BAX -248 G>A and BCL2 -938 C>A Variant Lowers the Survival in Patients with Nasopharyngeal Carcinoma and Could be Associated with Tissue-Specific Malignancies: A Multi-Method Approach

Abstract

Background:The association of BAX -248 G>A and BCL2 -938 C>A with different cancers created conflicts. We studied the correlation and the effect of these polymorphisms in patients with Nasopharyngeal Carcinoma (NPC). Methods: PCR-RFLP and Sanger sequencing were used to detect polymorphisms. Statistical analysis including forest plot and Kaplan-Meier Log-rank test was conducted to investigate the association and effect of these SNPs on the NPC patients' survival. The computational study was performed to investigate the possible regulatory role between these polymorphisms and the poor survival of NPC patients. Meta-analysis was executed to check the tissue-specific association of these polymorphisms in the context of global cancer prognosis. Results: We observed an increased and significant

Metformin attenuates symptoms of osteoarthritis: role of genetic diversity of Bcl2 and CXCL16 in OA

“…Previous studies suggest that the C allele increases the activity of the P2 promoter and thus inhibits gene transcription by the P1 promoter and promotes apoptosis by reducing Bcl-2 gene expression [26][27][28]. The A allele is reported to be associated with increased cancer risk by increasing the expression level of Bcl-2 and inhibiting apoptosis [28,[84][85][86]. According to different studies, Bcl-2 mRNA expression level is significantly decreased in the cartilage tissue of patients with high degree of OA or in animal models; however, in other studies, this reduction of Bcl-2 level was not supported statistically [22,[87][88][89].…”