Basophils in antihelminth immunity

Jianya, Peng; Siracusa, Mark C.

doi:10.1016/j.smim.2021.101529

Cited by 18 publications

(20 citation statements)

References 111 publications

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“…Basophilia has been described as a feature in several rodent parasite models and in humans their abundance is used as a hallmark feature of helminth infections 91 . Basophils from patients infected with Ascaris , Strongyloides , or Schistosoma can secrete histamine in response to parasite antigen 92 . Basophil precursors reside in the bone marrow and respond to IL-3 and TSLP upon helminth infection 91 .…”

Section: Helminth Infection Induced Immune Responses In the Skinmentioning

confidence: 99%

Tissue-specific immunity in helminth infections

Vacca

Gros

2022

Mucosal Immunology

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A characteristic feature of host responses to helminth infections is the development of profound systemic and tissue-localised Type 2 immune responses that play critical roles in immunity, tissue repair and tolerance of the parasite at tissue sites. These same Type 2 responses are also seen in the tissue-associated immune-pathologies seen in asthma, atopic dermatitis and many forms of allergies. The recent identification of new subtypes of immune cells and cytokine pathways that influence both immune and non-immune cells and tissues creates the opportunity for reviewing helminth parasite–host responses in the context of tissue specific immunity. This review focuses on the new discoveries of the cells and cytokines involved in tissue specific immune responses to helminths and how these contribute to host immunity against helminth infection and allow the host to accommodate the presence of parasites when they cannot be eliminated.

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Section: Helminth Infection Induced Immune Responses In the Skinmentioning

confidence: 99%

Tissue-specific immunity in helminth infections

Vacca

Gros

2022

Mucosal Immunology

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“…At baseline, basophils are extremely rare and represent the least prevalent granulocyte in the blood. However, peripheral basophilia is a hallmark of several helminth infections ( 74 , 75 ). While basophil development has traditionally been reported to occur in the bone marrow, recent work also suggests that basophils can develop from mobilized progenitor cells that enter the periphery in the context of helminth-induced inflammation ( 75 – 77 ).…”

Section: The Contributions Of Basophils To Antihelminth Immunitymentioning

confidence: 99%

“…However, peripheral basophilia is a hallmark of several helminth infections ( 74 , 75 ). While basophil development has traditionally been reported to occur in the bone marrow, recent work also suggests that basophils can develop from mobilized progenitor cells that enter the periphery in the context of helminth-induced inflammation ( 75 – 77 ). Similar to MCs, basophils can produce robust amounts of effector molecules including type 2 cytokines (IL-4 and IL-13), histamines, platelet-activating factor, and lipid mediators (prostaglandins and leukotrienes) that allow them to promote worm clearance ( 75 , 78 ).…”

Section: The Contributions Of Basophils To Antihelminth Immunitymentioning

confidence: 99%

“…While basophil development has traditionally been reported to occur in the bone marrow, recent work also suggests that basophils can develop from mobilized progenitor cells that enter the periphery in the context of helminth-induced inflammation ( 75 – 77 ). Similar to MCs, basophils can produce robust amounts of effector molecules including type 2 cytokines (IL-4 and IL-13), histamines, platelet-activating factor, and lipid mediators (prostaglandins and leukotrienes) that allow them to promote worm clearance ( 75 , 78 ). Additionally, their production of growth factors like amphiregulin and macrophage colony-stimulating factor are also thought to promote tissue reparative pathways ( 79 , 80 ).…”

Section: The Contributions Of Basophils To Antihelminth Immunitymentioning

confidence: 99%

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Communication is key: Innate immune cells regulate host protection to helminths

et al. 2022

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Parasitic helminth infections remain a significant global health issue and are responsible for devastating morbidity and economic hardships. During infection, helminths migrate through different host organs, which results in substantial tissue damage and the release of diverse effector molecules by both hematopoietic and non-hematopoietic cells. Thus, host protective responses to helminths must initiate mechanisms that help to promote worm clearance while simultaneously mitigating tissue injury. The specialized immunity that promotes these responses is termed type 2 inflammation and is initiated by the recruitment and activation of hematopoietic stem/progenitor cells, mast cells, basophils, eosinophils, dendritic cells, neutrophils, macrophages, myeloid-derived suppressor cells, and group 2 innate lymphoid cells. Recent work has also revealed the importance of neuron-derived signals in regulating type 2 inflammation and antihelminth immunity. These studies suggest that multiple body systems coordinate to promote optimal outcomes post-infection. In this review, we will describe the innate immune events that direct the scope and intensity of antihelminth immunity. Further, we will highlight the recent progress made in our understanding of the neuro-immune interactions that regulate these pathways and discuss the conceptual advances they promote.

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“…10 The response to chronic filarial infections, while known to involve Th2 cells, is a complex interplay of innate and adaptive immune features. Among the innate granulocyte populations (also known as polymorphonuclear [PMN] cells), basophils are emerging as key immune regulators during helminth infection, 11 while eosinophils are considered the key granulocyte mediating protective anti-helminth immunity. 12,13 In contrast neutrophils, the most abundant cell type in the human blood, are usually acknowledged for their role during bacterial, viral and fungal infections.…”

Section: Introductionmentioning

confidence: 99%