Batf is important for IL-4 expression in T follicular helper cells

Sahoo, Anupama; Alekseev, Andrei; Tanaka, Kentaro; Obertas, Lidiya; Lerman, Beatrisa; Haymaker, Cara; Clise-Dwyer, Karen; McMurray, John S.; Nurieva, Roza

doi:10.1038/ncomms8997

Cited by 110 publications

(133 citation statements)

References 37 publications

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“…T follicular helper cells are a major class of Interleukin-4 producing T cells, required for regulation of type 2 humoral immunity. Interleukin-4 (IL-4) was identified as a B cell-stimulating factor critical for class-switch [52] . Circadian disruption also would result in aberrant changes to miRNAs [53] .…”

Section: Discussionmentioning

confidence: 99%

Histological and Immunohistochemical Study on the Effect of Constant Light Exposure on T Lymphocyte Subsets in the Thymus and Lymph Node of Male Albino Rats

Rifaai

Baky

2017

Egyptian Journal of Histology

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Background: Today there is a widespread exposure to high levels of light at night. . This causes divergence from the natural environment and leads to significant implications on the circadian rhythm. Constant light exposure inhibits melatonin secretion and increases serum concentration of corticosterone. The immune system is very sensitive to stress. Aim of the Work: to study the effect of chronic exposure to constant light (as a model of stress) on the T lymphocytes populations and distribution in the thymus and lymph node. Material and Methods: animals were divided into two groups (10 rats each). The 1st group considered as control group, was kept on a day light-darkness for 12-12 h. The 2nd group was kept under complete artificial light for a period of 4 weeks. Thymus glands and the cervical lymph nodes of rats were removed and processed for haematoxylin and eosin, and immunohistochemical staining for CD3, CD4 and CD8. Results: lymphocytic depletion was noticed in the thymus and lymph nodes of the constant light exposed group. Also the distribution of CD3 and CD4 positive cells were altered in the lymph node of the same group. Conclusion: Constant light stress causes lymphocytic depletion and alters lymphoid cell subsets distribution both in the thymus and lymph nodes.

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Section: Discussionmentioning

confidence: 99%

Histological and Immunohistochemical Study on the Effect of Constant Light Exposure on T Lymphocyte Subsets in the Thymus and Lymph Node of Male Albino Rats

Rifaai

Baky

2017

Egyptian Journal of Histology

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“…Our group has recently identified a novel role of Batf in controlling the IL-4 expression in pro-allergic Tfh cells during asthma pathogenesis. Batf-IRF4 complex in cooperation with STAT3 and STAT6 controls IL-4 expression in Tfh cells though the CNS2 element in the IL-4 locus [90]. Whether IL-4 produced by these Tfh cells contributes to the development and maintenance of Tfh cells is an open question.…”

Section: Differentiation Of T Follicular Helper Cellsmentioning

confidence: 99%

“…Our recent study identifies a novel and crucial role of the transcription factor Batf in controlling IL-4 expression in Tfh cells in vivo [90] (Fig. 2).…”

Section: Cytokine Production By Tfh Cellsmentioning

confidence: 99%

Section: Cytokine Production By Tfh Cellsmentioning

confidence: 99%

“…c-MAF is known to be a target of Batf in Tfh cells, which is required for regulation of IL-21 expression and consequently for Tfh expansion [90]. c-MAF is also known to control IL-4 expression in cooperation with IRF4 and NFAT in Th2 cells [90]. We also observed increased binding of c-MAF to the CNS2 locus in Tfh cells as well as c-MAF-induced transactivation of the CNS2 region indicating that c-Maf aids in IL-4 transcription in Tfh cells [90].…”

Section: Cytokine Production By Tfh Cellsmentioning

confidence: 99%

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Insights into the development and regulation of T follicular helper cells

et al. 2016

Self Cite

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T follicular helper (Tfh) cells are specialized subset of T helper (Th) cells necessary for germinal center reaction, affinity maturation and the differentiation of germinal center B cells to antibody-producing plasma B cells and memory B cells. The differentiation of Tfh cells is a multistage, multifactorial process involving a variety of cytokines, surface molecules and transcription factors. While Tfh cells are critical components of protective immune responses against pathogens, regulation of these cells is crucial to prevent autoimmunity and airway inflammation. Recently, it has been noted that Tfh cells could be potentially implicated either in cancer progression or prevention. Thus, the elucidation of the mechanisms that regulate Tfh cell differentiation, function and fate should highlight potential targets for novel therapeutic approaches. In this review, we summarize the latest advances in our understanding of the regulation of Tfh cell differentiation and their role in health and disease.

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BATF is Required for Treg Homeostasis and Stability to Prevent Autoimmune Pathology

Khatun,

Wu,

et al. 2023

Advanced Science

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Regulatory T (Treg) cells are inevitable to prevent deleterious immune responses to self and commensal microorganisms. Treg function requires continuous expression of the transcription factor (TF) FOXP3 and is divided into two major subsets: resting (rTregs) and activated (aTregs). Continuous T cell receptor (TCR) signaling plays a vital role in the differentiation of aTregs from their resting state, and in their immune homeostasis. The process by which Tregs differentiate, adapt tissue specificity, and maintain stable phenotypic expression at the transcriptional level is still inconclusivei. In this work, the role of BATF is investigated, which is induced in response to TCR stimulation in naïve T cells and during aTreg differentiation. Mice lacking BATF in Tregs developed multiorgan autoimmune pathology. As a transcriptional regulator, BATF is required for Treg differentiation, homeostasis, and stabilization of FOXP3 expression in different lymphoid and non‐lymphoid tissues. Epigenetically, BATF showed direct regulation of Treg‐specific genes involved in differentiation, maturation, and tissue accumulation. Most importantly, FOXP3 expression and Treg stability require continuous BATF expression in Tregs, as it regulates demethylation and accessibility of the CNS2 region of the Foxp3 locus. Considering its role in Treg stability, BATF should be considered an important therapeutic target in autoimmune disease.

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Batf is important for IL-4 expression in T follicular helper cells

Cited by 110 publications

References 37 publications

Histological and Immunohistochemical Study on the Effect of Constant Light Exposure on T Lymphocyte Subsets in the Thymus and Lymph Node of Male Albino Rats

Histological and Immunohistochemical Study on the Effect of Constant Light Exposure on T Lymphocyte Subsets in the Thymus and Lymph Node of Male Albino Rats

Insights into the development and regulation of T follicular helper cells

BATF is Required for Treg Homeostasis and Stability to Prevent Autoimmune Pathology

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