Basophils are recruited and localized at the site of tick bites in humans

Kimura, Ryoko; Sugita, Kazunari; Ito, Ayako; Goto, Hiroyuki; Yamamoto, Osamu

doi:10.1111/cup.13045

Cited by 11 publications

(8 citation statements)

References 9 publications

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“…3). 122 These epithelial cytokines activate basophils, ILC2s, and DCs, and are involved in type 2 inflammation 123,124 . ILC2s directly target TJs and reduce barrier integrity in human keratinocytes (Fig.…”

Section: Tight Junction In Atopic Dermatitismentioning

confidence: 99%

Tight junctions in the development of asthma, chronic rhinosinusitis, atopic dermatitis, eosinophilic esophagitis, and inflammatory bowel diseases

Sugita

Kabashima

2020

Journal of Leukocyte Biology

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This review focuses on recent developments related to asthma, chronic rhinosinusitis, atopic dermatitis (AD), eosinophilic esophagitis, and inflammatory bowel diseases (IBD), with a particular focus on tight junctions (TJs) and their role in the pathogenetic mechanisms of these diseases. Lung, skin, and intestinal surfaces are lined by epithelial cells that interact with environmental factors and immune cells. Therefore, together with the cellular immune system, the epithelium performs a pivotal role as the first line physical barrier against external antigens. Paracellular space is almost exclusively sealed by TJs and is maintained by complex protein-protein interactions. Thus, TJ dysfunction increases paracellular permeability, resulting in enhanced flux across TJs. Epithelial TJ dysfunction also causes immune cell activation and contributes to the pathogenesis of chronic lung, skin, and intestinal inflammation. Characterization of TJ protein alteration is one of the key factors for enhancing our understanding of allergic diseases as well as IBDs. Furthermore, TJ-based epithelial disturbance can promote immune cell behaviors, such as those in dendritic cells, Th2 cells, Th17 cells, and innate lymphoid cells (ILCs), thereby offering new insights into TJ-based targets. The purpose of this review is to illustrate how TJ dysfunction can lead to the disruption of the immune homeostasis in barrier tissues and subsequent inflammation.This review also highlights the various TJ barrier dysfunctions across different organ sites, which would help to develop future drugs to target allergic diseases and IBD.

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Section: Tight Junction In Atopic Dermatitismentioning

confidence: 99%

Tight junctions in the development of asthma, chronic rhinosinusitis, atopic dermatitis, eosinophilic esophagitis, and inflammatory bowel diseases

Sugita

Kabashima

2020

Journal of Leukocyte Biology

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“…Considering that the accumulation of basophils was also detected in tick re-infestation sites of mast cell-deficient mice that showed ATR to the infestation with D. variabilis ( 49 , 53 ), basophils likely play a crucial role in ATR in mice infested with D. variabilis as well. Basophil infiltration was also observed in humans at the tick-feeding sites and the skin lesions of scabies ( 55 – 57 ). Although the role for basophils in ATR has not been demonstrated in humans, it was reported that a patient lacking basophils and eosinophils suffered from widespread scabies ( 58 ).…”

Section: Basophils Play a Crucial Role In The Effector Phase Of Atrmentioning

confidence: 95%

Immunobiology of Acquired Resistance to Ticks

2020

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Ticks are blood-sucking arthropods of great importance in the medical and veterinary fields worldwide. They are considered second only to mosquitos as vectors of pathogenic microorganisms that can cause serious infectious disorders, such as Lyme borreliosis and tick-borne encephalitis. Hard ( Ixodid ) ticks feed on host animals for several days and inject saliva together with pathogens to hosts during blood feeding. Some animal species can acquire resistance to blood-feeding by ticks after a single or repeated tick infestation, resulting in decreased weights and numbers of engorged ticks or the death of ticks in subsequent infestations. Importantly, this acquired tick resistance (ATR) can reduce the risk of pathogen transmission from pathogen-infected ticks to hosts. This is the basis for the development of tick antigen-targeted vaccines to forestall tick infestation and tick-borne diseases. Accumulation of basophils is detected in the tick re-infested skin lesion of animals showing ATR, and the ablation of basophils abolishes ATR in mice and guinea pigs, illustrating the critical role for basophils in the expression of ATR. In this review article, we provide a comprehensive overview of recent advances in our understanding of the cellular and molecular mechanisms responsible for the development and manifestation of ATR, with a particular focus on the role of basophils.

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“…In addition, a contribution of basophils is also noticed in the dermal infiltration at the site of tick bite. [37][38][39] Recently, it was reported that basophils and basophil-derived histamine play an important role in acquired tick resistance. 40…”

Section: Pathology Of Ti Ck B Ite Smentioning

confidence: 99%

Tick bites in Japan

Natsuaki

2021

The Journal of Dermatology

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Ticks are blood‐sucking ectoparasites belonging to the order Acarina, class Arachnida. In Japan, eight genera and 46 species are known. Tick bite patients frequently present to dermatology clinics. The main causative species of human tick bites are Ixodes persulcatus and Ixodes ovatus in northern to central Japan, and Amblyomma testudinarium and Haemaphysalis longicornis in western Japan. Tick bites often occur from April to September, particularly in May through July, consistent with the active period for ticks. Although erythema usually does not develop at the tick bite site, a small area of erythema may be seen in some cases. Occasionally, an erythema larger than 50 mm in diameter are formed at the bite site, known as tick‐associated rash illness. It is thought that the erythema is a delayed‐type allergic reaction to the substances in tick saliva. Repeated tick bites induce immunoglobulin E production against galactose‐1,3‐α‐galactose, one of the substances in tick saliva, which may trigger an immediate allergic reaction. The most reliable method to remove a tick sucking blood is en bloc resection of the tick and surrounding skin under local anesthesia. Insect repellent spray containing icaridin or DEET are effective to prevent ticks from attaching and tick‐borne infections. It is important to educate not only dermatologists but also the general public regarding tick bites.

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Basophils are recruited and localized at the site of tick bites in humans

Cited by 11 publications

References 9 publications

Tight junctions in the development of asthma, chronic rhinosinusitis, atopic dermatitis, eosinophilic esophagitis, and inflammatory bowel diseases

Tight junctions in the development of asthma, chronic rhinosinusitis, atopic dermatitis, eosinophilic esophagitis, and inflammatory bowel diseases

Immunobiology of Acquired Resistance to Ticks

Tick bites in Japan

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