Basit Bir Tam Kan Sayımı Gestastonel Diyabetes Mellitusu Öngörebilir Mi?

Abstract

To assess the role of simple complete blood count (CBC) in prediction of gestational diabetes (GDM). Material and Method: Pregnant women screened for GDM in 24-28 gestational weeks with a 75g-OGTT between January 2018-January 2020 were retrospectively investigated. Patients with a known systemic disease, using aspirin, low-molecular-weight heparin and steroids were excluded. A total of 359 patients (81 with GDM and 278 controls) were enrolled. The assessed parameters in CBC were hemoglobin, hematocrit, red blood cells, mean corpuscular volume, mean corpuscular hemoglobin concentration, white blood cells (including neutrophils, lymphocytes, monocytes, eosinophils, basophils), platelets, platelet distribution width (PDW), mean platelet volume (MPV), red cell distribution width (RDW), nucleated red blood cell (NRBC), NRBC percentage, plateletcrit (PCT), platelet large cell ratio (P-LCR), immature granulocytes (IG) and IG percentage. Platelet mass index (PMI), neutrophil-tolymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) were calculated. These parameters were compared between GDM patients and controls. Regression analysis was performed with the parameters that were significantly correlated with GDM. ROC curve analysis was done in order to find cutoff values. Results: RBC, WBC (all subtypes including immature granulocytes), platelet indices including PMI, NLR and PLR were all similar. Only RDW and NRBC were found to be significantly increased in GDM patients and came out to be independent predictors of GDM with maternal age and screening week. Conclusion: These findings suggest that women with GDM may be accompanied with increased RDW and NRBC levels which seem to be independent predictors of this disease and these parameters may be used to monitor and evaluate the development of GDM.

Evaluation of platelet parameters in patients with gestational diabetes mellitus (GDM)

“…However, IG% values were statistically significantly different between the GDM and control groups (p=0.002). To the best of our knowledge, the study by Aytan et al [16] was the first to evaluate the IG% value in GDM patients. This marker has been reported to increase before conventional markers in inflammatory conditions [15].…”

“…The percentage of immature granulocytes (IG%) is an inflammatory marker seen in complete blood count. It has been reported that in inflammatory conditions, it rises much earlier than conventional parameters such as CRP [15,16]. Although some studies have found no association between GDM and %IG [17], there are still not enough studies on this topic.…”