Wall shear stress (WSS) is a relevant hemodynamic indicator of the local stress applied on the endothelium surface. More specifically, its spatiotemporal distribution reveals crucial in the evolution of many pathologies such as aneurysm, stenosis, and atherosclerosis. This paper introduces a new solution, called PaLMA, to quantify the WSS from 4D Flow MRI data. It relies on a twostep local parametric model, to accurately describe the vessel wall and the velocity-vector field in the neighborhood of a given point of interest. Extensive validations have been performed on synthetic 4D Flow MRI data, including four datasets generated from patient specific computational fluid dynamics simulations on carotids. The validation tests are focused on the robustness with respect to noise and on the impact of the resolution level in the context of complex flow patterns. The WSS quantification performance reached by PaLMA is significantly higher than the reference one obtained using the smoothing B-spline method proposed by Potters et al. (2015) method, while the computation time is equivalent for both WSS quantification methods.