Bat Influenza A(HL18NL11) Virus in Fruit Bats, Brazil

Campos, Angélica Cristine de Almeida; Góes, Luiz Gustavo Bentim; Moreira-Soto, Andrés; Carvalho, Catherine Teixeira de; Ambar, Guilherme; Sander, Anna-Lena; Fischer, Carlo; Rosa, Adriana Rückert da; Oliveira, Debora Cardoso de; Kataoka, Ana Paula; Pedro, Wagner André; Martorelli, Luzia Fátima Alves; Queiroz, Luzia Helena; Cruz‐Neto, Ariovaldo P.; Durigon, Edison Luiz; Drexler, Jan Felix

doi:10.3201/eid2502.181246

Cited by 44 publications

(40 citation statements)

References 15 publications

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“…Surveillance studies in two different species of fruit bats, the little yellow-shouldered bat (Sturnira lilium) in Guatemala and the flatfaced fruit-eating bat (Artibeus jamaicensis) in Peru, led to the characterization of type A-like influenza viruses, H17N10 and H18N11, respectively (Tong et al 2012(Tong et al , 2013. More recently, surveillance studies in Egypt revealed the presence of another bat virus, more similar to avian-origin influenza virus strains than those previously characterized in Central and South America (Tong et al 2012;Campos et al 2019;Kandeil et al 2019). The Egyptian fruit bat (Rousettus aegyptiacus) virus isolates contain an HA segment with common ancestry with other H9 viruses, and low-level cross-reactivity with serum raised against H9N2 viruses (Kandeil et al 2019).…”

Section: H9-like Viruses In Fruit Batsmentioning

confidence: 99%

H9 Influenza Viruses: An Emerging Challenge

Carnaccini

Pérez

2019

Cold Spring Harb Perspect Med

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Influenza A viruses (IAVs) of the H9 subtype are enzootic in Asia, the Middle East, and parts of North and Central Africa, where they cause significant economic losses to the poultry industry. Of note, some strains of H9N2 viruses have been linked to zoonotic episodes of mild respiratory diseases. Because of the threat posed by H9N2 viruses to poultry and human health, these viruses are considered of pandemic concern by the World Health Organization (WHO). H9N2 IAVs continue to diversify into multiple antigenically and phylogenetically distinct lineages that can further promote the emergence of strains with pandemic potential. Somewhat neglected compared with the H5 and H7 subtypes, there are numerous indicators that H9N2 viruses could be involved directly or indirectly in the emergence of the next influenza pandemic. The goal of this work is to discuss the state of knowledge on H9N2 IAVs and to provide an update on the contemporary global situation.

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Section: H9-like Viruses In Fruit Batsmentioning

confidence: 99%

H9 Influenza Viruses: An Emerging Challenge

Carnaccini

Pérez

2019

Cold Spring Harb Perspect Med

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“…As a consequence, IAVs are exposed to recurrent selective pressures, leading to a range of virus variants that are able to cope with the new host environment [1]. Bats were not considered to be part of this IAV habitat until recently, when two phylogenetically distinct IAV lineages, designated H17N10 and H18N11, were identified in the New World bats Sturnira lilium and Artibeus spp, respectively [2][3][4]. Likewise, Old World bats can harbor influenza viruses, as exemplified by the genetically distinct H9N2 virus found in Egyptian fruit bats (Rousettus aegyptiacus) [5].…”

Section: Introductionmentioning

confidence: 99%

Bats reveal the true power of influenza A virus adaptability

et al. 2020

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“…Alternatively, the lack of transmission could also be attributed to an Artibeus species specificity of H18N11. Although various South American fruit bat species have been found seropositive for H17 and H18 [9], until now full H18N11 genomic sequences or infectious viruses have been only isolated from Artibeus planirostris and Artibeus lituratus or Artibeus jamaicensis, respectively [9,18,31]. Considering this, it is tempting to speculate that species-specific differences in the immunity or the adaptation of H18 to MHC-II molecules of Artibeus spp.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Experimental Oro-Nasal Inoculation of Seba’s Short-Tailed Bats (Carollia perspicillata) with Bat Influenza A Virus H18N11

Gorka

Schinköthe

Ulrich

et al. 2020

Viruses

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In 2012 and 2013, the genomic sequences of two novel influenza A virus (IAV) subtypes, designated H17N10 and H18N11, were identified via next-generation sequencing in the feces of the little yellow-shouldered fruit bat (Sturnira lilium) and the flat-faced fruit-eating bat (Artibeus planirostris), respectively. The pathogenesis caused by these viruses in their respective host species is currently insufficiently understood, which is primarily due to the inability to obtain and keep these bat species under appropriate environmental and biosafety conditions. Seba’s short-tailed bats (Carollia perspicillata), in contrast, are close relatives and a natural H18N11 reservoir species, with the advantage of established animal husbandry conditions in academic research. To study viral pathogenesis in more detail, we here oro-nasally inoculated Seba’s short-tailed bats with the bat IAV H18N11 subtype. Following inoculation, bats appeared clinically healthy, but the histologic examination of tissues revealed a mild necrotizing rhinitis. Consistently, IAV-matrix protein and H18-RNA positive cells were seen in lesioned respiratory and olfactory nasal epithelia, as well as in intestinal tissues. A RT-qPCR analysis confirmed viral replication in the conchae and intestines as well as the presence of viral RNA in the excreted feces, without horizontal transmission to naïve contact animals. Moreover, all inoculated animals seroconverted with low titers of neutralizing antibodies.

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Bat Influenza A(HL18NL11) Virus in Fruit Bats, Brazil

Cited by 44 publications

References 15 publications

H9 Influenza Viruses: An Emerging Challenge

H9 Influenza Viruses: An Emerging Challenge

Bats reveal the true power of influenza A virus adaptability

Characterization of Experimental Oro-Nasal Inoculation of Seba’s Short-Tailed Bats (Carollia perspicillata) with Bat Influenza A Virus H18N11

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