Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition

Inclan-Rico, Juan M.; Ponessa, John J.; Valero-Pacheco, Nuriban; Hernandez, Christina M.; Sy, Chandler B.; Lemenze, Alexander; Beaulieu, Aimee M.; Siracusa, Mark C.

doi:10.1038/s41590-020-0753-y

Cited by 63 publications

(66 citation statements)

References 62 publications

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“…111,112 In innate type 2 responses, mouse basophils can support priming and activation of ILC2s through IL-4 production, leading to the enhancement of innate type 2 responses. 70,91,95,114 In draining lymph nodes, mouse basophil-derived IL-4 can promote Th2 cell differentiation. 100,101 Thus, basophil-derived IL-4 can contribute to both innate and adaptive type 2 inflammation.…”

Section: Comparison To Il-4 Produced By Ilc2s Andmentioning

confidence: 99%

“…ILC2s also influence Th2 cell‐mediated inflammation, suggesting crosstalk between innate and adaptive type 2 inflammation 111,112 . In innate type 2 responses, mouse basophils can support priming and activation of ILC2s through IL‐4 production, leading to the enhancement of innate type 2 responses 70,91,95,114 . In draining lymph nodes, mouse basophil‐derived IL‐4 can promote Th2 cell differentiation 100,101 .…”

Section: Effector Functions Of Basophil‐derived Factorsmentioning

confidence: 99%

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Basophils and their effector molecules in allergic disorders

Miyake

Shibata

Yoshikawa

et al. 2020

Allergy

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Basophils are the least common granulocytes which possess basophilic granules in their cytoplasm. Although they were first documented by Paul Ehrlich more than 140 years ago, their functional significance had long been an enigma, partly because of their rarity and the lack of analytical tools for basophils. In addition, basophils had been erroneously regarded as "blood-circulating mast cells," due to their similarities to tissue-resident mast cells, such as the expression of high-affinity IgE receptor (FcεRI) on their cell surface and the release of histamine upon their activation. Nevertheless, basophils and mast cells differ in a number of aspects. Basophils circulate in the peripheral blood under homeostatic conditions while mast cells typically reside in peripheral tissues and are hardly detected in the peripheral blood. Transcriptomic analyses revealed that basophils display distinct transcriptomic profiles from mast cells in both mice and humans. [1][2][3] Recent development of analytical tools for basophils has enabled us to identify nonredundant functions of basophils in multiple immune reactions, including allergic inflammation, and protective immunity against parasites. [4][5][6][7][8] In addition, the involvement of basophils is also demonstrated in several nonallergic disorders, such as lupus nephritis, 9-11 chronic obstructive pulmonary disease, 12 allograft rejection, 13,14 and carcinogenesis. 15,16 In this review, we summarize recent advances in our understanding of basophil biology, especially focusing on the roles of basophils in the context of allergic inflammation (Boxes 1 and 2). | ONTOG ENY OF BA SOPHIL SAlthough it is widely accepted that basophils differentiate from hematopoietic stem cells (HSCs), 17,18 the pathway of their differentiation

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Section: Comparison To Il-4 Produced By Ilc2s Andmentioning

confidence: 99%

Section: Effector Functions Of Basophil‐derived Factorsmentioning

confidence: 99%

Basophils and their effector molecules in allergic disorders

Miyake

Shibata

Yoshikawa

et al. 2020

Allergy

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“…34 Recent findings suggest a more complex scenario with a proposed immunomodulatory role for basophils in the airways. 51 Lack of altered expression of other MC/ basophil genes between exacerbation phenotypes suggests that MC/basophil presence in the airway lumen may not be an important predictor of exacerbation risk in COPD.…”

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confidence: 99%

Sputum Gene Expression Reveals Dysregulation of Mast Cells and Basophils in Eosinophilic COPD

Winter¹,

Gibson²,

McDonald³

et al. 2021

COPD

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The clinical and inflammatory associations of mast cells (MCs) and basophils in chronic obstructive pulmonary disease (COPD) are poorly understood. We previously developed and validated a qPCR-based MC/basophil gene signature in asthma to measure these cells in sputum samples. Here, we measured this gene signature in a COPD and control population to explore the relationship of sputum MCs/basophils to inflammatory and COPD clinical characteristics. Patients and Methods: MC/basophil signature genes (TPSAB1/TPSB2, CPA3, ENO2, GATA2, KIT, GPR56, HDC, SOCS2) were measured by qPCR in sputum from a COPD (n=96) and a non-respiratory control (n=17) population. Comparative analyses of gene expression between the COPD and the control population, and between eosinophilic COPD and non-eosinophilic COPD were tested. Logistic regression analysis and Spearman correlation were used to determine relationships of sputum MC/basophil genes to inflammatory (sputum eosinophil proportions, blood eosinophils) and clinical (age, body mass index, quality of life, lung function, past year exacerbations) characteristics of COPD. Results: MC/basophil genes were increased in COPD versus control participants (CPA3, KIT, GATA2, HDC) and between eosinophilic-COPD and non-eosinophilic COPD (TPSB2, CPA3, HDC, SOCS2). We found all MC/basophil genes were positively intercorrelated. In COPD, MC/basophil genes were associated with eosinophilic airway inflammation (GATA2, TPSB2, CPA3, GPR56, HDC, SOCS2), blood eosinophilia (all genes) and decreased lung function (KIT, GATA2, GPR56, HDC). Conclusion:We demonstrate associations of MCs and basophils with eosinophilic inflammation and lower lung function in COPD. These findings are consistent with prior results in asthma and may represent a new tool for endotyping eosinophilic-COPD.

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“…In addition, derivatives of testosterone and estradiol have regulatory effects on ILC2s ( 52 , 53 ). Basophils can enhance the expression of the neuropeptide neuromedin B (NMB) receptor in mouse ILC2s, and NMB stimulation can inhibit ILC2-mediated type 2 inflammation ( 54 ). Compared with wild-type Esr1-/- mice, those stimulated by Alternaria extract (Alt Ext) exhibited fewer IL-33eGFP+ epithelial cells, reduced IL-33 release, reduced secretion of IL-5 and IL-13 and fewer bronchoalveolar lavage (BAL) eosinophils.…”

Section: Initiation Of the Ilc2 Response During Allergic Reactionsmentioning

confidence: 99%

The Role of Type 2 Innate Lymphoid Cells in Allergic Diseases

et al. 2021

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Allergic diseases are significant diseases that affect many patients worldwide. In the past few decades, the incidence of allergic diseases has increased significantly due to environmental changes and social development, which has posed a substantial public health burden and even led to premature death. The understanding of the mechanism underlying allergic diseases has been substantially advanced, and the occurrence of allergic diseases and changes in the immune system state are known to be correlated. With the identification and in-depth understanding of innate lymphoid cells, researchers have gradually revealed that type 2 innate lymphoid cells (ILC2s) play important roles in many allergic diseases. However, our current studies of ILC2s are limited, and their status in allergic diseases remains unclear. This article provides an overview of the common phenotypes and activation pathways of ILC2s in different allergic diseases as well as potential research directions to improve the understanding of their roles in different allergic diseases and ultimately find new treatments for these diseases.

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Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition

Cited by 63 publications

References 62 publications

Basophils and their effector molecules in allergic disorders

Basophils and their effector molecules in allergic disorders

Sputum Gene Expression Reveals Dysregulation of Mast Cells and Basophils in Eosinophilic COPD

The Role of Type 2 Innate Lymphoid Cells in Allergic Diseases

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