Bat Reoviruses

Kohl, Claudia; Kurth, Andreas

doi:10.1002/9781118818824.ch8

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…Another advantage of reovirus as a putative agent in virotherapy is that it is believed to be essentially nonpathogenic in humans. However, this does not preclude the possible emergence of novel viral strains of increased pathogenicity, as suggested in the last few years (Kohl and Kurth, 2015;Thimmasandra Narayanappa et al, 2015;Yang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

A single mutation in the mammalian orthoreovirus S1 gene is responsible for increased interferon sensitivity in a virus mutant selected in Vero cells

et al. 2019

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Section: Introductionmentioning

confidence: 99%

A single mutation in the mammalian orthoreovirus S1 gene is responsible for increased interferon sensitivity in a virus mutant selected in Vero cells

et al. 2019

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“…Previous metagenomic studies on bats have revealed several novel viruses from a diverse group of viral families [13,16,18,48,49]. The virus families discovered in this study have been detected in several species of bats by conventional PCR and next generation sequencing, including adenoviruses [16,50,51], bunyaviruses [52,53,54], flaviviruses [55,56,57], herpesviruses [16,49,58,59], paramyxoviruses [60,61,62], papillomaviruses [14,16,63,64], parvoviruses [12,59,65,66], picornaviruses [15,59,67], polyomaviruses [14,68,69,70], poxviruses [16,71,72] and reoviruses [73,74,75,76].…”

Section: Discussionmentioning

confidence: 99%

Diversity and Evolution of Viral Pathogen Community in Cave Nectar Bats (Eonycteris spelaea)

Mendenhall

Wen

Jayakumar

et al. 2019

Viruses

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Bats are unique mammals, exhibit distinctive life history traits and have unique immunological approaches to suppression of viral diseases upon infection. High-throughput next-generation sequencing has been used in characterizing the virome of different bat species. The cave nectar bat, Eonycteris spelaea, has a broad geographical range across Southeast Asia, India and southern China, however, little is known about their involvement in virus transmission. Here we investigate the diversity and abundance of viral communities from a colony of Eonycteris spelaea residing in Singapore. Our results detected 47 and 22 different virus families from bat fecal and urine samples, respectively. Among these, we identify a large number of virus families including Adenoviridae, Flaviviridae, Reoviridae, Papillomaviridae, Paramyxoviridae, Parvoviridae, Picornaviridae, and Polyomaviridae. In most cases, viral sequences from Eonycteris spelaea are genetically related to a group of bat viruses from other bat genera (e.g., Eidolon, Miniopterus, Rhinolophus and Rousettus). The results of this study improve our knowledge of the host range, spread and evolution of several important viral pathogens. More significantly, our findings provide a baseline to study the temporal patterns of virus shedding and how they correlate with bat phenological trends.

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“…Despite recent accumulating evidence of transmission to humans or domestic animals of new pathogenic strains [1,2,3], reovirus is generally believed to be almost not pathogenic in humans. Nevertheless, they have been extensively used as a model system by prominent figures of late 20th century virology as Bernard Fields, William Joklik and Aaron Shatkin to name just a few.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Translation of Viral mRNA in Reovirus-Infected Cells: Progress and Remaining Questions

Lemay

2018

Viruses

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At the end of my doctoral studies, in 1988, I published a review article on the major steps of transcription and translation during the mammalian reovirus multiplication cycle, a topic that still fascinates me 30 years later. It is in the nature of scientific research to generate further questioning as new knowledge emerges. Our understanding of these fascinating viruses thus remains incomplete but it seemed appropriate at this moment to look back and reflect on our progress and most important questions that still puzzle us. It is also essential of being careful about concepts that seem so well established, but could still be better validated using new approaches. I hope that the few reflections presented here will stimulate discussions and maybe attract new investigators into the field of reovirus research. Many other aspects of the viral multiplication cycle would merit our attention. However, I will essentially limit my discussion to these central aspects of the viral cycle that are transcription of viral genes and their phenotypic expression through the host cell translational machinery. The objective here is not to review every aspect but to put more emphasis on important progress and challenges in the field.

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Bat Reoviruses

Cited by 4 publications

References 30 publications

A single mutation in the mammalian orthoreovirus S1 gene is responsible for increased interferon sensitivity in a virus mutant selected in Vero cells

A single mutation in the mammalian orthoreovirus S1 gene is responsible for increased interferon sensitivity in a virus mutant selected in Vero cells

Diversity and Evolution of Viral Pathogen Community in Cave Nectar Bats (Eonycteris spelaea)

Synthesis and Translation of Viral mRNA in Reovirus-Infected Cells: Progress and Remaining Questions

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