Basolateral amygdala inactivation impairs learned (but not innate) fear response in rats

Ribeiro, Alessandra Mussi; Barbosa, Flávio Freitas; Munguba, Hermany; Costa, Miriam S.M.O.; Cavalcante, Jeferson de Souza; Silva, Regina H.

doi:10.1016/j.nlm.2011.02.004

Cited by 26 publications

(18 citation statements)

References 73 publications

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“…However, although less ecologically valid, the operant nature of the RDM task (Simon et al, 2009) may be more amenable to this approach Simon et al, 2011). In contrast, the PORT task could be a useful tool in pursuing the neurobiological underpinnings of risktaking behaviour, where lesion studies have found a role for the amygdala, for example, in regulating risk-taking behaviour under risk of predation (Choi & Kim, 2010) and in response to predator odour-induced fear (Takahashi et al, 2007Martinez et al, 2011Ribeiro et al, 2011).…”

Section: Comparison Of Rodent Risk-taking Tasksmentioning

confidence: 99%

Measuring risk‐taking in mice: balancing the risk between seeking reward and danger

Dent

Isles

Humby

2013

Eur J of Neuroscience

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Assessing risk is an essential part of human behaviour and may be disrupted in a number of psychiatric conditions. Currently, in many animal experimental designs the basis of the potential 'risk' is loss or attenuation of reward, which fail to capture 'real-life' risky situations where there is a trade-off between a separate cost and reward. The development of rodent tasks where two separate and conflicting factors are traded against each other has begun to address this discrepancy. Here, we discuss the merits of these risk-taking tasks and describe the development of a novel test for mice - the 'predator-odour risk-taking' task. This paradigm encapsulates a naturalistic approach to measuring risk-taking behaviour where mice have to balance the benefit of gaining a food reward with the cost of exposure to a predator odour using a range of different odours (rat, cat and fox). We show that the 'predator-odour risk-taking' task was sensitive to the trade-off between cost and benefit by demonstrating reduced motivation to collect food reward in the presence of these different predator odours in two strains of mice and, also, if the value of the food reward was reduced. The 'predator-odour risk-taking' task therefore provides a strong platform for the investigation of the genetic substrates of risk-taking behaviour using mouse models, and adds a further dimension to other recently developed rodent tests.

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Section: Comparison Of Rodent Risk-taking Tasksmentioning

confidence: 99%

Measuring risk‐taking in mice: balancing the risk between seeking reward and danger

Dent

Isles

Humby

2013

Eur J of Neuroscience

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“…It is important to note that the PM‐DAT model contains spatial components, but it is also a nonspatial task (e.g., the constant location of the light provides a prominent nonspatial visual cue), and therefore, it may also be caudate influenced. In addition, Ribeiro and colleagues () recently demonstrated an important participation of the amygdala, for example. In this way, when amygdala was inactivated, it specifically modulated the learning of the aversive task without altering the innate fear response.…”

Section: Discussionmentioning

confidence: 98%

Ethanol‐Induced Memory Impairment in a Discriminative Avoidance Task is State‐Dependent

Sanday

Patti

Zanin

et al. 2012

Alcoholism Clin & Exp Res

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“…As corticosterone alone cannot fully explain our cognitive findings, another possibility that could be raised is the influence of glucose levels on memory. In this way, there is a large body of literature showing that administration of exogenous glucose can enhance memory performance, including performance on amygdala-mediated tasks (Canal et al, 2005;Gold, 1995;Korol and Gold, 1998;Krebs-Kraft and Parent, 2008;Lee et al, 1988;Manning et al, 1992;Gold, 1998, 2002;McNay et al, 2006;Pych et al, 2006), which is the case of the PM-DAT (Ribeiro et al, 2011). In this regard, Sandusky et al (2013) suggested that the metabolic demands of mnemonic processing could be similar throughout brain regions.…”

Section: Discussionmentioning

confidence: 99%

Food restriction increases long-term memory persistence in adult or aged mice

Talhati

Patti

Zanin

et al. 2014

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Food restriction (FR) seems to be the unique experimental manipulation that leads to a remarkable increase in lifespan in rodents. Evidences have suggested that FR can enhance memory in distinct animal models mainly during aging. However, only few studies systemically evaluated the effects FR on memory formation in both adult (3-month-old) and aged (18-24-month-old) mice. Thus, the aim of the present study was to investigate the effects of acute (12h) or repeated (12h/day for 2days) FR protocols on learning and memory of adult and aged mice evaluated in the plus-maze discriminative avoidance task (PM-DAT), an animal model that concurrently (but independently) evaluates learning and memory, anxiety and locomotion. We also investigated the possible role of FR-induced stress by the corticosterone concentration in adult mice. Male mice were kept at home cage with food ad libitum (CTRL-control condition) or subjected to FR during the dark phase of the cycle for 12h/day or 12h/2days. The FR protocols were applied before training, immediately after it or before testing. Our results demonstrated that only FR for 2days enhanced memory persistence when applied before training in adults and before testing in aged mice. Conversely, FR for 2days impaired consolidation and exerted no effects on retrieval irrespective of age. These effects do not seem to be related to corticosterone concentration. Collectively, these results indicate that FR for 2days can promote promnestic effects not only in aged mice but also in adults.

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Basolateral amygdala inactivation impairs learned (but not innate) fear response in rats

Cited by 26 publications

References 73 publications

Measuring risk‐taking in mice: balancing the risk between seeking reward and danger

Measuring risk‐taking in mice: balancing the risk between seeking reward and danger

Ethanol‐Induced Memory Impairment in a Discriminative Avoidance Task is State‐Dependent

Food restriction increases long-term memory persistence in adult or aged mice

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