Basistherapeutika

Daniels, Rolf

doi:10.1007/s00105-017-4044-y

Cited by 8 publications

(1 citation statement)

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“…In order to support these endogenous repair processes and to stabilize the skin barrier, a consistent basic therapy is required in addition to the therapy with topical glucocorticosteroids. The aim is to reduce or ideally prevent eczema attacks [11]. Ideally, products are used to stabilize the barrier function by improving the ability to bind moisture and compensate for the lack of barrier lipids [12].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Lipid Foam Cream and Basic Cream on Epidermal Reconstruction in Mild Atopic Eczema

Dähnhardt¹,

Dähnhardt‐Pfeiffer²,

Schulte-Walter³

et al. 2022

Skin Pharmacol Physiol

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Introduction: Basic therapy is of central importance in the treatment of atopic eczema. Using electron microscopic images, the morphology of epidermal skin barrier and its lipids was investigated after application of a lipid foam cream and basic cream. Methods: Patients with two contralateral comparable atopic eczema (local SCORAD 1-10) on the forearms were tested. Eczema was treated with a lipid foam cream or basic cream twice daily for 28 days. At the beginning, after 14 days and at the end of application, the local SCORAD, transepidermal water loss (TEWL), skin hydration, intercellular lipid length (ICLL) in the intercellular space (ICS) of the stratum corneum (SC) and skin lipids were determined. Results: After application of the foam cream, the epidermal skin barrier could be completely restored and corresponded to skin-healthy skin, while the epiderrmal skin barrier could not reach this state after care with the basic cream. The content of lipids in the SC increases significantly by 31% after basic cream treatment, whereas they are significantly increased by 85% after application of the lipid foam cream. The local SCORAD improved for both treatments to about the same extent, no significant results could be shown for TEWL and skin hydration. Conclusion: In subjects with mild atopic eczema, the lipid foam cream leads to a measurable recovery of the skin barrier which is much more pronounced in comparison to the basic cream

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Section: Introductionmentioning

confidence: 99%