layer Chromatography (TLC) is a simple, rapid, inexpensive, and relatively precise and sensitive method for analysis of drugs and poisons (Stahl 1969;Moffat 1986;Sherma 2003;Poole 2004;Wall 2005;Hahn-Deinstrop 2007). Simultaneous quantitative determination of drugs and poisons has made it a rapid method (Stahl 1969;Moffat 1986;Sherma 2003;Poole 2004;Wall 2005;Hahn-Deinstrop 2007).…”

Comparison of liquid-liquid extraction-thin layer chromatography with solid-phase extraction-high-performance thin layer chromatography in detection of urinary morphine

“…Thin layer chromatography (TLC) is one of the most useful, simple, inexpensive, rapid, relatively precise and sensitive methods for separation, identification, and quantification of drugs, poisons, and herbal medicines[9]–[14]. TLC and high performance TLC (HPTLC) have found many applications in analytical chemistry[15], analytical toxicology[16],[17], and pharmaceutical industries[18], including monitoring organic reactions and qualitative analysis of reaction products[19], detection of drugs and poisons in biological and non-biological materials[13],[16],[17], identifying compounds present in a given substance[9]-[14], assaying the purity of pharmaceuticals[18], and determination of the components of plant extracts[20],[21].…”

“…TLC and high performance TLC (HPTLC) have found many applications in analytical chemistry[15], analytical toxicology[16],[17], and pharmaceutical industries[18], including monitoring organic reactions and qualitative analysis of reaction products[19], detection of drugs and poisons in biological and non-biological materials[13],[16],[17], identifying compounds present in a given substance[9]-[14], assaying the purity of pharmaceuticals[18], and determination of the components of plant extracts[20],[21]. Alumina, kieselguhr, cellulose, and silica gel are among the adsorbents used as stationary phases in TLC[9]-[14]. Silica gel is by far the most widely used adsorbent in TLC[9]-[14].…”

“…Alumina, kieselguhr, cellulose, and silica gel are among the adsorbents used as stationary phases in TLC[9]-[14]. Silica gel is by far the most widely used adsorbent in TLC[9]-[14]. TLC silica gel is a porous inorganic material, which is characterized by particle size (5-17 µm), pore size (60 Å), pore volume (0.75 ml/g), specific gravity (2.1 g/cm 3 ), specific surface (BET) (500 m 2 /g), and pH stability (2-8)[9]-[13],[20].…”