Cone beam computed tomography (CBCT) has become a common diagnostic method in endodontics. However, the current literature provides insufficient information about different aspects that are related to the use of CBCT, such as: the efficacy of CBCT to support the practitioner's clinical decision making and to affect treatment outcomes; about the required training of the practitioner so he can efficiently examine the entire region that appears in the CBCT scan and diagnose abnormalities or possible pathologies; and on the long-term health risks associated with the use of CBCT in endodontics. In addition, CBCT has the strong potential to be used for accurate diagnosis of complete and uneventful healing. In this thematic series, we call for manuscripts that discuss aspects of the use of CBCT in endodontics.