Basis of Selectivity of Triflusulfuron Methyl in Sugar Beets (Beta vulgaris)

Wittenbach, Vernon A.; Koeppe, Mary K.; Lichtner, Francis T.; Zimmerman, William T.; Reiser, R. W.

doi:10.1006/pest.1994.1035

Cited by 21 publications

(16 citation statements)

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“…Sulphonylureas are among the world's most important herbicides and stunt plant growth by inhibiting the enzyme acetolactate synthase, which is apparently absent in animals [122]. The effects of sulphonylurea herbicides on insulin secretion have not been documented in the literature.…”

Section: Other Actions Of Sulphonylureasmentioning

confidence: 99%

ATP-sensitive K + channels and insulin secretion: their role in health and disease

Ashcroft

Gribble²

1999

Diabetologia

410

279

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IntroductionSulphonylureas have been used for over 50 years to enhance insulin secretion in patients with Type II (non-insulin-dependent) diabetes mellitus but their therapeutic target was not discovered until 1985 and we are only just beginning to address their molecular mechanism of action. The sulphonylurea drugs were discovered serendipitously by Marcel Janbon in 1942, when he observed a high incidence of hypoglycaemic symptoms in typhoid patients treated with the bacteriostatic agent p-aminobenzenesulphamidoisopropylthiodiazole (2254RP) [1]. This observation was extended by Auguste Loubatires, who showed that 2254RP induced hypoglycaemia in dogs by stimulating insulin secretion [2]. Subsequently, it was discovered that another sulphonamide drug being tested for bacteriostatic effects, carbutamide, also caused hypoglycaemia in man [3]. Clinical studies followed and led to the development of tolbutamide for the treatment of Type II diabetes. The full story of these pioneering experiments has been vividly recounted in an earlier review by Henquin [4]. Numerous sulphonylureas and related compounds have now been synthesized, with different potencies and time-courses of action and many millions of Type II diabetic patients are now routinely treated with these drugs.The first clues to the mechanism of action of sulphonylureas on insulin secretion came with the discovery that these drugs depolarize the pancreatic beta cell and stimulate electrical activity [5] and the finding that this depolarization was due to a decrease in the potassium permeability of the beta-cell membrane [6]. Patch-clamp studies subsequently showed that sulphonylureas interact specifically with the ATP-sensitive potassium (K ATP ) channel in the betacell membrane and bring about its closure [7]. The activity of the K ATP channel sets the resting membrane potential of the unstimulated beta cell and its closure decreases the membrane K + permeability, producing membrane depolarization and insulin secretion [8]. Radioligand binding studies established the presence of both low-affinity and high-affinity sulphonylurea binding sites in the beta-cell membrane [9, 10] and led to considerable speculation about whether the high-affinity sulphonylurea receptor and the K ATP channel were the same or different proteins. The purification and subsequent cloning of a high-affinity sulphonylurea receptor from insulinoma cells [11] resolved this issue by showing that this receptor is an integral component of the K ATP channel [12,13].In this article, we review the role of the K ATP channel in insulin secretion in health and disease. We also summarise current knowledge of how sulphonylureas act on the different types of K ATP channel found in beta cells and in extra-pancreatic tissues, and discuss the implications of these findings for the use of sulphonylureas as therapeutic agents to stimulate insulin secretion in humans. Finally, we consider the evidence for additional targets for sulphonylureas, both within the beta cell and in extra-pancreatic tissues.Funct...

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Section: Other Actions Of Sulphonylureasmentioning

confidence: 99%

ATP-sensitive K + channels and insulin secretion: their role in health and disease

Ashcroft

Gribble²

1999

Diabetologia

410

279

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“…Several major classes of herbicides including sulfonylureas (chlorimuron ethyl [Brown and Neighbors, 1987], trisulfuron methyl [Wittenbach et al, 1994], and flupyrsulfuronmethyl [Koeppe et al, 1998]), triazines (atrazine), chloroacetanilides (alachlor [Shimabukuro et al, 1971] and metolachlor [Cottingham and Hatzios, 1992]), thiocarbamate sulfoxides (S-ethyl dipropylthiocarbamate sulfoxide [Cottingham et al, 1993]), and diphenylethers (flurodifen) are found as a GSH conjugate and this conjugate is (typically) no longer toxic to the target enzyme. More direct proof of the importance of GSTs in protection from xenobiotics is that the expression of maize GSTIV in tobacco provides protection from metolachlor (Jepson et al, 1997).…”

mentioning

confidence: 99%

A Genomics Approach to the Comprehensive Analysis of the Glutathione S-Transferase Gene Family in Soybean and Maize

McGonigle

Keeler²,

Lau³

et al. 2000

Plant Physiology

283

264

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By BLAST searching a large expressed sequence tag database for glutathione S-transferase (GST) sequences we have identified 25 soybean (Glycine max) and 42 maize (Zea mays) clones and obtained accurate full-length GST sequences. These clones probably represent the majority of members of the GST multigene family in these species. Plant GSTs are divided according to sequence similarity into three categories: types I, II, and III. Among these GSTs only the active site serine, as well as another serine and arginine in or near the “G-site” are conserved throughout. Type III GSTs have four conserved sequence patches mapping to distinct structural features. Expression analysis reveals the distribution of GSTs in different tissues and treatments: Maize GSTI is overall the most highly expressed in maize, whereas the previously unknown GmGST 8 is most abundant in soybean. Using DNA microarray analysis we observed increased expression among the type III GSTs after inducer treatment of maize shoots, with different genes responding to different treatments. Protein activity for a subset of GSTs varied widely with seven substrates, and any GST exhibiting greater than marginal activity with chloro-2,4 dinitrobenzene activity also exhibited significant activity with all other substrates, suggesting broad individual enzyme substrate specificity.

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“…The mechanism of selectivity was studied by comparing the response of sugar beets with that of sensitive weeds such as rapeseed (Brassica napus), scentless false mayweed (Matricaria inodora), and common field-speedwell (Veronica persica) and a moderately tolerant lambsquarters (Chenopodium album) [75]. A good correlation between metabolism and plant tolerance does exist.…”

Section: Herbicidementioning

confidence: 99%

Herbicide Metabolism in Weeds — Selectivity and Herbicide Resistance

Jablonkai¹

2015

Herbicides, Physiology of Action, and Safety

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The metabolic detoxication/bioactivation pathways, the levels and activity of enzymes, and endogenous cofactors mediating these reactions in crops have been well documented; however, much less evidence has been accumulated in weed species. The herbicide metabolism as a selectivity factor is summarized with special attention to acetyl-CoA carboxylases (ACCase)-inhibiting aryloxyphenoxypropionate, protoporphyrinogen IX oxidase (PPO) inhibitor, carotenoid biosynthesis inhibitor clomazone, and acetolactate synthase (ALS) inhibitor imidazolinone and sulfonylurea herbicides in various weed species. The metabolism-based herbicide resistance related to these herbicide classes is also discussed along with the role and level of metabolizing enzymes and cofactors in weed species.

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Basis of Selectivity of Triflusulfuron Methyl in Sugar Beets (Beta vulgaris)

Cited by 21 publications

References 0 publications

ATP-sensitive K + channels and insulin secretion: their role in health and disease

ATP-sensitive K + channels and insulin secretion: their role in health and disease

A Genomics Approach to the Comprehensive Analysis of the Glutathione S-Transferase Gene Family in Soybean and Maize

Herbicide Metabolism in Weeds — Selectivity and Herbicide Resistance

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