Bayesian analysis suggests independent development of sensitization to different fungal allergens

Rodinkova, Victoria; Yuriev, Serhii; Mokin, Vitalii; Kryvopustova, Mariia; Shmundiak, Dmytro; Bortnyk, Mykyta; Kryzhanovskyi, Yevhenii; Kurchenko, Andrii

doi:10.1016/j.waojou.2024.100908

World Allergy Organization Journal

2024

DOI: 10.1016/j.waojou.2024.100908

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Bayesian analysis suggests independent development of sensitization to different fungal allergens

Victoria Rodinkova,

Serhii Yuriev,

Vitalii Mokin

et al.

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2024

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Fungi-sensitized individuals have unique profiles where Alt a 1 dominates promoting response to grass, ragweed and cat allergens

Kalyniuk,

Rodinkova,

Yuriev

et al. 2024

Front. Allergy

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IntroductionThe aim of our work was to determine comprehensively the sensitization profile of patients hypersensitive to fungal allergenic components in the Ukrainian population, identifying features of their co-sensitization to allergens of other groups and establishing potential relationships between causative allergens and their ability to provoke this hypersensitivity.MethodsA set of programs was developed using Python and R programming languages, implementing the K-means++ clustering method. Bayesian networks were constructed based on the created clusters, allowing for the assessment of the probabilistic interplay of allergen molecules in the sensitization process of patients.Results and discussionIt was found that patients sensitive to fungi are polysensitized, with 84.77% of them having unique allergological profiles, comprising from 2 to several dozen allergens from different groups. The immune response to Alt a 1 may act as the primary trigger for sensitization to other allergens and may contribute to a high probability of developing sensitivity to grasses (primarily to Phl p 2), ragweed extract, and the Amb a 1 pectate lyase, as well as to pectate lyase Cry j 1 and cat allergen Fel d 1. Individuals polysensitized to molecular components of fungi were often sensitive to such cross-reactive molecules as lipocalins Fel d 4 and Can f 6, as well. Sensitivity to Ambrosia extract which dominated in the development of sensitization to ragweed pollen indicating the importance of different allergenic components of this plant's pollen. This hypothesis, along with the assumption that Phl p 2 may be the main trigger for sensitivity to grasses in patients with Alternaria allergy, requires further clinical investigation.

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Fungi-sensitized individuals have unique profiles where Alt a 1 dominates promoting response to grass, ragweed and cat allergens

Kalyniuk,

Rodinkova,

Yuriev

et al. 2024

Front. Allergy

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show abstract

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Bayesian analysis suggests independent development of sensitization to different fungal allergens

Cited by 1 publication

References 30 publications

Fungi-sensitized individuals have unique profiles where Alt a 1 dominates promoting response to grass, ragweed and cat allergens

Fungi-sensitized individuals have unique profiles where Alt a 1 dominates promoting response to grass, ragweed and cat allergens

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