Batch and continuous fermentation of succinic acid from wood hydrolysate by Mannheimia succiniciproducens MBEL55E

Kim, Do Yun; Yim, Seong Chun; Lee, Pyung Cheon; Lee, Woo Gi; Lee, Sang Yup; Chang, Ho Nam

doi:10.1016/j.enzmictec.2004.08.018

Cited by 165 publications

(59 citation statements)

References 20 publications

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“…Poly(propylene succinate) (PPSu) is a novel biodegradable aliphatic polyester, produced using monomers from renewable resources (5)(6)(7)(8)(9)(10). PPSu has gained an increasing interest, since it has higher biodegradation rate compared to poly(ethylene succinate) (PESu) and poly(butylene succinate) (PBSu).…”

Section: Introductionmentioning

confidence: 99%

Novel Biodegradable Polyester Poly(Propylene Succinate): Synthesis and Application in the Preparation of Solid Dispersions and Nanoparticles of a Water-Soluble Drug

et al. 2009

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Abstract. Poly(propylene succinate) (PPSu) polymers of average molecular weights from 2,800 to 13,100 g/mol were synthesized and characterized with regard to crystallinity, thermal properties, and cytocompatibility. Higher molecular weight samples exhibited lower degree of crystallinity and melted at lower temperatures. Melting of the polymer appeared to begin at 38°C. PPSu cytocompatibility was investigated based on human umbilical vein endothelial cells viability in the presence of increasing concentrations of polymer, and it was found that PPSu exhibited comparable cytocompatibility with poly (DL-lactide). The feasibility of applying PPSu as a drug carrier was shown for the first time, as solid dispersions and nanoparticles of sodium fluvastatin based in PPSu were prepared. Drug release rates decreased with increasing the molecular weight of PPSu in both solid dispersions and nanoparticles. For dispersions prepared from PPSu of the same molecular weight, drug release rates increased with drug loading. It appears that PPSu applicability as a drug carrier warrants further consideration.

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Section: Introductionmentioning

confidence: 99%

Novel Biodegradable Polyester Poly(Propylene Succinate): Synthesis and Application in the Preparation of Solid Dispersions and Nanoparticles of a Water-Soluble Drug

et al. 2009

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“…Various microbial platforms have been explored for bio-production of SA with the best bench-scale performance achieved by Actinobacillus succinogenes [11][12][13][14], Anaerobiospirillum succiniciproducens [15,16], Mannheimia succiniciproducens [17][18][19], and engineered strains of Escherichia coli [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Continuous succinic acid production from xylose by Actinobacillus succinogenes

Bradfield

Nicol

2015

Bioprocess Biosyst Eng

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) and carbohydrate consumption rates were similar. Also, mass balance closures on xylose were up to 18.2% lower than those on glucose. A modified HPLC method revealed pyruvic acid excretion at appreciable concentrations (1.2 -) which improved the mass balance closure by up to 16.8%. Furthermore, redox balances based on the accounted xylose consumed and the excreted metabolites, indicated an overproduction of reducing power. The oxidative pentose phosphate pathway was shown to be a plausible source of the additional reducing power.

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“…succiniciproducens was first isolated [13][14][15][16][17][18][19]. Apart from normal suspended cell systems ('chemostat'), membrane systems with cell recycle as well as biofilm reactors were used in an attempt to enhance productivity [11][12][13]17].…”

Section: Introductionmentioning

confidence: 99%

Continuous succinic acid fermentation by Actinobacillus succinogenes

Heerden

Nicol

2013

Biochemical Engineering Journal

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Fermentations were performed in an external recycle bioreactor using CO2 and D-glucose at feed concentrations of 20 and 40 g L . Severe biofilm formation prevented kinetic analysis of suspended cell ('chemostat') fermentation, while perlite packing enhanced the volumetric productivity by increasing the amount of immobilised cells.The highest productivity of 6.35 g L h was achieved at a dilution rate of 0.56 h . A constant succinic acid yield of 0.69±0.02 g/(g of glucose consumed) was obtained and found to be independent of the dilution rate, transient state and extent of biofilm buildup -approximately 53% of the carbon that formed phosphoenolpyruvate ended up as succinate. Byproduct analysis indicated that pyruvate oxidation proceeded solely via the formate-lyase pathway. Cell growth and corresponding biofilm formation were rapid at dilution rates higher than 0.35 h when the product concentrations were low (succinic acid<10 g L ), while minimal growth was observed at succinic acid concentrations above this threshold.

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Batch and continuous fermentation of succinic acid from wood hydrolysate by Mannheimia succiniciproducens MBEL55E

Cited by 165 publications

References 20 publications

Novel Biodegradable Polyester Poly(Propylene Succinate): Synthesis and Application in the Preparation of Solid Dispersions and Nanoparticles of a Water-Soluble Drug

Novel Biodegradable Polyester Poly(Propylene Succinate): Synthesis and Application in the Preparation of Solid Dispersions and Nanoparticles of a Water-Soluble Drug

Continuous succinic acid production from xylose by Actinobacillus succinogenes

Continuous succinic acid fermentation by Actinobacillus succinogenes

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